The middle segment of proinsulin that is between the N-terminal B-chain and the C-terminal A-chain. It is a pancreatic peptide of about 31 residues, depending on the species. Upon proteolytic cleavage of proinsulin, equimolar INSULIN and C-peptide are released. C-peptide immunoassay has been used to assess pancreatic beta cell function in diabetic patients with circulating insulin antibodies or exogenous insulin. Half-life of C-peptide is 30 min, almost 8 times that of insulin.

Descriptor ID	D002096
MeSH Number(s)	D06.472.699.587.200.500.250 D12.644.548.586.200.500.250
Concept/Terms	C-Peptide C-Peptide C Peptide Connecting Peptide Proinsulin C-Peptide Proinsulin C Peptide C-Peptide, Proinsulin C Peptide, Proinsulin

Below are MeSH descriptors whose meaning is more general than "C-Peptide".

Below are MeSH descriptors whose meaning is related to "C-Peptide".

Below are MeSH descriptors whose meaning is more specific than "C-Peptide".