NLR Family, Pyrin Domain-Containing 3 Protein

"NLR Family, Pyrin Domain-Containing 3 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An NLR protein that contains an N-terminal PYRIN DOMAIN and ATP-binding site and 9 C-terminal LEUCINE-rich repeats; it is expressed primarily by MACROPHAGES. It is a core component of the INFLAMMASOME and directs its assembly in response to pathogen infection and damage-associated stimuli. Mutations in the NLRP3 gene are associated with FAMILIAL COLD AUTOINFLAMMATORY SYNDROME.

Descriptor ID	D000071199
MeSH Number(s)	D12.644.360.539.250
Concept/Terms	NLR Family, Pyrin Domain-Containing 3 Protein NLR Family, Pyrin Domain-Containing 3 Protein NLR Family, Pyrin Domain Containing 3 Protein Cold Autoinflammatory Syndrome 1 Protein NACHT, LRR and PYD Domains-Containing Protein 3 NACHT, LRR and PYD Domains Containing Protein 3 NLRP3 Protein

Below are MeSH descriptors whose meaning is more general than "NLR Family, Pyrin Domain-Containing 3 Protein".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
NLR Proteins [D12.644.360.539]
NLR Family, Pyrin Domain-Containing 3 Protein [D12.644.360.539.250]

Below are MeSH descriptors whose meaning is related to "NLR Family, Pyrin Domain-Containing 3 Protein".

Below are MeSH descriptors whose meaning is more specific than "NLR Family, Pyrin Domain-Containing 3 Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "NLR Family, Pyrin Domain-Containing 3 Protein" by people in this website by year, and whether "NLR Family, Pyrin Domain-Containing 3 Protein" was a major or minor topic of these publications.

Bar chart showing 148 publications over 16 distinct years, with a maximum of 18 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2008	0	2	2
2009	0	2	2
2010	0	8	8
2011	0	8	8
2012	0	12	12
2013	0	18	18
2014	0	16	16
2015	0	9	9
2016	5	3	8
2017	9	1	10
2018	6	5	11
2019	10	3	13
2020	9	2	11
2021	7	6	13
2022	3	2	5
2023	2	0	2

Below are the most recent publications written about "NLR Family, Pyrin Domain-Containing 3 Protein" by people in Profiles.

Zewinger S, Reiser J, Jankowski V, Alansary D, Hahm E, Triem S, Klug M, Schunk SJ, Schmit D, Kramann R, K?rbel C, Ampofo E, Laschke MW, Selejan SR, Paschen A, Herter T, Gaul S, Silbernagel G, Sester M, Sester U, A?mann G, Bals R, Kostner G, Jahnen-Dechent W, Menger MD, Rohrer L, M?rz W, B?hm M, Jankowski J, Kopf M, Latz E, Niemeyer BA, Fliser D, Laufs U, Speer T. Reply to: Apolipoprotein C3 induces inflammasome activation only in its delipidated form. Nat Immunol. 2023 Mar; 24(3):412-413.

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Zhou JY, Sarkar MK, Okamura K, Harris JE, Gudjonsson JE, Fitzgerald KA. Activation of the NLRP1 inflammasome in human keratinocytes by the dsDNA mimetic poly(dA:dT). Proc Natl Acad Sci U S A. 2023 01 31; 120(5):e2213777120.

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Brinkschulte R, Fu?h?ller DM, Hoss F, Rodr?guez-Alc?zar JF, Lauterbach MA, Kolbe CC, Rauen M, Ince S, Herrmann C, Latz E, Geyer M. ATP-binding and hydrolysis of human NLRP3. Commun Biol. 2022 11 03; 5(1):1176.

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Potere N, Del Buono MG, Caricchio R, Cremer PC, Vecchi? A, Porreca E, Dalla Gasperina D, Dentali F, Abbate A, Bonaventura A. Interleukin-1 and the NLRP3 inflammasome in COVID-19: Pathogenetic and therapeutic implications. EBioMedicine. 2022 Nov; 85:104299.

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Akbal A, Dernst A, Lovotti M, Mangan MSJ, McManus RM, Latz E. How location and cellular signaling combine to activate the NLRP3 inflammasome. Cell Mol Immunol. 2022 11; 19(11):1201-1214.

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Hochheiser IV, Pilsl M, Hagelueken G, Moecking J, Marleaux M, Brinkschulte R, Latz E, Engel C, Geyer M. Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3. Nature. 2022 04; 604(7904):184-189.

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Orecchioni M, Kobiyama K, Winkels H, Ghosheh Y, McArdle S, Mikulski Z, Kiosses WB, Fan Z, Wen L, Jung Y, Roy P, Ali AJ, Miyamoto Y, Mangan M, Makings J, Wang Z, Denn A, Vallejo J, Owens M, Durant CP, Braumann S, Mader N, Li L, Matsunami H, Eckmann L, Latz E, Wang Z, Hazen SL, Ley K. Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production. Science. 2022 Jan 14; 375(6577):214-221.

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Ravichandran KA, Heneka MT. Inflammasome activation in neurodegenerative diseases. Essays Biochem. 2021 12 22; 65(7):885-904.

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de Carvalho Ribeiro M, Szabo G. Role of the Inflammasome in Liver Disease. Annu Rev Pathol. 2022 01 24; 17:345-365.

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Christ A, Latz E. Deciphering How NLRP3 Incites the Stromal Response in Kawasaki Vasculitis. Circ Res. 2021 10 15; 129(9):840-842.

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