"HMGA1a Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An 11-kDa AT-hook motif-containing (AT-HOOK MOTIFS) protein that binds to the minor grove of AT-rich regions of DNA. It is the full-length product of the alternatively-spliced HMGA1 gene and may function as an architectural chromatin binding protein that is involved in transcriptional regulation.
| Descriptor ID |
D025741
|
| MeSH Number(s) |
D12.776.260.312.500 D12.776.660.235.400.500.100 D12.776.664.235.400.500.100
|
| Concept/Terms |
HMGA1a Protein- HMGA1a Protein
- High Mobility Group I(Y) Protein
- HMGI(Y) Gene Product
- HMG I-Y Phosphoprotein
- HMG I Y Phosphoprotein
- Phosphoprotein, HMG I-Y
- HMG-I(Y) Protein
- HMGI Protein
- AT-Hook 1a Protein, High Mobility Group
- AT Hook 1a Protein, High Mobility Group
- HMG I-Type Protein
- HMG I Type Protein
|
Below are MeSH descriptors whose meaning is more general than "HMGA1a Protein".
Below are MeSH descriptors whose meaning is more specific than "HMGA1a Protein".
This graph shows the total number of publications written about "HMGA1a Protein" by people in this website by year, and whether "HMGA1a Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2007 | 2 | 0 | 2 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "HMGA1a Protein" by people in Profiles.
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Li M, Tucker LD, Asara JM, Cheruiyot CK, Lu H, Wu ZJ, Newstein MC, Dooner MS, Friedman J, Lally MA, Ramratnam B. Stem-loop binding protein is a multifaceted cellular regulator of HIV-1 replication. J Clin Invest. 2016 08 01; 126(8):3117-29.
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Adair JE, Maloney SC, Dement GA, Wertzler KJ, Smerdon MJ, Reeves R. High-mobility group A1 proteins inhibit expression of nucleotide excision repair factor xeroderma pigmentosum group A. Cancer Res. 2007 Jul 01; 67(13):6044-52.
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Maloney SC, Adair JE, Smerdon MJ, Reeves R. Gene-specific nucleotide excision repair is impaired in human cells expressing elevated levels of high mobility group A1 nonhistone proteins. DNA Repair (Amst). 2007 Sep 01; 6(9):1371-9.
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Adair JE, Kwon Y, Dement GA, Smerdon MJ, Reeves R. Inhibition of nucleotide excision repair by high mobility group protein HMGA1. J Biol Chem. 2005 Sep 16; 280(37):32184-92.
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Treff NR, Dement GA, Adair JE, Britt RL, Nie R, Shima JE, Taylor WE, Reeves R. Human KIT ligand promoter is positively regulated by HMGA1 in breast and ovarian cancer cells. Oncogene. 2004 Nov 04; 23(52):8557-62.