Islets of Langerhans

"Islets of Langerhans" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.

Descriptor ID	D007515
MeSH Number(s)	A03.734.414 A06.407.414
Concept/Terms	Islets of Langerhans Islets of Langerhans Langerhans Islets Pancreatic Islets Islet, Pancreatic Islets, Pancreatic Pancreatic Islet Nesidioblasts Nesidioblast Pancreas, Endocrine Endocrine Pancreas Islands of Langerhans Langerhans Islands Islet Cells Cell, Islet Cells, Islet Islet Cell

Below are MeSH descriptors whose meaning is more general than "Islets of Langerhans".

Anatomy [A]
Digestive System [A03]
Pancreas [A03.734]
Islets of Langerhans [A03.734.414]
Endocrine System [A06]
Endocrine Glands [A06.407]
Islets of Langerhans [A06.407.414]

Below are MeSH descriptors whose meaning is related to "Islets of Langerhans".

Below are MeSH descriptors whose meaning is more specific than "Islets of Langerhans".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Islets of Langerhans" by people in this website by year, and whether "Islets of Langerhans" was a major or minor topic of these publications.

Bar chart showing 145 publications over 28 distinct years, with a maximum of 13 publications in 2002 and 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	2	2	4
1995	3	0	3
1996	2	1	3
1998	0	1	1
1999	0	1	1
2000	2	2	4
2001	2	1	3
2002	8	5	13
2003	6	5	11
2004	3	8	11
2005	7	6	13
2006	5	3	8
2007	3	3	6
2008	6	0	6
2009	4	2	6
2010	1	0	1
2011	2	1	3
2012	3	3	6
2013	1	2	3
2014	3	2	5
2015	3	3	6
2016	5	0	5
2017	1	4	5
2018	3	2	5
2019	3	2	5
2020	0	4	4
2021	2	1	3
2022	1	0	1

Below are the most recent publications written about "Islets of Langerhans" by people in Profiles.

MacMillan HJ, Kong Y, Calvo-Roitberg E, Alonso LC, Pai AA. High-throughput analysis of ANRIL circRNA isoforms in human pancreatic islets. Sci Rep. 2022 05 11; 12(1):7745.

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Yang K, O'Cearbhaill ED, Liu SS, Zhou A, Chitnis GD, Hamilos AE, Xu J, Verma MKS, Giraldo JA, Kudo Y, Lee EA, Lee Y, Pop R, Langer R, Melton DA, Greiner DL, Karp JM. A therapeutic convection-enhanced macroencapsulation device for enhancing ? cell viability and insulin secretion. Proc Natl Acad Sci U S A. 2021 09 14; 118(37).

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Rodriguez-Calvo T, Christoffersson G, Bender C, von Herrath MG, Mallone R, Kent SC, James EA. Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes? Front Immunol. 2021; 12:683091.

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Landry LG, Anderson AM, Russ HA, Yu L, Kent SC, Atkinson MA, Mathews CE, Michels AW, Nakayama M. Proinsulin-Reactive CD4 T Cells in the Islets of Type 1 Diabetes Organ Donors. Front Endocrinol (Lausanne). 2021; 12:622647.

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Dai C, Walker JT, Shostak A, Bouchi Y, Poffenberger G, Hart NJ, Jacobson DA, Calcutt MW, Bottino R, Greiner DL, Shultz LD, McGuinness OP, Dean ED, Powers AC. Dapagliflozin Does Not Directly Affect Human ? or ? Cells. Endocrinology. 2020 08 01; 161(8).

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Wright JJ, Saunders DC, Dai C, Poffenberger G, Cairns B, Serreze DV, Harlan DM, Bottino R, Brissova M, Powers AC. Decreased pancreatic acinar cell number in type 1 diabetes. Diabetologia. 2020 07; 63(7):1418-1423.

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Bose S, Volpatti LR, Thiono D, Yesilyurt V, McGladrigan C, Tang Y, Facklam A, Wang A, Jhunjhunwala S, Veiseh O, Hollister-Lock J, Bhattacharya C, Weir GC, Greiner DL, Langer R, Anderson DG. A retrievable implant for the long-term encapsulation and survival of therapeutic xenogeneic cells. Nat Biomed Eng. 2020 08; 4(8):814-826.

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Dai C, Walker JT, Shostak A, Padgett A, Spears E, Wisniewski S, Poffenberger G, Aramandla R, Dean ED, Prasad N, Levy SE, Greiner DL, Shultz LD, Bottino R, Powers AC. Tacrolimus- and sirolimus-induced human ? cell dysfunction is reversible and preventable. JCI Insight. 2020 01 16; 5(1).

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Redick SD, Leehy L, Rittenhouse AR, Blodgett DM, Derr AG, Kucukural A, Garber MG, Shultz LD, Greiner DL, Wang JP, Harlan DM, Bortell R, Jurczyk A. Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice. FASEB J. 2020 01; 34(1):1901-1911.

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Ciecko AE, Foda B, Barr JY, Ramanathan S, Atkinson MA, Serreze DV, Geurts AM, Lieberman SM, Chen YG. Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjögren Syndrome-like Inflammation. Cell Rep. 2019 12 03; 29(10):3073-3086.e5.

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