Islets of Langerhans

"Islets of Langerhans" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.

Descriptor ID	D007515
MeSH Number(s)	A03.734.414 A06.407.414
Concept/Terms	Islets of Langerhans Islets of Langerhans Langerhans Islets Pancreatic Islets Islet, Pancreatic Islets, Pancreatic Pancreatic Islet Nesidioblasts Nesidioblast Pancreas, Endocrine Endocrine Pancreas Islands of Langerhans Langerhans Islands Islet Cells Cell, Islet Cells, Islet Islet Cell

Below are MeSH descriptors whose meaning is more general than "Islets of Langerhans".

Anatomy [A]
Digestive System [A03]
Pancreas [A03.734]
Islets of Langerhans [A03.734.414]
Endocrine System [A06]
Endocrine Glands [A06.407]
Islets of Langerhans [A06.407.414]

Below are MeSH descriptors whose meaning is related to "Islets of Langerhans".

Below are MeSH descriptors whose meaning is more specific than "Islets of Langerhans".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Islets of Langerhans" by people in this website by year, and whether "Islets of Langerhans" was a major or minor topic of these publications.

Bar chart showing 158 publications over 30 distinct years, with a maximum of 13 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	3	0	3
1996	2	1	3
1998	0	1	1
1999	0	1	1
2000	2	2	4
2001	2	1	3
2002	8	4	12
2003	6	5	11
2004	3	8	11
2005	7	6	13
2006	5	3	8
2007	3	3	6
2008	7	1	8
2009	5	2	7
2010	1	1	2
2011	2	1	3
2012	3	3	6
2013	1	2	3
2014	3	2	5
2015	4	3	7
2016	5	0	5
2017	1	4	5
2018	3	2	5
2019	3	2	5
2020	0	6	6
2021	2	2	4
2022	2	0	2
2023	4	0	4
2024	2	2	4
2025	0	1	1

Below are the most recent publications written about "Islets of Langerhans" by people in Profiles.

Arowosegbe A, Guo Z, Vanderleeden E, Derr AG, Wang JP. Janus kinase inhibition prevents autoimmune diabetes in LEW.1WR1 rats. J Autoimmun. 2025 Feb; 151:103358.

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Sundstrom J, Vanderleeden E, Barton NJ, Redick SD, Dawes P, Murray LF, Olson MN, Tran K, Chigas SM, Orszulak AR, Church GM, Readhead B, Oh HS, Harlan DM, Knipe DM, Wang JP, Chan Y, Lim ET. Herpes Simplex Virus 1 Infection of Human Brain Organoids and Pancreatic Stem Cell-Islets Drives Organoid-Specific Transcripts Associated with Alzheimer's Disease and Autoimmune Diseases. Cells. 2024 Nov 29; 13(23).

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Coate KC, Dai C, Singh A, Stanley J, Covington BA, Bradley A, Oladipupo F, Gong Y, Wisniewski S, Sellick K, Spears E, Poffenberger G, Schornack AMR, Bustabad A, Rodgers T, Dey N, Shultz LD, Greiner DL, Yan H, Powers AC, Chen W, Dean ED. Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners. Mol Metab. 2024 Dec; 90:102050.

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Amdare NP, Shultz LD, Greiner DL, DiLorenzo TP. Human insulin as both antigen and protector in type 1 diabetes. Eur J Immunol. 2024 Sep; 54(9):e2350949.

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Callebaut A, Guyer P, Derua R, Buitinga M, Manganaro A, Yi X, Sodr? FMC, Vig S, Suleiman M, Marchetti P, Eizirik DL, Kent SC, Mathieu C, James EA, Overbergh L. CD4+ T Cells From Individuals With Type 1 Diabetes Respond to a Novel Class of Deamidated Peptides Formed in Pancreatic Islets. Diabetes. 2024 May 01; 73(5):728-742.

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Walker JT, Saunders DC, Rai V, Chen HH, Orchard P, Dai C, Pettway YD, Hopkirk AL, Reihsmann CV, Tao Y, Fan S, Shrestha S, Varshney A, Petty LE, Wright JJ, Ventresca C, Agarwala S, Aramandla R, Poffenberger G, Jenkins R, Mei S, Hart NJ, Phillips S, Kang H, Greiner DL, Shultz LD, Bottino R, Liu J, Below JE, Parker SCJ, Powers AC, Brissova M. Genetic risk converges on regulatory networks mediating early type 2 diabetes. Nature. 2023 Dec; 624(7992):621-629.

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James EA, Joglekar AV, Linnemann AK, Russ HA, Kent SC. The beta cell-immune cell interface in type 1 diabetes (T1D). Mol Metab. 2023 Dec; 78:101809.

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Ciecko AE, Wang Y, Harleston S, Drewek A, Serreze DV, Geurts AM, Lin CW, Chen YG. Heterogeneity of Islet-Infiltrating IL-21+ CD4 T Cells in a Mouse Model of Type 1 Diabetes. J Immunol. 2023 04 01; 210(7):935-946.

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Derr AG, Arowosegbe A, Satish B, Redick SD, Qaisar N, Guo Z, Vanderleeden E, Trombly MI, Baer CE, Harlan DM, Greiner DL, Garber M, Wang JP. An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes. Diabetes. 2023 Feb 01; 72(2):261-274.

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Kayhan S, Hepsen S, Kalkisim HK, Sendur IN, Altay FA, Yalcindag A. The evaluation of pancreas ?-cell autoantibodies in non-diabetic COVID-19 patients. Arch Endocrinol Metab. 2022 Sept 08; 66(4):459-465.

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