"Amphiregulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An autocrine growth factor and mitogen for a broad range of target cells including EPITHELIAL CELLS; FIBROBLASTS and immune cells. It occurs as a membrane-bound protein that can be cleaved to release an active secreted form.
| Descriptor ID |
D066258
|
| MeSH Number(s) |
D12.644.276.382.249 D12.776.467.382.249 D12.776.543.029 D23.529.382.249
|
| Concept/Terms |
Amphiregulin- Amphiregulin
- Schwannoma-derived Growth Factor
- Schwannoma derived Growth Factor
|
Below are MeSH descriptors whose meaning is more general than "Amphiregulin".
Below are MeSH descriptors whose meaning is more specific than "Amphiregulin".
This graph shows the total number of publications written about "Amphiregulin" by people in this website by year, and whether "Amphiregulin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Amphiregulin" by people in Profiles.
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Silverstein NJ, Wang Y, Manickas-Hill Z, Carbone C, Dauphin A, Boribong BP, Loiselle M, Davis J, Leonard MM, Kuri-Cervantes L, Meyer NJ, Betts MR, Li JZ, Walker BD, Yu XG, Yonker LM, Luban J. Innate lymphoid cells and COVID-19 severity in SARS-CoV-2 infection. Elife. 2022 03 11; 11.
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Varanasi SK, Rajasagi NK, Jaggi U, Rouse BT. Role of IL-18 induced Amphiregulin expression on virus induced ocular lesions. Mucosal Immunol. 2018 11; 11(6):1705-1715.
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Hosur V, Johnson KR, Burzenski LM, Stearns TM, Maser RS, Shultz LD. Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin. Proc Natl Acad Sci U S A. 2014 May 27; 111(21):E2200-9.
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Kasina S, Scherle PA, Hall CL, Macoska JA. ADAM-mediated amphiregulin shedding and EGFR transactivation. Cell Prolif. 2009 Dec; 42(6):799-812.
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Zaiss DM, Yang L, Shah PR, Kobie JJ, Urban JF, Mosmann TR. Amphiregulin, a TH2 cytokine enhancing resistance to nematodes. Science. 2006 Dec 15; 314(5806):1746.
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Asano K, Nakamura H, Lilly CM, Klagsbrun M, Drazen JM. Interferon gamma induces prostaglandin G/H synthase-2 through an autocrine loop via the epidermal growth factor receptor in human bronchial epithelial cells. J Clin Invest. 1997 Mar 01; 99(5):1057-63.