Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice.

Venkatesh A, Ma S, Le YZ, Hall MN, R?egg MA, Punzo C. Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice. J Clin Invest. 2015 Apr; 125(4):1446-58.

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subject areas

Adaptor Proteins, Signal Transducing
Animals
Apoptosis
Caspase 2
Cell Survival
Glucose
Insulin
Mechanistic Target of Rapamycin Complex 1
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Mutant Strains
Models, Neurological
Multiprotein Complexes
NADP
PTEN Phosphohydrolase
Regulatory-Associated Protein of mTOR
Retinal Cone Photoreceptor Cells
Retinal Rod Photoreceptor Cells
Retinitis Pigmentosa
Signal Transduction
TOR Serine-Threonine Kinases

authors with profiles

Claudio Punzo PhD