Nitric Oxide

"Nitric Oxide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.

Descriptor ID	D009569
MeSH Number(s)	D01.339.387 D01.625.550.500 D01.625.700.500 D01.650.550.587.600
Concept/Terms	Nitric Oxide Nitric Oxide Oxide, Nitric Nitrogen Monoxide Monoxide, Nitrogen Nitric Oxide, Endothelium-Derived Endothelium-Derived Nitric Oxide Nitric Oxide, Endothelium Derived Endogenous Nitrate Vasodilator Nitrate Vasodilator, Endogenous Vasodilator, Endogenous Nitrate Mononitrogen Monoxide Monoxide, Mononitrogen

Below are MeSH descriptors whose meaning is more general than "Nitric Oxide".

Chemicals and Drugs [D]
Inorganic Chemicals [D01]
Free Radicals [D01.339]
Nitric Oxide [D01.339.387]
Nitrogen Compounds [D01.625]
Nitrogen Oxides [D01.625.550]
Nitric Oxide [D01.625.550.500]
Reactive Nitrogen Species [D01.625.700]
Nitric Oxide [D01.625.700.500]
Oxygen Compounds [D01.650]
Oxides [D01.650.550]
Nitrogen Oxides [D01.650.550.587]
Nitric Oxide [D01.650.550.587.600]

Below are MeSH descriptors whose meaning is related to "Nitric Oxide".

Below are MeSH descriptors whose meaning is more specific than "Nitric Oxide".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Nitric Oxide" by people in this website by year, and whether "Nitric Oxide" was a major or minor topic of these publications.

Bar chart showing 149 publications over 30 distinct years, with a maximum of 14 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	1	1	2
1996	3	0	3
1997	1	0	1
1998	2	0	2
2000	0	1	1
2001	1	2	3
2002	0	5	5
2003	2	1	3
2004	0	2	2
2005	0	3	3
2006	3	5	8
2007	5	4	9
2008	2	2	4
2009	8	3	11
2010	3	7	10
2011	2	6	8
2012	9	5	14
2013	4	4	8
2014	3	3	6
2015	1	2	3
2016	2	5	7
2017	1	3	4
2018	2	4	6
2019	1	3	4
2020	3	3	6
2021	0	8	8
2022	1	3	4
2023	0	1	1
2024	1	1	2
2025	0	1	1

Below are the most recent publications written about "Nitric Oxide" by people in Profiles.

Sang-Ngern M, Fukuchi A, Kondratyuk TP, Park EJ, Simmons CJ, Wall MM, Lorch SE, Pezzuto JM, Chang LC. Biologically active withanolides from Physalis peruviana. Pharm Biol. 2025 Dec; 63(1):334-343.

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Kumar A, Goel HL, Silva CA, Wang T, Geng Y, Wang M, Goel S, Hu K, Li R, Zhu LJ, Clark JL, Ferreira LM, Brehm MA, FitzGerald TJ, Mercurio AM. Neuropilin-2-expressing breast cancer cells mitigate radiation-induced oxidative stress through nitric oxide signaling. J Clin Invest. 2024 10 01; 134(22).

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Maenetje P, Baik Y, Schramm DB, Vangu MDW, Wallis RS, Mlotshwa M, Tiemessen CT, Li Y, Kornfeld H, Churchyard G, Auld SC, Bisson GP. Circulating Biomarkers, Fraction of Exhaled Nitric Oxide, and Lung Function in Patients With Human Immunodeficiency Virus and Tuberculosis. J Infect Dis. 2024 03 14; 229(3):824-832.

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Liu F, O'Donnell TJ, Park EJ, Kovacs S, Nakamura K, Dave A, Luo Y, Sun R, Wall M, Wongwiwatthananukit S, Silva DK, Williams PG, Pezzuto JM, Chang LC. Anti-inflammatory Quinoline Alkaloids from the Roots of Waltheria indica. J Nat Prod. 2023 02 24; 86(2):276-289.

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Dillon GA, Stanhewicz AE, Serviente C, Flores VA, Stachenfeld N, Alexander LM. Seven days of statin treatment improves nitric-oxide mediated endothelial-dependent cutaneous microvascular function in women with endometriosis. Microvasc Res. 2022 11; 144:104421.

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Bosch NA, Law AC, Vail EA, Gillmeyer KR, Gershengorn HB, Wunsch H, Walkey AJ. Inhaled Nitric Oxide vs?Epoprostenol During Acute Respiratory Failure: An Observational Target Trial Emulation. Chest. 2022 Dec; 162(6):1287-1296.

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Moradi F, Eslami F, Rahimi N, Koohfar A, Shayan M, Maadani M, Ghasemi M, Dehpour AR. Modafinil exerts anticonvulsive effects against lithium-pilocarpine-induced status epilepticus in rats: A role for tumor necrosis factor-a and nitric oxide signaling. Epilepsy Behav. 2022 05; 130:108649.

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L?pez Garc?a de Lomana A, Vilhj?lmsson AI, McGarrity S, Sigur?ard?ttir R, Anuforo ?, Viktorsd?ttir AR, Kotronoulas A, Bergmann A, Franzson L, Halld?rsson H, Henriksen HH, Wade CE, Johansson PI, Rolfsson ?. Metabolic Response in Endothelial Cells to Catecholamine Stimulation Associated with Increased Vascular Permeability. Int J Mol Sci. 2022 Mar 15; 23(6).

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Barreira-Silva P, Melo-Miranda R, Nobrega C, Roque S, Serre-Miranda C, Borges M, Armada G, de S? Cal?ada D, Behar SM, Appelberg R, Correia-Neves M. IFN? and iNOS-Mediated Alterations in the Bone Marrow and Thymus and Its Impact on Mycobacterium avium-Induced Thymic Atrophy. Front Immunol. 2021; 12:696415.

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Ghorbanzadeh H, Mohebkhodaei P, Nematizadeh M, Rahimi N, Rafeiean M, Ghasemi M, Dehpour AR. Analgesic and anti-inflammatory effects of modafinil in a mouse model of neuropathic pain: A role for nitrergic and serotonergic pathways. Neurol Res. 2022 May; 44(5):390-402.

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