NF-E2-Related Factor 2

"NF-E2-Related Factor 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A basic-leucine zipper transcription factor that was originally described as a transcriptional regulator controlling expression of the BETA-GLOBIN gene. It may regulate the expression of a wide variety of genes that play a role in protecting cells from oxidative damage.

Descriptor ID	D051267
MeSH Number(s)	D12.776.260.108.737 D12.776.930.127.737
Concept/Terms	NF-E2-Related Factor 2 NF-E2-Related Factor 2 NF E2 Related Factor 2 Nuclear Factor E2-Related Factor 2 Nuclear Factor E2 Related Factor 2 Nfe2l2 Protein Nuclear Factor (Erythroid-Derived 2)-Like 2 Protein

Below are MeSH descriptors whose meaning is more general than "NF-E2-Related Factor 2".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Basic-Leucine Zipper Transcription Factors [D12.776.260.108]
NF-E2-Related Factor 2 [D12.776.260.108.737]
Transcription Factors [D12.776.930]
Basic-Leucine Zipper Transcription Factors [D12.776.930.127]
NF-E2-Related Factor 2 [D12.776.930.127.737]

Below are MeSH descriptors whose meaning is related to "NF-E2-Related Factor 2".

Below are MeSH descriptors whose meaning is more specific than "NF-E2-Related Factor 2".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "NF-E2-Related Factor 2" by people in this website by year, and whether "NF-E2-Related Factor 2" was a major or minor topic of these publications.

Bar chart showing 23 publications over 11 distinct years, with a maximum of 4 publications in 2018 and 2025

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2008	0	1	1
2016	2	0	2
2017	2	1	3
2018	2	2	4
2019	1	0	1
2020	0	1	1
2022	0	1	1
2023	1	1	2
2024	2	0	2
2025	3	1	4
2026	2	0	2

Below are the most recent publications written about "NF-E2-Related Factor 2" by people in Profiles.

Pham LK, Cervantes MM, Lim PN, Dubey D, Tufts A, Mitchell MC, Shinkawa T, Behar SM, Rothchild AC. NRF2-mediated inhibition of alveolar macrophage MHC II expression during Mycobacterium tuberculosis infection. Cell Rep. 2026 Jun 23; 45(6):117397.

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Lin YY, Kuo HH, He ZJ, Chung HY, Kim CH, Pan YR, Wu MJ, Chan MH, Yeh CN, Chiang NJ, Chen MH, Chang YC. SLC25A11-mediated reprogramming of mitochondrial redox state and lipid peroxidation confers NRF2-dependent ferroptosis resistance in biliary tract cancer. Cell Mol Biol Lett. 2026 Jan 09; 31(1).

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Kumar A, Kishimoto K, Goel HL, Silva CA, Li R, Pacheco B, Zhu LJ, Flavahan WA, Mercurio AM. Resistance to radiation enhances metastasis by altering RNA metabolism. Sci Adv. 2025 Oct 17; 11(42):eadx3050.

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Dai Q, Xiang Y, Qiang R, Li G, Song Y, Yu Y, Liu J, Lv M, Liu W, Zhao J, Wei X, Liu X. Aloe-emodin mitigates cisplatin-induced acute kidney injury by Nrf2-mediated ferroptosis regulation. Free Radic Biol Med. 2025 12 16; 241:104-116.

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Malekshahi M, Meskar Z, Manavi MA, Lesani A, Mohammad Jafari R, Ghasemi M, Dehpour AR. Anticonvulsant effects of noscapine against status epilepticus induced by lithium-pilocarpine in rats: involvement of Nrf2/HO-1 and NLRP3 pathways. Naunyn Schmiedebergs Arch Pharmacol. 2025 Oct; 398(10):14291-14300.

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Jiao Q, Liu J, Zhou L, McClements DJ, Liu W, Luo J, Peng S. Lactobacillus extracellular vesicles alleviate alcohol-induced liver injury in mice by regulating gut microbiota and activating the Nrf-2 signaling pathway. Food Funct. 2025 Feb 17; 16(4):1284-1298.

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Kumar A, Goel HL, Silva CA, Wang T, Geng Y, Wang M, Goel S, Hu K, Li R, Zhu LJ, Clark JL, Ferreira LM, Brehm MA, FitzGerald TJ, Mercurio AM. Neuropilin-2-expressing breast cancer cells mitigate radiation-induced oxidative stress through nitric oxide signaling. J Clin Invest. 2024 10 01; 134(22).

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Zhai S, Zhang X, Jiang M, Liu Y, Qu G, Cui X, Hirschbiegel CM, Liu Y, Alves C, Lee YW, Jiang G, Yan B, Rotello VM. Nanoparticles with intermediate hydrophobicity polarize macrophages to plaque-specific Mox phenotype via Nrf2 and HO-1 activation. J Hazard Mater. 2024 03 15; 466:133590.

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Huang J, Zhu Y, Li S, Jiang H, Chen N, Xiao H, Liu J, Liang D, Zheng Q, Tang J, Meng X. Licochalcone B confers protective effects against LPS-Induced acute lung injury in cells and mice through the Keap1/Nrf2 pathway. Redox Rep. 2023 Dec; 28(1):2243423.

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Wang R, Fortier TM, Chai F, Miao G, Shen JL, Restrepo LJ, DiGiacomo JJ, Velentzas PD, Baehrecke EH. PINK1, Keap1, and Rtnl1 regulate selective clearance of endoplasmic reticulum during development. Cell. 2023 09 14; 186(19):4172-4188.e18.

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