Clonal Deletion

"Clonal Deletion" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Removal, via CELL DEATH, of immature lymphocytes that interact with antigens during maturation. For T-lymphocytes this occurs in the thymus and ensures that mature T-lymphocytes are self tolerant. B-lymphocytes may also undergo clonal deletion.

Descriptor ID	D017637
MeSH Number(s)	G12.535.425.120
Concept/Terms	Clonal Deletion Clonal Deletion Clonal Deletions Deletion, Clonal Deletions, Clonal Clonal Abortion Clonal Abortion Abortion, Clonal Abortions, Clonal Clonal Abortions

Below are MeSH descriptors whose meaning is more general than "Clonal Deletion".

Biological Sciences [G]
Immune System Phenomena [G12]
Immunomodulation [G12.535]
Immune Tolerance [G12.535.425]
Clonal Deletion [G12.535.425.120]

Below are MeSH descriptors whose meaning is related to "Clonal Deletion".

Below are MeSH descriptors whose meaning is more specific than "Clonal Deletion".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Clonal Deletion" by people in this website by year, and whether "Clonal Deletion" was a major or minor topic of these publications.

Bar chart showing 9 publications over 7 distinct years, with a maximum of 3 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	1	0	1
2001	1	0	1
2004	1	2	3
2006	0	1	1
2008	1	0	1
2018	0	1	1
2025	0	1	1

Below are the most recent publications written about "Clonal Deletion" by people in Profiles.

Stadinski BD, Mills EA, Humphries PA, Cleveland SB, Dow P, Murakami K, Li YR, Murakami M, Ono M, Au-Yeung BB, Morris GP, Z??iga-Pfl?cker JC, Campbell RA, Griffiths ER, Huseby ES, Lo WL. Age-dependent Zap70 expression in thymocytes regulates selection of the neonatal regulatory T cell repertoire. Nat Immunol. 2025 Dec; 26(12):2256-2269.

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Presa M, Racine JJ, Dwyer JR, Lamont DJ, Ratiu JJ, Sarsani VK, Chen YG, Geurts A, Schmitz I, Stearns T, Allocco J, Chapman HD, Serreze DV. A Hypermorphic Nfkbid Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8+ T Cells in NOD Mice. J Immunol. 2018 10 01; 201(7):1907-1917.

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Serreze DV, Choisy-Rossi CM, Grier AE, Holl TM, Chapman HD, Gahagan JR, Osborne MA, Zhang W, King BL, Brown A, Roopenian D, Marron MP. Through regulation of TCR expression levels, an Idd7 region gene(s) interactively contributes to the impaired thymic deletion of autoreactive diabetogenic CD8+ T cells in nonobese diabetic mice. J Immunol. 2008 Mar 01; 180(5):3250-9.

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Thornley TB, Brehm MA, Markees TG, Shultz LD, Mordes JP, Welsh RM, Rossini AA, Greiner DL. TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts. J Immunol. 2006 Feb 01; 176(3):1561-70.

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Choisy-Rossi CM, Holl TM, Pierce MA, Chapman HD, Serreze DV. Enhanced pathogenicity of diabetogenic T cells escaping a non-MHC gene-controlled near death experience. J Immunol. 2004 Sep 15; 173(6):3791-800.

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Huseby E, Kappler J, Marrack P. TCR-MHC/peptide interactions: kissing-cousins or a shotgun wedding? Eur J Immunol. 2004 May; 34(5):1243-50.

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Silveira PA, Dombrowsky J, Johnson E, Chapman HD, Nemazee D, Serreze DV. B cell selection defects underlie the development of diabetogenic APCs in nonobese diabetic mice. J Immunol. 2004 Apr 15; 172(8):5086-94.

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Trimble LA, Prince KA, Pestano GA, Daley J, Cantor H. Fas-dependent elimination of nonselected CD8 cells and lpr disease. J Immunol. 2002 May 15; 168(10):4960-7.

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Riese RJ, Shi GP, Villadangos J, Stetson D, Driessen C, Lennon-Dumenil AM, Chu CL, Naumov Y, Behar SM, Ploegh H, Locksley R, Chapman HA. Regulation of CD1 function and NK1.1(+) T cell selection and maturation by cathepsin S. Immunity. 2001 Dec; 15(6):909-19.

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Wekerle T, Sayegh MH, Hill J, Zhao Y, Chandraker A, Swenson KG, Zhao G, Sykes M. Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance. J Exp Med. 1998 Jun 15; 187(12):2037-44.

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