 DNA Damage
"DNA Damage" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
| Descriptor ID |
D004249
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| MeSH Number(s) |
G05.355.180
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| Concept/Terms |
DNA Damage- DNA Damage
- DNA Damages
- Damage, DNA
- Damages, DNA
- DNA Injury
- DNA Injuries
- Injuries, DNA
- Injury, DNA
Genotoxic Stress- Genotoxic Stress
- Genotoxic Stresses
- Stresses, Genotoxic
- Stress, Genotoxic
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Below are MeSH descriptors whose meaning is more general than "DNA Damage".
Below are MeSH descriptors whose meaning is more specific than "DNA Damage".
This graph shows the total number of publications written about "DNA Damage" by people in this website by year, and whether "DNA Damage" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1986 | 1 | 0 | 1 | | 1988 | 1 | 1 | 2 | | 1989 | 1 | 0 | 1 | | 1990 | 0 | 1 | 1 | | 1993 | 0 | 3 | 3 | | 1994 | 0 | 3 | 3 | | 1995 | 0 | 2 | 2 | | 1996 | 1 | 0 | 1 | | 1997 | 1 | 0 | 1 | | 1998 | 0 | 1 | 1 | | 1999 | 0 | 3 | 3 | | 2000 | 3 | 3 | 6 | | 2001 | 2 | 4 | 6 | | 2002 | 3 | 2 | 5 | | 2003 | 6 | 1 | 7 | | 2004 | 5 | 4 | 9 | | 2005 | 5 | 6 | 11 | | 2006 | 9 | 3 | 12 | | 2007 | 9 | 6 | 15 | | 2008 | 4 | 4 | 8 | | 2009 | 9 | 3 | 12 | | 2010 | 5 | 7 | 12 | | 2011 | 5 | 8 | 13 | | 2012 | 4 | 5 | 9 | | 2013 | 6 | 13 | 19 | | 2014 | 5 | 10 | 15 | | 2015 | 6 | 3 | 9 | | 2016 | 0 | 3 | 3 |
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Below are the most recent publications written about "DNA Damage" by people in Profiles.
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Ray Chaudhuri A, Callen E, Ding X, Gogola E, Duarte AA, Lee JE, Wong N, Lafarga V, Calvo JA, Panzarino NJ, John S, Day A, Crespo AV, Shen B, Starnes LM, de Ruiter JR, Daniel JA, Konstantinopoulos PA, Cortez D, Cantor SB, Fernandez-Capetillo O, Ge K, Jonkers J, Rottenberg S, Sharan SK, Nussenzweig A. Replication fork stability confers chemoresistance in BRCA-deficient cells. Nature. 2016 07 21; 535(7612):382-7.
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Guarini G, Kiyooka T, Ohanyan V, Pung YF, Marzilli M, Chen YR, Chen CL, Kang PT, Hardwick JP, Kolz CL, Yin L, Wilson GL, Shokolenko I, Dobson JG, Fenton R, Chilian WM. Impaired coronary metabolic dilation in the metabolic syndrome is linked to mitochondrial dysfunction and mitochondrial DNA damage. Basic Res Cardiol. 2016 May; 111(3):29.
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Turner SM, Hoyt AK, ElMallah MK, Falk DJ, Byrne BJ, Fuller DD. Neuropathology in respiratory-related motoneurons in young Pompe (Gaa(-/-)) mice. Respir Physiol Neurobiol. 2016 Jun 15; 227:48-55.
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Yu L, Ma H, Ji X, Volkert MR. The Sub1 nuclear protein protects DNA from oxidative damage. Mol Cell Biochem. 2016 Jan; 412(1-2):165-71.
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O'Connor MJ. Targeting the DNA Damage Response in Cancer. Mol Cell. 2015 Nov 19; 60(4):547-60.
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Zhao W, Jiang G, Bi C, Li Y, Liu J, Ye C, He H, Li L, Song D, Shao R. The dual topoisomerase inhibitor A35 preferentially and specially targets topoisomerase 2a by enhancing pre-strand and post-strand cleavage and inhibiting DNA religation. Oncotarget. 2015 Nov 10; 6(35):37871-94.
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Sweasy JB, Lieberman HB, Volkert M, George D. Evelyn Witkin and the coordinated response to DNA damage. DNA Repair (Amst). 2015 Nov; 35:154-5.
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Malonia SK, Dutta P, Santra MK, Green MR. F-box protein FBXO31 directs degradation of MDM2 to facilitate p53-mediated growth arrest following genotoxic stress. Proc Natl Acad Sci U S A. 2015 Jul 14; 112(28):8632-7.
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Pirela SV, Miousse IR, Lu X, Castranova V, Thomas T, Qian Y, Bello D, Kobzik L, Koturbash I, Demokritou P. Effects of Laser Printer-Emitted Engineered Nanoparticles on Cytotoxicity, Chemokine Expression, Reactive Oxygen Species, DNA Methylation, and DNA Damage: A Comprehensive in Vitro Analysis in Human Small Airway Epithelial Cells, Macrophages, and Lymphoblasts. Environ Health Perspect. 2016 Feb; 124(2):210-9.
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Ghule PN, Xie RL, Colby JL, Jones SN, Lian JB, Wijnen AJ, Stein JL, Stein GS. p53 checkpoint ablation exacerbates the phenotype of Hinfp dependent histone H4 deficiency. Cell Cycle. 2015 Aug 3; 14(15):2501-8.
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