Amyloid Precursor Protein Secretases

"Amyloid Precursor Protein Secretases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Endopeptidases that are specific for AMYLOID PROTEIN PRECURSOR. Three secretase subtypes referred to as alpha, beta, and gamma have been identified based upon the region of amyloid protein precursor they cleave.

Descriptor ID	D053829
MeSH Number(s)	D08.811.277.656.300.032
Concept/Terms	Amyloid Precursor Protein Secretases Amyloid Precursor Protein Secretases Secretases Secretase Amyloid Precursor Protein Secretase APP Secretase Secretase, APP beta-Secretase beta-Secretase beta Secretase gamma-Secretase gamma-Secretase gamma Secretase alpha-Secretase alpha-Secretase alpha Secretase

Below are MeSH descriptors whose meaning is more general than "Amyloid Precursor Protein Secretases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Peptide Hydrolases [D08.811.277.656]
Endopeptidases [D08.811.277.656.300]
Amyloid Precursor Protein Secretases [D08.811.277.656.300.032]

Below are MeSH descriptors whose meaning is related to "Amyloid Precursor Protein Secretases".

Below are MeSH descriptors whose meaning is more specific than "Amyloid Precursor Protein Secretases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Amyloid Precursor Protein Secretases" by people in this website by year, and whether "Amyloid Precursor Protein Secretases" was a major or minor topic of these publications.

Bar chart showing 55 publications over 22 distinct years, with a maximum of 5 publications in 2012 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2001	0	1	1
2003	0	2	2
2005	0	3	3
2006	0	4	4
2007	1	1	2
2008	2	2	4
2009	3	1	4
2010	1	0	1
2011	0	2	2
2012	3	2	5
2013	2	1	3
2014	1	1	2
2015	3	1	4
2016	0	1	1
2017	4	1	5
2018	1	1	2
2019	1	2	3
2020	2	0	2
2023	0	1	1
2024	1	0	1
2025	1	1	2

Below are the most recent publications written about "Amyloid Precursor Protein Secretases" by people in Profiles.

Davis SM, Hildebrand S, MacMillan HJ, Monopoli KR, Buchwald J, Sousa J, Cooper D, Ly S, Echeverria D, McHugh N, Ferguson C, Coles A, Hariharan VN, O'Reilly D, Tang Q, Furgal R, Yamada K, Alterman JF, Gilbert JW, Knox E, Pineda Y, Weston CN, Baer CE, Pai AA, Khvorova A. Systematic analysis of siRNA and mRNA features impacting fully chemically modified siRNA efficacy. Nucleic Acids Res. 2025 Jun 20; 53(12).

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Olety B, Usami Y, Peters P, Wu Y, G?ttlinger H. The ectodomain sheddase ADAM10 restricts HIV-1 propagation and is counteracted by Nef. Sci Adv. 2025 Apr 18; 11(16):eadt1836.

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Wang X, Freiesleben SD, Schneider LS, Preis L, Priller J, Spruth EJ, Altenstein S, Schneider A, Fliessbach K, Wiltfang J, Hansen N, Jessen F, Rostamzadeh A, Duzel E, Glanz W, Incesoy EI, Buerger K, Janowitz D, Ewers M, Perneczky R, Rauchmann BS, Teipel SJ, Kilimann I, Goerss D, Laske C, Munk MHJ, Spottke A, Roy-Kluth N, Heneka MT, Brosseron F, Wagner M, Wolfsgruber S, Ramirez A, Kleineidam L, Stark M, Peters O. Association of Neurogranin and BACE1 With Clinical Cognitive Decline in Individuals With Subjective Cognitive Decline. Neurology. 2024 Oct 22; 103(8):e209806.

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Hossain F, Ucar DA, Monticone G, Ran Y, Majumder S, Larter K, Luu H, Wyczechowska D, Heidari S, Xu K, Shanthalingam S, Matossian M, Xi Y, Burow M, Collins-Burow B, Del Valle L, Hicks C, Zabaleta J, Golde T, Osborne B, Miele L. Sulindac sulfide as a non-immune suppressive ?-secretase modulator to target triple-negative breast cancer. Front Immunol. 2023; 14:1244159.

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Dehury B, Somavarapu AK, Kepp KP. A computer-simulated mechanism of familial Alzheimer's disease: Mutations enhance thermal dynamics and favor looser substrate-binding to ?-secretase. J Struct Biol. 2020 12 01; 212(3):107648.

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Lessard CB, Rodriguez E, Ladd TB, Minter LM, Osborne BA, Miele L, Golde TE, Ran Y. ?-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse ?-secretase modulators do not. Alzheimers Res Ther. 2020 05 19; 12(1):61.

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Esteve P, Rueda-Carrasco J, In?s Mateo M, Martin-Bermejo MJ, Draffin J, Pereyra G, Sandon?s ?, Crespo I, Moreno I, Aso E, Garcia-Esparcia P, Gomez-Tortosa E, R?bano A, Fortea J, Alcolea D, Lleo A, Heneka MT, Valpuesta JM, Esteban JA, Ferrer I, Dom?nguez M, Bovolenta P. Elevated levels of Secreted-Frizzled-Related-Protein 1 contribute to Alzheimer's disease pathogenesis. Nat Neurosci. 2019 08; 22(8):1258-1268.

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Gunner G, Cheadle L, Johnson KM, Ayata P, Badimon A, Mondo E, Nagy MA, Liu L, Bemiller SM, Kim KW, Lira SA, Lamb BT, Tapper AR, Ransohoff RM, Greenberg ME, Schaefer A, Schafer DP. Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling. Nat Neurosci. 2019 07; 22(7):1075-1088.

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Lessard CB, Rodriguez E, Ladd TB, Minter LM, Osborne BA, Miele L, Golde TE, Ran Y. Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells. J Biol Chem. 2019 07 19; 294(29):11276-11285.

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Chen L, Yu P, Zhang L, Zou Y, Zhang Y, Jiang L, Gao R, Xiao H, Qian Y, Wang J. Methamphetamine exposure induces neuropathic protein ?-Amyloid expression. Toxicol In Vitro. 2019 Feb; 54:304-309.

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