Zinc Finger Protein Gli2

"Zinc Finger Protein Gli2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A transcriptional activator that contains five adjacent CYS2-HIS2 ZINC FINGERS. It functions in the hedgehog signaling pathway and is required for normal embryonic development. Mutations in the GLI2 gene are associated with type 9 HOLOPROSENCEPHALY and type 2 PALLISTER-HALL SYNDROME.

Descriptor ID	D000075746
MeSH Number(s)	D12.776.260.755.925 D12.776.930.900.850
Concept/Terms	Zinc Finger Protein Gli2 Zinc Finger Protein Gli2 Gli2 Protein

Below are MeSH descriptors whose meaning is more general than "Zinc Finger Protein Gli2".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Trans-Activators [D12.776.260.755]
Zinc Finger Protein Gli2 [D12.776.260.755.925]
Transcription Factors [D12.776.930]
Trans-Activators [D12.776.930.900]
Zinc Finger Protein Gli2 [D12.776.930.900.850]

Below are MeSH descriptors whose meaning is related to "Zinc Finger Protein Gli2".

Below are MeSH descriptors whose meaning is more specific than "Zinc Finger Protein Gli2".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Zinc Finger Protein Gli2" by people in this website by year, and whether "Zinc Finger Protein Gli2" was a major or minor topic of these publications.

Bar chart showing 21 publications over 15 distinct years, with a maximum of 3 publications in 2008 and 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
1999	0	1	1
2000	0	1	1
2003	0	1	1
2004	0	1	1
2005	0	1	1
2006	0	2	2
2008	0	3	3
2009	0	1	1
2011	0	1	1
2012	0	1	1
2013	0	3	3
2015	0	1	1
2016	1	1	2
2024	1	0	1

Below are the most recent publications written about "Zinc Finger Protein Gli2" by people in Profiles.

Sigafoos AN, Tolosa EJ, Carr RM, Fernandez-Barrena MG, Almada LL, Pease DR, Hogenson TL, Raja Arul GL, Mousavi F, Sen S, Vera RE, Marks DL, Flores LF, LaRue-Nolan KC, Wu C, Bamlet WR, Vrabel AM, Sicotte H, Schenk EL, Smyrk TC, Zhang L, Rabe KG, Oberg AL, Zaphiropoulos PG, Chevet E, Graham RP, Hagen CE, di Magliano MP, Elsawa SF, Pin CL, Mao J, McWilliams RR, Fernandez-Zapico ME. KRAS Promotes GLI2-Dependent Transcription during Pancreatic Carcinogenesis. Cancer Res Commun. 2024 07 01; 4(7):1677-1689.

View in: PubMed
Tang CM, Lee TE, Syed SA, Burgoyne AM, Leonard SY, Gao F, Chan JC, Shi E, Chmielecki J, Morosini D, Wang K, Ross JS, Kendrick ML, Bardsley MR, Siena M, Mao J, Harismendy O, Ordog T, Sicklick JK. Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression. Oncotarget. 2016 Nov 29; 7(48):78226-78241.

View in: PubMed
Liu X, Pitarresi JR, Cuiti?o MC, Kladney RD, Woelke SA, Sizemore GM, Nayak SG, Egriboz O, Schweickert PG, Yu L, Trela S, Schilling DJ, Halloran SK, Li M, Dutta S, Fernandez SA, Rosol TJ, Lesinski GB, Shakya R, Ludwig T, Konieczny SF, Leone G, Wu J, Ostrowski MC. Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia. Genes Dev. 2016 09 01; 30(17):1943-55.

View in: PubMed
Yang N, Li L, Eguether T, Sundberg JP, Pazour GJ, Chen J. Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis. Development. 2015 Jun 15; 142(12):2194-202.

View in: PubMed
Rajurkar M, Huang H, Cotton JL, Brooks JK, Sicklick J, McMahon AP, Mao J. Distinct cellular origin and genetic requirement of Hedgehog-Gli in postnatal rhabdomyosarcoma genesis. Oncogene. 2014 Nov 13; 33(46):5370-8.

View in: PubMed
Himeda CL, Barro MV, Emerson CP. Pax3 synergizes with Gli2 and Zic1 in transactivating the Myf5 epaxial somite enhancer. Dev Biol. 2013 Nov 01; 383(1):7-14.

View in: PubMed
Huang H, Cotton JL, Wang Y, Rajurkar M, Zhu LJ, Lewis BC, Mao J. Specific requirement of Gli transcription factors in Hedgehog-mediated intestinal development. J Biol Chem. 2013 Jun 14; 288(24):17589-96.

View in: PubMed
Keady BT, Samtani R, Tobita K, Tsuchya M, San Agustin JT, Follit JA, Jonassen JA, Subramanian R, Lo CW, Pazour GJ. IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport. Dev Cell. 2012 May 15; 22(5):940-51.

View in: PubMed
Raz G, Allen KE, Kingsley C, Cherni I, Arora S, Watanabe A, Lorenzo CD, Edwards V DK, Sridhar S, Hostetter G, Weiss GJ. Hedgehog signaling pathway molecules and ALDH1A1 expression in early-stage non-small cell lung cancer. Lung Cancer. 2012 May; 76(2):191-6.

View in: PubMed
Clement CA, Kristensen SG, M?llg?rd K, Pazour GJ, Yoder BK, Larsen LA, Christensen ST. The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation. J Cell Sci. 2009 Sep 01; 122(Pt 17):3070-82.

View in: PubMed

People

Explore

Similar Concepts

Top Journals