Locus Coeruleus

"Locus Coeruleus" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Bluish-colored region in the superior angle of the FOURTH VENTRICLE floor, corresponding to melanin-like pigmented nerve cells which lie lateral to the PERIAQUEDUCTAL GRAY.

Descriptor ID	D008125
MeSH Number(s)	A08.186.211.132.659.473 A08.186.211.132.810.428.600.650.437
Concept/Terms	Locus Coeruleus Locus Coeruleus Nucleus Pigmentosus Pontis Pontis, Nucleus Pigmentosus Locus Ceruleus Complex Ceruleus Complex, Locus Ceruleus Complices, Locus Complex, Locus Ceruleus Complices, Locus Ceruleus Locus Ceruleus Complices Locus Coeruleus Complex Coeruleus Complex, Locus Coeruleus Complices, Locus Complex, Locus Coeruleus Complices, Locus Coeruleus Locus Coeruleus Complices Locus Caeruleus Locus Ceruleus

Below are MeSH descriptors whose meaning is more general than "Locus Coeruleus".

Anatomy [A]
Nervous System [A08]
Central Nervous System [A08.186]
Brain [A08.186.211]
Brain Stem [A08.186.211.132]
Mesencephalon [A08.186.211.132.659]
Locus Coeruleus [A08.186.211.132.659.473]
Rhombencephalon [A08.186.211.132.810]
Metencephalon [A08.186.211.132.810.428]
Pons [A08.186.211.132.810.428.600]
Pontine Tegmentum [A08.186.211.132.810.428.600.650]
Locus Coeruleus [A08.186.211.132.810.428.600.650.437]

Below are MeSH descriptors whose meaning is related to "Locus Coeruleus".

Below are MeSH descriptors whose meaning is more specific than "Locus Coeruleus".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Locus Coeruleus" by people in this website by year, and whether "Locus Coeruleus" was a major or minor topic of these publications.

Bar chart showing 22 publications over 16 distinct years, with a maximum of 3 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2003	0	2	2
2006	1	1	2
2009	1	0	1
2010	3	0	3
2012	1	0	1
2013	0	1	1
2014	0	1	1
2015	0	1	1
2017	1	0	1
2018	0	1	1
2021	1	0	1
2022	1	1	2
2024	1	1	2
2025	1	0	1
2026	1	0	1

Below are the most recent publications written about "Locus Coeruleus" by people in Profiles.

Koops EA, Giudicessi A, Baena A, Martinez L, Bonillas-Felix N, Medrano R, Dutta J, Gonzalez I, Alvarez S, Aguillon D, Quiroz YT, Jacobs HIL. Vulnerability of the locus coeruleus-entorhinal cortex white matter tract in autosomal dominant Alzheimer's disease. Alzheimers Dement. 2026 Jun; 22(6):e71587.

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Galgani A, Mary A, Lombardo F, Martini N, Scotto M, Tognoni G, Siciliano G, Ceravolo R, Giorgi FS, Heneka MT. Locus coeruleus integrity correlates with plasma soluble Axl levels in Alzheimer's disease patients. Alzheimers Dement. 2025 07; 21(7):e70434.

View in: PubMed
Koops EA, Dutta J, Hanseeuw BJ, Becker JA, Van Egroo M, Prokopiou PC, Price JC, Arnold SE, Sperling RA, Johnson KA, Jacobs HIL. Elevated locus coeruleus metabolism provides resilience against cognitive decline in preclinical Alzheimer's disease. Alzheimers Dement. 2025 01; 21(1):e14385.

View in: PubMed
Bell TR, Franz CE, Eyler LT, Fennema-Notestine C, Puckett OK, Dorros SM, Panizzon MS, Pearce RC, Hagler DJ, Lyons MJ, Beck A, Elman JA, Kremen WS. Probable chronic pain, brain structure, and Alzheimer's plasma biomarkers in older men. J Pain. 2024 Jun; 25(6):104463.

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Bell TR, Elman JA, Beck A, Fennema-Notestine C, Gustavson DE, Hagler DJ, Jack AJ, Lyons MJ, Puckett OK, Toomey R, Franz CE, Kremen WS. Rostral-middle locus coeruleus integrity and subjective cognitive decline in early old age. J Int Neuropsychol Soc. 2023 10; 29(8):763-774.

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Elman JA, Puckett OK, Hagler DJ, Pearce RC, Fennema-Notestine C, Hatton SN, Lyons MJ, McEvoy LK, Panizzon MS, Reas ET, Dale AM, Franz CE, Kremen WS. Associations between MRI-assessed locus coeruleus integrity and cortical gray matter microstructure. Cereb Cortex. 2022 09 19; 32(19):4191-4203.

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Elman JA, Puckett OK, Beck A, Fennema-Notestine C, Cross LK, Dale AM, Eglit GML, Eyler LT, Gillespie NA, Granholm EL, Gustavson DE, Hagler DJ, Hatton SN, Hauger R, Jak AJ, Logue MW, McEvoy LK, McKenzie RE, Neale MC, Panizzon MS, Reynolds CA, Sanderson-Cimino M, Toomey R, Tu XM, Whitsel N, Williams ME, Xian H, Lyons MJ, Franz CE, Kremen WS. MRI-assessed locus coeruleus integrity is heritable and associated with multiple cognitive domains, mild cognitive impairment, and daytime dysfunction. Alzheimers Dement. 2021 06; 17(6):1017-1025.

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Porter-Stransky KA, Centanni SW, Karne SL, Odil LM, Fekir S, Wong JC, Jerome C, Mitchell HA, Escayg A, Pedersen NP, Winder DG, Mitrano DA, Weinshenker D. Noradrenergic Transmission at Alpha1-Adrenergic Receptors in the Ventral Periaqueductal Gray Modulates Arousal. Biol Psychiatry. 2019 02 01; 85(3):237-247.

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Elman JA, Panizzon MS, Hagler DJ, Eyler LT, Granholm EL, Fennema-Notestine C, Lyons MJ, McEvoy LK, Franz CE, Dale AM, Kremen WS. Task-evoked pupil dilation and BOLD variance as indicators of locus coeruleus dysfunction. Cortex. 2017 12; 97:60-69.

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Ahmadi-Soleimani SM, Azizi H, Gompf HS, Semnanian S. Role of orexin type-1 receptors in paragiganto-coerulear modulation of opioid withdrawal and tolerance: A site specific focus. Neuropharmacology. 2017 Nov; 126:25-37.

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