B-Cell Activating Factor

"B-Cell Activating Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A tumor necrosis factor superfamily member that plays a role in the regulation of B-LYMPHOCYTE survival. It occurs as a membrane-bound protein that is cleaved to release an biologically active soluble form with specificity to TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN; B-CELL ACTIVATION FACTOR RECEPTOR; and B-CELL MATURATION ANTIGEN.

Descriptor ID	D053264
MeSH Number(s)	D12.644.276.374.750.061 D12.776.395.191 D12.776.467.374.750.061 D12.776.543.550.193 D23.529.374.750.061
Concept/Terms	B-Cell Activating Factor B-Cell Activating Factor Activating Factor, B-Cell B-Lymphocyte Activating Factor Activating Factor, B-Lymphocyte B Lymphocyte Activating Factor THANK Protein BAFF Ligand BLyS Protein B Cell Activating Factor B Lymphocyte Stimulator CD257 Antigen Antigen, CD257 Antigens, CD257 TNF and APOL-Related Leukocyte Expressed Ligand 1 TNF and APOL Related Leukocyte Expressed Ligand 1 TNF Superfamily, Member 13b Tumor Necrosis Factor Ligand Superfamily Member 13b CD257 Antigens TNFSF13B Protein TALL-1 Protein TALL 1 Protein

Below are MeSH descriptors whose meaning is more general than "B-Cell Activating Factor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Tumor Necrosis Factors [D12.644.276.374.750]
B-Cell Activating Factor [D12.644.276.374.750.061]
Proteins [D12.776]
Glycoproteins [D12.776.395]
B-Cell Activating Factor [D12.776.395.191]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Tumor Necrosis Factors [D12.776.467.374.750]
B-Cell Activating Factor [D12.776.467.374.750.061]
Membrane Proteins [D12.776.543]
Membrane Glycoproteins [D12.776.543.550]
B-Cell Activating Factor [D12.776.543.550.193]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Tumor Necrosis Factors [D23.529.374.750]
B-Cell Activating Factor [D23.529.374.750.061]

Below are MeSH descriptors whose meaning is related to "B-Cell Activating Factor".

Below are MeSH descriptors whose meaning is more specific than "B-Cell Activating Factor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "B-Cell Activating Factor" by people in this website by year, and whether "B-Cell Activating Factor" was a major or minor topic of these publications.

Bar chart showing 8 publications over 6 distinct years, with a maximum of 2 publications in 2007 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	0	1	1
2006	1	0	1
2007	1	1	2
2012	1	0	1
2017	1	1	2
2020	1	0	1

Below are the most recent publications written about "B-Cell Activating Factor" by people in Profiles.

Liu J, Clayton K, Gao W, Li Y, Zealey C, Budylowski P, Schwartz J, Yue FY, Bie Y, Rini J, Ostrowski M. Trimeric HIV-1 gp140 fused with APRIL, BAFF, and CD40L on the mucosal gp140-specific antibody responses in mice. Vaccine. 2020 02 24; 38(9):2149-2159.

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Wang Q, Racine JJ, Ratiu JJ, Wang S, Ettinger R, Wasserfall C, Atkinson MA, Serreze DV. Transient BAFF Blockade Inhibits Type 1 Diabetes Development in Nonobese Diabetic Mice by Enriching Immunoregulatory B Lymphocytes Sensitive to Deletion by Anti-CD20 Cotherapy. J Immunol. 2017 12 01; 199(11):3757-3770.

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Sindhava VJ, Oropallo MA, Moody K, Naradikian M, Higdon LE, Zhou L, Myles A, Green N, Nündel K, Stohl W, Schmidt AM, Cao W, Dorta-Estremera S, Kambayashi T, Marshak-Rothstein A, Cancro MP. A TLR9-dependent checkpoint governs B cell responses to DNA-containing antigens. J Clin Invest. 2017 May 01; 127(5):1651-1663.

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Polverino F, Cosio BG, Pons J, Laucho-Contreras M, Tejera P, Iglesias A, Rios A, Jahn A, Sauleda J, Divo M, Pinto-Plata V, Sholl L, Rosas IO, Agustí A, Celli BR, Owen CA. B Cell-Activating Factor. An Orchestrator of Lymphoid Follicles in Severe Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2015 Sep 15; 192(6):695-705.

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Price JV, Haddon DJ, Kemmer D, Delepine G, Mandelbaum G, Jarrell JA, Gupta R, Balboni I, Chakravarty EF, Sokolove J, Shum AK, Anderson MS, Cheng MH, Robinson WH, Browne SK, Holland SM, Baechler EC, Utz PJ. Protein microarray analysis reveals BAFF-binding autoantibodies in systemic lupus erythematosus. J Clin Invest. 2013 Dec; 123(12):5135-45.

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Kiefer K, Oropallo MA, Cancro MP, Marshak-Rothstein A. Role of type I interferons in the activation of autoreactive B cells. Immunol Cell Biol. 2012 May; 90(5):498-504.

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Woodland RT, Fox CJ, Schmidt MR, Hammerman PS, Opferman JT, Korsmeyer SJ, Hilbert DM, Thompson CB. Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival. Blood. 2008 Jan 15; 111(2):750-60.

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Kaur K, Chowdhury S, Greenspan NS, Schreiber JR. Decreased expression of tumor necrosis factor family receptors involved in humoral immune responses in preterm neonates. Blood. 2007 Oct 15; 110(8):2948-54.

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Kaminski DA, Stavnezer J. Stimuli that enhance IgA class switching increase histone 3 acetylation at S alpha, but poorly stimulate sequential switching from IgG2b. Eur J Immunol. 2007 Jan; 37(1):240-51.

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Woodland RT, Schmidt MR, Thompson CB. BLyS and B cell homeostasis. Semin Immunol. 2006 Oct; 18(5):318-26.

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