A DNA (cytosine-5-)-methyltransferase that contains a central CxxC type zinc finger motif. It binds poly(ADP)-ribose and its expression is regulated by POLY (ADP-RIBOSE) POLYMERASE-1. DNMT1 methylates CpG residues, with a preference for hemimethylated DNA, and associates with DNA replication sites in S PHASE to maintain the methylation pattern in the newly synthesized strand, which is essential for EPIGENETIC PROCESSES. It also associates with CHROMATIN during G2 PHASE and MITOSIS to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development; mutations in the DNMT1 gene are associated with HEREDITARY SENSORY NEUROPATHY TYPE 1 class E.

Descriptor ID	D000076123
MeSH Number(s)	D08.811.913.555.500.350.100.500.500 D12.776.157.687.313 D12.776.660.720.313
Concept/Terms	DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferase 1 DNMT1 Enzyme Enzyme, DNMT1

Below are MeSH descriptors whose meaning is more general than "DNA (Cytosine-5-)-Methyltransferase 1".

Below are MeSH descriptors whose meaning is related to "DNA (Cytosine-5-)-Methyltransferase 1".

Below are MeSH descriptors whose meaning is more specific than "DNA (Cytosine-5-)-Methyltransferase 1".