A forkhead box transcription factor that is a major target of INSULIN signaling and regulator of metabolic homeostasis in response to OXIDATIVE STRESS. It binds to the insulin RESPONSE ELEMENT (IRE) and the related Daf-16 family binding element (DBE). Its activity is suppressed by insulin and it also regulates OSTEOBLAST proliferation, controls bone mass, and skeletal regulation of GLUCOSE metabolism. It promotes GLUCONEOGENESIS in HEPATOCYTES and regulates gene expression in ADIPOSE TISSUE. It is also an important CELL DEATH regulator. Chromosomal aberrations involving the FOXO1 gene occur in RHABDOMYOSARCOMA.

Descriptor ID	D000071161
MeSH Number(s)	D12.776.260.950.249.250 D12.776.930.977.249.250
Concept/Terms	Forkhead Box Protein O1 Forkhead Box Protein O1 Forkhead in Rhabdomyosarcoma Protein FOXO1 Protein

Below are MeSH descriptors whose meaning is more general than "Forkhead Box Protein O1".

Below are MeSH descriptors whose meaning is related to "Forkhead Box Protein O1".

Below are MeSH descriptors whose meaning is more specific than "Forkhead Box Protein O1".