Islets of Langerhans

"Islets of Langerhans" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.

Descriptor ID	D007515
MeSH Number(s)	A03.734.414 A06.407.414
Concept/Terms	Islets of Langerhans Islets of Langerhans Langerhans Islets Pancreatic Islets Islet, Pancreatic Islets, Pancreatic Pancreatic Islet Nesidioblasts Nesidioblast Pancreas, Endocrine Endocrine Pancreas Islands of Langerhans Langerhans Islands Islet Cells Cell, Islet Cells, Islet Islet Cell

Below are MeSH descriptors whose meaning is more general than "Islets of Langerhans".

Anatomy [A]
Digestive System [A03]
Pancreas [A03.734]
Islets of Langerhans [A03.734.414]
Endocrine System [A06]
Endocrine Glands [A06.407]
Islets of Langerhans [A06.407.414]

Below are MeSH descriptors whose meaning is related to "Islets of Langerhans".

Below are MeSH descriptors whose meaning is more specific than "Islets of Langerhans".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Islets of Langerhans" by people in this website by year, and whether "Islets of Langerhans" was a major or minor topic of these publications.

Bar chart showing 143 publications over 29 distinct years, with a maximum of 13 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	2	2	4
1995	3	0	3
1996	2	1	3
1998	0	1	1
1999	0	1	1
2000	1	2	3
2001	2	1	3
2002	3	2	5
2003	6	4	10
2004	3	8	11
2005	7	6	13
2006	5	3	8
2007	3	3	6
2008	7	1	8
2009	4	2	6
2010	1	0	1
2011	2	1	3
2012	3	3	6
2013	1	2	3
2014	3	2	5
2015	4	3	7
2016	5	0	5
2017	1	4	5
2018	3	2	5
2019	3	2	5
2020	0	5	5
2021	2	2	4
2022	2	0	2
2023	2	0	2

Below are the most recent publications written about "Islets of Langerhans" by people in Profiles.

Ciecko AE, Wang Y, Harleston S, Drewek A, Serreze DV, Geurts AM, Lin CW, Chen YG. Heterogeneity of Islet-Infiltrating IL-21+ CD4 T Cells in a Mouse Model of Type 1 Diabetes. J Immunol. 2023 04 01; 210(7):935-946.

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Derr AG, Arowosegbe A, Satish B, Redick SD, Qaisar N, Guo Z, Vanderleeden E, Trombly MI, Baer CE, Harlan DM, Greiner DL, Garber M, Wang JP. An Early Islet Transcriptional Signature Is Associated With Local Inflammation in Autoimmune Diabetes. Diabetes. 2023 Feb 01; 72(2):261-274.

View in: PubMed
Kayhan S, Hepsen S, Kalkisim HK, Sendur IN, Altay FA, Yalcindag A. The evaluation of pancreas ?-cell autoantibodies in non-diabetic COVID-19 patients. Arch Endocrinol Metab. 2022 Sept 08; 66(4):459-465.

View in: PubMed
MacMillan HJ, Kong Y, Calvo-Roitberg E, Alonso LC, Pai AA. High-throughput analysis of ANRIL circRNA isoforms in human pancreatic islets. Sci Rep. 2022 05 11; 12(1):7745.

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Fu A, van Rooyen L, Evans L, Armstrong N, Avizonis D, Kin T, Bird GH, Reddy A, Chouchani ET, Liesa-Roig M, Walensky LD, Shapiro AMJ, Danial NN. Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets. Cell Rep. 2021 11 23; 37(8):110037.

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Yang K, O'Cearbhaill ED, Liu SS, Zhou A, Chitnis GD, Hamilos AE, Xu J, Verma MKS, Giraldo JA, Kudo Y, Lee EA, Lee Y, Pop R, Langer R, Melton DA, Greiner DL, Karp JM. A therapeutic convection-enhanced macroencapsulation device for enhancing ? cell viability and insulin secretion. Proc Natl Acad Sci U S A. 2021 09 14; 118(37).

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Rodriguez-Calvo T, Christoffersson G, Bender C, von Herrath MG, Mallone R, Kent SC, James EA. Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes? Front Immunol. 2021; 12:683091.

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Landry LG, Anderson AM, Russ HA, Yu L, Kent SC, Atkinson MA, Mathews CE, Michels AW, Nakayama M. Proinsulin-Reactive CD4 T Cells in the Islets of Type 1 Diabetes Organ Donors. Front Endocrinol (Lausanne). 2021; 12:622647.

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Dai C, Walker JT, Shostak A, Bouchi Y, Poffenberger G, Hart NJ, Jacobson DA, Calcutt MW, Bottino R, Greiner DL, Shultz LD, McGuinness OP, Dean ED, Powers AC. Dapagliflozin Does Not Directly Affect Human a or ? Cells. Endocrinology. 2020 08 01; 161(8).

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Evans EA, Sayers SR, Kodji X, Xia Y, Shaikh M, Rizvi A, Frame J, Brain SD, Philpott MP, Hannen RF, Caton PW. Psoriatic skin inflammation induces a pre-diabetic phenotype via the endocrine actions of skin secretome. Mol Metab. 2020 11; 41:101047.

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