Immunotoxins

"Immunotoxins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Semisynthetic conjugates of various toxic molecules, including RADIOACTIVE ISOTOPES and bacterial or plant toxins, with specific immune substances such as IMMUNOGLOBULINS; MONOCLONAL ANTIBODIES; and ANTIGENS. The antitumor or antiviral immune substance carries the toxin to the tumor or infected cell where the toxin exerts its poisonous effect.

Descriptor ID	D000922
MeSH Number(s)	D12.776.124.790.651.114.580.450 D12.776.377.715.548.114.580.450 D27.888.569.271
Concept/Terms	Immunotoxins Immunotoxins Cytotoxin-Antibody Conjugates Conjugates, Cytotoxin-Antibody Cytotoxin Antibody Conjugates Immunotoxin Antibody-Toxin Hybrids Antibody Toxin Hybrids Hybrids, Antibody-Toxin Affinotoxins Antibody-Toxin Conjugates Antibody Toxin Conjugates Conjugates, Antibody-Toxin Toxin-Antibody Conjugates Conjugates, Toxin-Antibody Toxin Antibody Conjugates Toxin-Antibody Hybrids Hybrids, Toxin-Antibody Toxin Antibody Hybrids Monoclonal Antibody-Toxin Conjugates Antibody-Toxin Conjugates, Monoclonal Conjugates, Monoclonal Antibody-Toxin Monoclonal Antibody Toxin Conjugates Targeted Toxins Targeted Toxins Toxins, Targeted Toxins, Chimeric Toxins, Chimeric Chimeric Toxins Toxin Conjugates Conjugates, Toxin Toxin Carriers Carriers, Toxin Toxin Conjugate Conjugate, Toxin Chimeric Toxin Toxin, Chimeric Toxin Carrier Carrier, Toxin

Below are MeSH descriptors whose meaning is more general than "Immunotoxins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Serum Globulins [D12.776.124.790]
Immunoglobulins [D12.776.124.790.651]
Antibodies [D12.776.124.790.651.114]
Immunoconjugates [D12.776.124.790.651.114.580]
Immunotoxins [D12.776.124.790.651.114.580.450]
Globulins [D12.776.377]
Serum Globulins [D12.776.377.715]
Immunoglobulins [D12.776.377.715.548]
Antibodies [D12.776.377.715.548.114]
Immunoconjugates [D12.776.377.715.548.114.580]
Immunotoxins [D12.776.377.715.548.114.580.450]
Chemical Actions and Uses [D27]
Toxic Actions [D27.888]
Noxae [D27.888.569]
Immunotoxins [D27.888.569.271]

Below are MeSH descriptors whose meaning is related to "Immunotoxins".

Below are MeSH descriptors whose meaning is more specific than "Immunotoxins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Immunotoxins" by people in this website by year, and whether "Immunotoxins" was a major or minor topic of these publications.

Bar chart showing 7 publications over 7 distinct years, with a maximum of 1 publications in 1996 and 1997 and 1998 and 1999 and 2004 and 2005 and 2023

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1997	0	1	1
1998	1	0	1
1999	1	0	1
2004	0	1	1
2005	1	0	1
2023	1	0	1

Below are the most recent publications written about "Immunotoxins" by people in Profiles.

Zhu K, Mukherjee K, Wei C, Hayek SS, Collins A, Gu C, Corapi K, Altintas MM, Wang Y, Waikar SS, Bianco AC, Koch A, Tacke F, Reiser J, Sever S. The D2D3 form of uPAR acts as an immunotoxin and may cause diabetes and kidney disease. Sci Transl Med. 2023 09 20; 15(714):eabq6492.

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Merriam D, Chen C, M?ndez-Lagares G, Rogers KA, Michaels AJ, Yan J, Casaz P, Reimann KA, Villinger F, Hartigan-O'Connor DJ. Depletion of Gut-Resident CCR5+ Cells for HIV Cure Strategies. AIDS Res Hum Retroviruses. 2017 Nov; 33(S1):S70-S80.

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Burris HA, Rugo HS, Vukelja SJ, Vogel CL, Borson RA, Limentani S, Tan-Chiu E, Krop IE, Michaelson RA, Girish S, Amler L, Zheng M, Chu YW, Klencke B, O'Shaughnessy JA. Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy. J Clin Oncol. 2011 Feb 01; 29(4):398-405.

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Wang X, Ko EC, Peng L, Gillies SD, Ferrone S. Human high molecular weight melanoma-associated antigen mimicry by mouse anti-idiotypic monoclonal antibody MK2-23: enhancement of immunogenicity of anti-idiotypic monoclonal antibody MK2-23 by fusion with interleukin 2. Cancer Res. 2005 Aug 01; 65(15):6976-83.

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Tsai HF, Lai JJ, Chou AH, Wang TF, Wu CS, Hsu PN. Induction of costimulation of human CD4 T cells by tumor necrosis factor-related apoptosis-inducing ligand: possible role in T cell activation in systemic lupus erythematosus. Arthritis Rheum. 2004 Feb; 50(2):629-39.

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Knechtle SJ, Kirk AD, Fechner JH, Hong X, Dong Y, Hamawy MM, Harlan DM. Inducing unresponsiveness by the use of anti-CD3 immunotoxin, CTLA4-Ig, and anti-CD40 ligand. Transplant Proc. 1999 May; 31(3B Suppl):27S-28S.

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Marecos E, Weissleder R, Bogdanov A. Antibody-mediated versus nontargeted delivery in a human small cell lung carcinoma model. Bioconjug Chem. 1998 Mar-Apr; 9(2):184-91.

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Kershaw GR, Berger C, McQuain C, al-Homsi AS, Pihan G, Quesenberry PJ, Woda BA, Knecht H. Selective outgrowth of a posttransplant B-immunoblastic lymphoma expressing a latent membrane protein-1 deletion variant. Transplantation. 1997 Oct 15; 64(7):1079-81.

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Donta ST, Peduzzi P, Cross AS, Sadoff J, Haakenson C, Cryz SJ, Kauffman C, Bradley S, Gafford G, Elliston D, Beam TR, John JF, Ribner B, Cantey R, Welsh CH, Ellison RT, Young EJ, Hamill RJ, Leaf H, Schein RM, Mulligan M, Johnson C, Abrutyn E, Griffiss JM, Slagle D, et al. Immunoprophylaxis against klebsiella and pseudomonas aeruginosa infections. The Federal Hyperimmune Immunoglobulin Trial Study Group. J Infect Dis. 1996 Sep; 174(3):537-43.

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Liu C, Tadayoni BM, Bourret LA, Mattocks KM, Derr SM, Widdison WC, Kedersha NL, Ariniello PD, Goldmacher VS, Lambert JM, Bl?ttler WA, Chari RV. Eradication of large colon tumor xenografts by targeted delivery of maytansinoids. Proc Natl Acad Sci U S A. 1996 Aug 06; 93(16):8618-23.

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