HLA-DRB1 Chains

"HLA-DRB1 Chains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A subtype of HLA-DRB beta chains that includes over one hundred allele variants. The HLA-DRB1 subtype is associated with several of the HLA-DR SEROLOGICAL SUBTYPES.

Descriptor ID	D059811
MeSH Number(s)	D12.776.395.550.509.400.440.200.010 D12.776.543.550.440.400.440.200.010 D23.050.301.500.400.400.440.200.010 D23.050.301.500.450.400.440.333.500 D23.050.705.552.410.400.440.200.010 D23.050.705.552.450.400.440.333.500
Concept/Terms	HLA-DRB1 Chains HLA-DRB1 Chains Chains, HLA-DRB1 HLA DRB1 Chains HLA-DRB1 Antigen Antigen, HLA-DRB1 HLA DRB1 Antigen HLA DRB1 HLA-DRB1

Below are MeSH descriptors whose meaning is more general than "HLA-DRB1 Chains".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Glycoproteins [D12.776.395]
Membrane Glycoproteins [D12.776.395.550]
Histocompatibility Antigens Class II [D12.776.395.550.509]
HLA-D Antigens [D12.776.395.550.509.400]
HLA-DR Antigens [D12.776.395.550.509.400.440]
HLA-DR beta-Chains [D12.776.395.550.509.400.440.200]
HLA-DRB1 Chains [D12.776.395.550.509.400.440.200.010]
Membrane Proteins [D12.776.543]
Membrane Glycoproteins [D12.776.543.550]
Histocompatibility Antigens Class II [D12.776.543.550.440]
HLA-D Antigens [D12.776.543.550.440.400]
HLA-DR Antigens [D12.776.543.550.440.400.440]
HLA-DR beta-Chains [D12.776.543.550.440.400.440.200]
HLA-DRB1 Chains [D12.776.543.550.440.400.440.200.010]
Biological Factors [D23]
Antigens [D23.050]
Antigens, Surface [D23.050.301]
Histocompatibility Antigens [D23.050.301.500]
Histocompatibility Antigens Class II [D23.050.301.500.400]
HLA-D Antigens [D23.050.301.500.400.400]
HLA-DR Antigens [D23.050.301.500.400.400.440]
HLA-DR beta-Chains [D23.050.301.500.400.400.440.200]
HLA-DRB1 Chains [D23.050.301.500.400.400.440.200.010]
HLA Antigens [D23.050.301.500.450]
HLA-D Antigens [D23.050.301.500.450.400]
HLA-DR Antigens [D23.050.301.500.450.400.440]
HLA-DR beta-Chains [D23.050.301.500.450.400.440.333]
HLA-DRB1 Chains [D23.050.301.500.450.400.440.333.500]
Isoantigens [D23.050.705]
Histocompatibility Antigens [D23.050.705.552]
Histocompatibility Antigens Class II [D23.050.705.552.410]
HLA-D Antigens [D23.050.705.552.410.400]
HLA-DR Antigens [D23.050.705.552.410.400.440]
HLA-DR beta-Chains [D23.050.705.552.410.400.440.200]
HLA-DRB1 Chains [D23.050.705.552.410.400.440.200.010]
HLA Antigens [D23.050.705.552.450]
HLA-D Antigens [D23.050.705.552.450.400]
HLA-DR Antigens [D23.050.705.552.450.400.440]
HLA-DR beta-Chains [D23.050.705.552.450.400.440.333]
HLA-DRB1 Chains [D23.050.705.552.450.400.440.333.500]

Below are MeSH descriptors whose meaning is related to "HLA-DRB1 Chains".

Below are MeSH descriptors whose meaning is more specific than "HLA-DRB1 Chains".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "HLA-DRB1 Chains" by people in this website by year, and whether "HLA-DRB1 Chains" was a major or minor topic of these publications.

Bar chart showing 16 publications over 12 distinct years, with a maximum of 2 publications in 2005 and 2011 and 2015 and 2025

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
2000	1	1
2005	2	2
2006	1	1
2008	1	1
2009	1	1
2011	2	2
2013	1	1
2014	1	1
2015	2	2
2018	1	1
2023	1	1
2025	2	2

Below are the most recent publications written about "HLA-DRB1 Chains" by people in Profiles.

Guyer P, Seminova K, Lugar M, Manganaro A, Velarde de la Cruz EE, Hartley R, Smithmyer ME, Speake C, Bonifacio E, Kent SC, James EA. T cell and autoantibody recognition of nucleus-associated islet autoantigens in individuals with type 1 diabetes. Diabetologia. 2025 Aug; 68(8):1721-1734.

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Ganta KK, McManus M, Blanc R, Wang Q, Jung W, Brody R, Carrington M, Paris R, Chandramouli S, McNamara RP, Luzuriaga K. Acute infectious mononucleosis generates persistent, functional EBNA-1 antibodies with high cross-reactivity to alpha-crystalline beta. Cell Rep. 2025 May 27; 44(5):115709.

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Ho A, Orton R, Tayler R, Asamaphan P, Herder V, Davis C, Tong L, Smollett K, Manali M, Allan J, Rawlik K, McDonald SE, Vink E, Pollock L, Gannon L, Evans C, McMenamin J, Roy K, Marsh K, Divala T, Holden MTG, Lockhart M, Yirrell D, Currie S, O'Leary M, Henderson D, Shepherd SJ, Jackson C, Gunson R, MacLean A, McInnes N, Bradley-Stewart A, Battle R, Hollenbach JA, Henderson P, Odam M, Chikowore P, Oosthuyzen W, Chand M, Hamilton MS, Estrada-Rivadeneyra D, Levin M, Avramidis N, Pairo-Castineira E, Vitart V, Wilkie C, Palmarini M, Ray S, Robertson DL, da Silva Filipe A, Willett BJ, Breuer J, Semple MG, Turner D, Baillie JK, Thomson EC. Adeno-associated virus 2 infection in children with non-A-E hepatitis. Nature. 2023 05; 617(7961):555-563.

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Aliseychik MP, Andreeva TV, Rogaev EI. Immunogenetic Factors of Neurodegenerative Diseases: The Role of HLA Class II. Biochemistry (Mosc). 2018 Sep; 83(9):1104-1116.

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Becerra-Artiles A, Dominguez-Amorocho O, Stern LJ, Calvo-Calle JM. A Simple Proteomics-Based Approach to Identification of Immunodominant Antigens from a Complex Pathogen: Application to the CD4 T Cell Response against Human Herpesvirus 6B. PLoS One. 2015; 10(11):e0142871.

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Chang ALS, Raber I, Xu J, Li R, Spitale R, Chen J, Kiefer AK, Tian C, Eriksson NK, Hinds DA, Tung JY. Assessment of the genetic basis of rosacea by genome-wide association study. J Invest Dermatol. 2015 Jun; 135(6):1548-1555.

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Gonzalez SM, Payne JB, Yu F, Thiele GM, Erickson AR, Johnson PG, Schmid MJ, Cannon GW, Kerr GS, Reimold AM, Sokolove J, Robinson WH, Mikuls TR. Alveolar bone loss is associated with circulating anti-citrullinated protein antibody (ACPA) in patients with rheumatoid arthritis. J Periodontol. 2015 Feb; 86(2):222-31.

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Yin L, Stern LJ. A novel method to measure HLA-DM-susceptibility of peptides bound to MHC class II molecules based on peptide binding competition assay and differential IC(50) determination. J Immunol Methods. 2014 Apr; 406:21-33.

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Kuller LH, Mackey RH, Walitt BT, Deane KD, Holers VM, Robinson WH, Sokolove J, Chang Y, Moreland LW. Rheumatoid arthritis in the Women's Health Initiative: methods and baseline evaluation. Am J Epidemiol. 2014 Apr 01; 179(7):917-26.

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Wagner CA, Sokolove J, Lahey LJ, Bengtsson C, Saevarsdottir S, Alfredsson L, Delanoy M, Lindstrom TM, Walker RP, Bromberg R, Chandra PE, Binder SR, Klareskog L, Robinson WH. Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis: association with cigarette smoking and HLA-DRB1 'shared epitope' alleles. Ann Rheum Dis. 2015 Mar; 74(3):579-86.

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