CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire.
Verhagen J, Genolet R, Britton GJ, Stevenson BJ, Sabatos-Peyton CA, Dyson J, Luescher IF, Wraith DC. CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire. Proc Natl Acad Sci U S A. 2013 Jan 15; 110(3):E221-30.