Histone Deacetylase 6

"Histone Deacetylase 6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A class II histone deacetylase that removes acetyl groups from N-terminal LYSINES of HISTONE H2A; HISTONE H2B; HISTONE H3; and HISTONE H4. It plays a critical role in EPIGENETIC REPRESSION and regulation of GENETIC TRANSCRIPTION, as well as CELL MOTILITY through deacetylation of TUBULIN. It also targets misfolded proteins for clearance by AUTOPHAGY when MOLECULAR CHAPERONE-mediated folding is overwhelmed.

Descriptor ID	D000073864
MeSH Number(s)	D08.811.277.087.520.350
Concept/Terms	Histone Deacetylase 6 Histone Deacetylase 6

Below are MeSH descriptors whose meaning is more general than "Histone Deacetylase 6".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Amidohydrolases [D08.811.277.087]
Histone Deacetylases [D08.811.277.087.520]
Histone Deacetylase 6 [D08.811.277.087.520.350]

Below are MeSH descriptors whose meaning is related to "Histone Deacetylase 6".

Below are MeSH descriptors whose meaning is more specific than "Histone Deacetylase 6".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Histone Deacetylase 6" by people in this website by year, and whether "Histone Deacetylase 6" was a major or minor topic of these publications.

Bar chart showing 7 publications over 6 distinct years, with a maximum of 2 publications in 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2007	0	2	2
2013	0	1	1
2019	1	0	1
2020	1	0	1
2026	1	0	1

Below are the most recent publications written about "Histone Deacetylase 6" by people in Profiles.

James RE, Bekier M, Lee PJ, Schroeder FA, Evans LT, Wagner FF, Hickman D, Richardson T, Hatzipetros T, Vieira F, Callizot N, Modi S, Hooker JM, Kranz JE, Brown RH, Barmada SJ, Gilbert TM. A next-generation HDAC6 inhibitor for amyotrophic lateral sclerosis and frontotemporal dementia. Brain. 2026 May 05; 149(5):1586-1603.

View in: PubMed
Magupalli VG, Negro R, Tian Y, Hauenstein AV, Di Caprio G, Skillern W, Deng Q, Orning P, Alam HB, Maliga Z, Sharif H, Hu JJ, Evavold CL, Kagan JC, Schmidt FI, Fitzgerald KA, Kirchhausen T, Li Y, Wu H. HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation. Science. 2020 09 18; 369(6510).

View in: PubMed
Lundh M, Petersen PS, Isidor MS, Kazoka-S?rensen DN, Plucinska K, Shamsi F, ?rskov C, Tozzi M, Brown EL, Andersen E, Ma T, M?ller U, Barr?s R, Kristiansen VB, Gerhart-Hines Z, Tseng YH, Emanuelli B. Afadin is a scaffold protein repressing insulin action via HDAC6 in adipose tissue. EMBO Rep. 2019 08; 20(8):e48216.

View in: PubMed
Chen PB, Hung JH, Hickman TL, Coles AH, Carey JF, Weng Z, Chu F, Fazzio TG. Hdac6 regulates Tip60-p400 function in stem cells. Elife. 2013 Dec 03; 2:e01557.

View in: PubMed
Pandey UB, Batlevi Y, Baehrecke EH, Taylor JP. HDAC6 at the intersection of autophagy, the ubiquitin-proteasome system and neurodegeneration. Autophagy. 2007 Nov-Dec; 3(6):643-5.

View in: PubMed
Pandey UB, Nie Z, Batlevi Y, McCray BA, Ritson GP, Nedelsky NB, Schwartz SL, DiProspero NA, Knight MA, Schuldiner O, Padmanabhan R, Hild M, Berry DL, Garza D, Hubbert CC, Yao TP, Baehrecke EH, Taylor JP. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature. 2007 Jun 14; 447(7146):859-63.

View in: PubMed
Westendorf JJ, Zaidi SK, Cascino JE, Kahler R, van Wijnen AJ, Lian JB, Yoshida M, Stein GS, Li X. Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter. Mol Cell Biol. 2002 Nov; 22(22):7982-92.

View in: PubMed

People

Explore

Similar Concepts

Top Journals