Interleukin-12 Subunit p40

"Interleukin-12 Subunit p40" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cytokine subunit that is a component of both interleukin-12 and interleukin-23. It binds to the INTERLEUKIN-12 SUBUNIT P35 via a disulfide bond to form interleukin-12 and to INTERLEUKIN-23 SUBUNIT P19 to form interleukin-23.

Descriptor ID	D053762
MeSH Number(s)	D12.644.276.374.465.512.500 D12.644.276.374.465.759.249 D12.776.467.374.465.512.500 D12.776.467.374.465.759.249 D23.529.374.465.512.500 D23.529.374.465.550.249
Concept/Terms	Interleukin-12 Subunit p40 Interleukin-12 Subunit p40 Interleukin 12 Subunit p40 Interleukin-23 Subunit p40 Interleukin 23 Subunit p40 p40, Interleukin-23 Subunit Interleukin-12,23 p40 Subunit Interleukin 12,23 p40 Subunit p40 Subunit, Interleukin-12,23 Interleukin-12b Interleukin 12b IL-12p40 Interleukin-12 beta Chain Chain, Interleukin-12 beta Interleukin 12 beta Chain beta Chain, Interleukin-12

Below are MeSH descriptors whose meaning is more general than "Interleukin-12 Subunit p40".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Interleukins [D12.644.276.374.465]
Interleukin-12 [D12.644.276.374.465.512]
Interleukin-12 Subunit p40 [D12.644.276.374.465.512.500]
Interleukin-23 [D12.644.276.374.465.759]
Interleukin-12 Subunit p40 [D12.644.276.374.465.759.249]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Interleukins [D12.776.467.374.465]
Interleukin-12 [D12.776.467.374.465.512]
Interleukin-12 Subunit p40 [D12.776.467.374.465.512.500]
Interleukin-23 [D12.776.467.374.465.759]
Interleukin-12 Subunit p40 [D12.776.467.374.465.759.249]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Interleukins [D23.529.374.465]
Interleukin-12 [D23.529.374.465.512]
Interleukin-12 Subunit p40 [D23.529.374.465.512.500]
Interleukin-23 [D23.529.374.465.550]
Interleukin-12 Subunit p40 [D23.529.374.465.550.249]

Below are MeSH descriptors whose meaning is related to "Interleukin-12 Subunit p40".

Below are MeSH descriptors whose meaning is more specific than "Interleukin-12 Subunit p40".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Interleukin-12 Subunit p40" by people in this website by year, and whether "Interleukin-12 Subunit p40" was a major or minor topic of these publications.

Bar chart showing 10 publications over 8 distinct years, with a maximum of 2 publications in 2007 and 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	1	1
2006	0	1	1
2007	0	2	2
2008	1	0	1
2011	0	1	1
2015	0	2	2
2018	1	0	1
2021	1	0	1

Below are the most recent publications written about "Interleukin-12 Subunit p40" by people in Profiles.

Muglia Amancio A, Mittereder L, Carletti A, Tosh KW, Green D, Antonelli LR, Gazzinelli RT, Sher A, Jankovic D. IFNs Reset the Differential Capacity of Human Monocyte Subsets to Produce IL-12 in Response to Microbial Stimulation. J Immunol. 2021 04 01; 206(7):1642-1652.

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Chen Y, Sharma S, Assis PA, Jiang Z, Elling R, Olive AJ, Hang S, Bernier J, Huh JR, Sassetti CM, Knipe DM, Gazzinelli RT, Fitzgerald KA. CNBP controls IL-12 gene transcription and Th1 immunity. J Exp Med. 2018 12 03; 215(12):3136-3150.

View in: PubMed
Wongchana W, Lawlor RG, Osborne BA, Palaga T. Impact of Notch1 Deletion in Macrophages on Proinflammatory Cytokine Production and the Outcome of Experimental Autoimmune Encephalomyelitis. J Immunol. 2015 Dec 01; 195(11):5337-46.

View in: PubMed
Ellis CN, LaRocque RC, Uddin T, Krastins B, Mayo-Smith LM, Sarracino D, Karlsson EK, Rahman A, Shirin T, Bhuiyan TR, Chowdhury F, Khan AI, Ryan ET, Calderwood SB, Qadri F, Harris JB. Comparative proteomic analysis reveals activation of mucosal innate immune signaling pathways during cholera. Infect Immun. 2015 Mar; 83(3):1089-103.

View in: PubMed
Caetano BC, Carmo BB, Melo MB, Cerny A, dos Santos SL, Bartholomeu DC, Golenbock DT, Gazzinelli RT. Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi. J Immunol. 2011 Aug 15; 187(4):1903-11.

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Robinson RT, Khader SA, Locksley RM, Lien E, Smiley ST, Cooper AM. Yersinia pestis evades TLR4-dependent induction of IL-12(p40)2 by dendritic cells and subsequent cell migration. J Immunol. 2008 Oct 15; 181(8):5560-7.

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Bogunovic M, Dav? SH, Tilstra JS, Chang DT, Harpaz N, Xiong H, Mayer LF, Plevy SE. Enteroendocrine cells express functional Toll-like receptors. Am J Physiol Gastrointest Liver Physiol. 2007 Jun; 292(6):G1770-83.

View in: PubMed
Zipris D, Lien E, Nair A, Xie JX, Greiner DL, Mordes JP, Rossini AA. TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat. J Immunol. 2007 Jan 15; 178(2):693-701.

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Tomczak MF, Erdman SE, Davidson A, Wang YY, Nambiar PR, Rogers AB, Rickman B, Luchetti D, Fox JG, Horwitz BH. Inhibition of Helicobacter hepaticus-induced colitis by IL-10 requires the p50/p105 subunit of NF-kappa B. J Immunol. 2006 Nov 15; 177(10):7332-9.

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Khader SA, Partida-Sanchez S, Bell G, Jelley-Gibbs DM, Swain S, Pearl JE, Ghilardi N, Desauvage FJ, Lund FE, Cooper AM. Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection. J Exp Med. 2006 Jul 10; 203(7):1805-15.

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