STAT1 Transcription Factor

"STAT1 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A signal transducer and activator of transcription that mediates cellular responses to INTERFERONS. Stat1 interacts with P53 TUMOR SUPPRESSOR PROTEIN and regulates expression of GENES involved in growth control and APOPTOSIS.

Descriptor ID	D050794
MeSH Number(s)	D12.644.360.024.303.500.500 D12.644.360.024.342.100 D12.776.157.057.061.500.500 D12.776.157.057.186.100 D12.776.260.513.249.500 D12.776.476.024.386.500.500 D12.776.476.024.430.100 D12.776.930.354.249.500 D12.776.930.840.100
Concept/Terms	STAT1 Transcription Factor STAT1 Transcription Factor Transcription Factor, STAT1 Transcription Factor STAT91 Gamma-Activated Factor, 91 kDa Gamma Activated Factor, 91 kDa STAT-91 Transcription Factor STAT 91 Transcription Factor Transcription Factor, STAT-91 STAT-91 Protein STAT 91 Protein STAT91 Transcription Factor Transcription Factor, STAT91 STAT1 Protein Signal Transducer and Activator of Transcription 1

Below are MeSH descriptors whose meaning is more general than "STAT1 Transcription Factor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
Interferon-Stimulated Gene Factor 3 [D12.644.360.024.303]
Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.644.360.024.303.500]
STAT1 Transcription Factor [D12.644.360.024.303.500.500]
STAT Transcription Factors [D12.644.360.024.342]
STAT1 Transcription Factor [D12.644.360.024.342.100]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
Interferon-Stimulated Gene Factor 3 [D12.776.157.057.061]
Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.776.157.057.061.500]
STAT1 Transcription Factor [D12.776.157.057.061.500.500]
STAT Transcription Factors [D12.776.157.057.186]
STAT1 Transcription Factor [D12.776.157.057.186.100]
DNA-Binding Proteins [D12.776.260]
Interferon-Stimulated Gene Factor 3 [D12.776.260.513]
Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.776.260.513.249]
STAT1 Transcription Factor [D12.776.260.513.249.500]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
Interferon-Stimulated Gene Factor 3 [D12.776.476.024.386]
Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.776.476.024.386.500]
STAT1 Transcription Factor [D12.776.476.024.386.500.500]
STAT Transcription Factors [D12.776.476.024.430]
STAT1 Transcription Factor [D12.776.476.024.430.100]
Transcription Factors [D12.776.930]
Interferon-Stimulated Gene Factor 3 [D12.776.930.354]
Interferon-Stimulated Gene Factor 3, alpha Subunit [D12.776.930.354.249]
STAT1 Transcription Factor [D12.776.930.354.249.500]
STAT Transcription Factors [D12.776.930.840]
STAT1 Transcription Factor [D12.776.930.840.100]

Below are MeSH descriptors whose meaning is related to "STAT1 Transcription Factor".

Below are MeSH descriptors whose meaning is more specific than "STAT1 Transcription Factor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "STAT1 Transcription Factor" by people in this website by year, and whether "STAT1 Transcription Factor" was a major or minor topic of these publications.

Bar chart showing 31 publications over 18 distinct years, with a maximum of 4 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
2003	0	1	1
2004	0	1	1
2005	1	1	2
2006	0	1	1
2007	1	2	3
2008	1	0	1
2009	0	1	1
2010	0	2	2
2012	0	3	3
2013	1	1	2
2014	0	4	4
2016	0	2	2
2019	1	1	2
2020	1	1	2
2021	0	1	1
2022	0	1	1
2023	0	1	1

Below are the most recent publications written about "STAT1 Transcription Factor" by people in Profiles.

Zezulin AU, Yen D, Ye D, Howell ED, Bresciani E, Diemer J, Ren JG, Ahmad MH, Castilla LH, Touw IP, Minn AJ, Tong W, Liu PP, Tan K, Yu W, Speck NA. RUNX1 is required in granulocyte-monocyte progenitors to attenuate inflammatory cytokine production by neutrophils. Genes Dev. 2023 07 01; 37(13-14):605-620.

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Tanagala KKK, Morin-Baxter J, Carvajal R, Cheema M, Dubey S, Nakagawa H, Yoon A, Cheng YL, Taylor A, Nickerson J, Mintz A, Momen-Heravi F. SP140 inhibits STAT1 signaling, induces IFN-? in tumor-associated macrophages, and is a predictive biomarker of immunotherapy response. J Immunother Cancer. 2022 12; 10(12).

View in: PubMed
Break TJ, Oikonomou V, Dutzan N, Desai JV, Swidergall M, Freiwald T, Chauss D, Harrison OJ, Alejo J, Williams DW, Pittaluga S, Lee CR, Bouladoux N, Swamydas M, Hoffman KW, Greenwell-Wild T, Bruno VM, Rosen LB, Lwin W, Renteria A, Pontejo SM, Shannon JP, Myles IA, Olbrich P, Ferr? EMN, Schmitt M, Martin D, Barber DL, Solis NV, Notarangelo LD, Serreze DV, Matsumoto M, Hickman HD, Murphy PM, Anderson MS, Lim JK, Holland SM, Filler SG, Afzali B, Belkaid Y, Moutsopoulos NM, Lionakis MS. Aberrant type 1 immunity drives susceptibility to mucosal fungal infections. Science. 2021 01 15; 371(6526).

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Agarwal S, Vierbuchen T, Ghosh S, Chan J, Jiang Z, Kandasamy RK, Ricci E, Fitzgerald KA. The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans. Nat Commun. 2020 12 11; 11(1):6348.

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Chodisetti SB, Fike AJ, Domeier PP, Schell SL, Mockus TE, Choi NM, Corradetti C, Hou B, Atkins HM, Caricchio R, Decker T, Lukacher AE, Olsen N, Rahman ZSM. Serine Phosphorylation of the STAT1 Transactivation Domain Promotes Autoreactive B Cell and Systemic Autoimmunity Development. J Immunol. 2020 05 15; 204(10):2641-2650.

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Walrath T, Malizia RA, Zhu X, Sharp SP, D'Souza SS, Lopez-Soler R, Parr B, Kartchner B, Lee EC, Stain SC, Iwakura Y, O'Connor W. IFN-? and IL-17A regulate intestinal crypt production of CXCL10 in the healthy and inflamed colon. Am J Physiol Gastrointest Liver Physiol. 2020 03 01; 318(3):G479-G489.

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Park EJ, Sang-Ngern M, Chang LC, Pezzuto JM. Physalactone and 4?-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1. J Nat Prod. 2019 03 22; 82(3):492-499.

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Myklebust JH, Brody J, Kohrt HE, Kolstad A, Czerwinski DK, W?lchli S, Green MR, Tr?en G, Liest?l K, Beiske K, Houot R, Delabie J, Alizadeh AA, Irish JM, Levy R. Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profiling. Blood. 2017 02 09; 129(6):759-770.

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Driver JP, Racine JJ, Ye C, Lamont DJ, Newby BN, Leeth CM, Chapman HD, Brusko TM, Chen YG, Mathews CE, Serreze DV. Interferon-? Limits Diabetogenic CD8+ T-Cell Effector Responses in Type 1 Diabetes. Diabetes. 2017 03; 66(3):710-721.

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Strassner JP, Harris JE. Understanding mechanisms of autoimmunity through translational research in vitiligo. Curr Opin Immunol. 2016 12; 43:81-88.

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