MEF2 Transcription Factors

"MEF2 Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Activating transcription factors of the MADS family which bind a specific sequence element (MEF2 element) in many muscle-specific genes and are involved in skeletal and cardiac myogenesis, neuronal differentiation and survival/apoptosis.

Descriptor ID	D064326
MeSH Number(s)	D12.776.210.500.570.294 D12.776.260.103.750.294 D12.776.260.400.249.624 D12.776.930.125.750.294 D12.776.930.397.700
Concept/Terms	MEF2 Transcription Factors MEF2 Transcription Factors Transcription Factors, MEF2 Muscle Enhancer Factor-2 Enhancer Factor-2, Muscle Muscle Enhancer Factor 2 Myocyte-Specific Enhancer-Binding Factor 2 Myocyte Specific Enhancer Binding Factor 2 Myocyte Enhancer Factor 2 Myocyte-Specific Enhancer Factor 2 Myocyte Specific Enhancer Factor 2 MEF2 Proteins Muscle-Specific Enhancer Factor-2 Enhancer Factor-2, Muscle-Specific Muscle Specific Enhancer Factor 2 MEF2B Transcription Factor MEF2B Transcription Factor Transcription Factor, MEF2B Serum Response Factor-Like Protein 2 Serum Response Factor Like Protein 2 Myocyte-Specific Enhancer Factor 2B Myocyte Specific Enhancer Factor 2B Muscle Enhancer Factor-2B Enhancer Factor-2B, Muscle Muscle Enhancer Factor 2B Muscle-Specific Enhancer Factor-2B Enhancer Factor-2B, Muscle-Specific Muscle Specific Enhancer Factor 2B Myocyte Enhancer Factor 2B Myocyte-Specific Enhancer-Binding Factor 2B Myocyte Specific Enhancer Binding Factor 2B MEF2B Protein MEF2D Transcription Factor MEF2D Transcription Factor Transcription Factor, MEF2D Muscle Enhancer Factor-2D Enhancer Factor-2D, Muscle Muscle Enhancer Factor 2D Muscle-Specific Enhancer Factor-2D Enhancer Factor-2D, Muscle-Specific Muscle Specific Enhancer Factor 2D Myocyte-Specific Enhancer Factor 2D Myocyte Specific Enhancer Factor 2D Myocyte-Specific Enhancer-Binding Factor 2D Myocyte Specific Enhancer Binding Factor 2D MEF2D Protein Myocyte Enhancer Factor 2D MEF2A Transcription Factor MEF2A Transcription Factor Transcription Factor, MEF2A Muscle Enhancer Factor-2A Enhancer Factor-2A, Muscle Muscle Enhancer Factor 2A Serum Response Factor-Like Protein 1 Serum Response Factor Like Protein 1 Myocyte Enhancer Factor 2A Myocyte-Specific Enhancer Factor 2A Myocyte Specific Enhancer Factor 2A Myocyte-Specific Enhancer-Binding Factor 2A Myocyte Specific Enhancer Binding Factor 2A MEF2A Protein Muscle-Specific Enhancer Factor-2A Enhancer Factor-2A, Muscle-Specific Muscle Specific Enhancer Factor 2A MEF2C Transcription Factor MEF2C Transcription Factor Transcription Factor, MEF2C Muscle Enhancer Factor-2C Enhancer Factor-2C, Muscle Muscle Enhancer Factor 2C Myocyte-Specific Enhancer-Binding Factor 2C Myocyte Specific Enhancer Binding Factor 2C Myocyte Enhancer Factor 2C Myocyte-Specific Enhancer Factor 2C Myocyte Specific Enhancer Factor 2C MEF2C Protein Muscle-Specific Enhancer Factor-2C Enhancer Factor-2C, Muscle-Specific Muscle Specific Enhancer Factor 2C

Below are MeSH descriptors whose meaning is more general than "MEF2 Transcription Factors".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Contractile Proteins [D12.776.210]
Muscle Proteins [D12.776.210.500]
Myogenic Regulatory Factors [D12.776.210.500.570]
MEF2 Transcription Factors [D12.776.210.500.570.294]
DNA-Binding Proteins [D12.776.260]
Basic Helix-Loop-Helix Transcription Factors [D12.776.260.103]
Myogenic Regulatory Factors [D12.776.260.103.750]
MEF2 Transcription Factors [D12.776.260.103.750.294]
Homeodomain Proteins [D12.776.260.400]
MADS Domain Proteins [D12.776.260.400.249]
MEF2 Transcription Factors [D12.776.260.400.249.624]
Transcription Factors [D12.776.930]
Basic Helix-Loop-Helix Transcription Factors [D12.776.930.125]
Myogenic Regulatory Factors [D12.776.930.125.750]
MEF2 Transcription Factors [D12.776.930.125.750.294]
MADS Domain Proteins [D12.776.930.397]
MEF2 Transcription Factors [D12.776.930.397.700]

Below are MeSH descriptors whose meaning is related to "MEF2 Transcription Factors".

Below are MeSH descriptors whose meaning is more specific than "MEF2 Transcription Factors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "MEF2 Transcription Factors" by people in this website by year, and whether "MEF2 Transcription Factors" was a major or minor topic of these publications.

Bar chart showing 9 publications over 8 distinct years, with a maximum of 2 publications in 2006

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
2002	1	1
2004	1	1
2005	1	1
2006	2	2
2009	1	1
2014	1	1
2016	1	1
2020	1	1

Below are the most recent publications written about "MEF2 Transcription Factors" by people in Profiles.

Judge SM, Deyhle MR, Neyroud D, Nosacka RL, D'Lugos AC, Cameron ME, Vohra RS, Smuder AJ, Roberts BM, Callaway CS, Underwood PW, Chrzanowski SM, Batra A, Murphy ME, Heaven JD, Walter GA, Trevino JG, Judge AR. MEF2c-Dependent Downregulation of Myocilin Mediates Cancer-Induced Muscle Wasting and Associates with Cachexia in Patients with Cancer. Cancer Res. 2020 05 01; 80(9):1861-1874.

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Ataman B, Boulting GL, Harmin DA, Yang MG, Baker-Salisbury M, Yap EL, Malik AN, Mei K, Rubin AA, Spiegel I, Durresi E, Sharma N, Hu LS, Pletikos M, Griffith EC, Partlow JN, Stevens CR, Adli M, Chahrour M, Sestan N, Walsh CA, Berezovskii VK, Livingstone MS, Greenberg ME. Evolution of Osteocrin as an activity-regulated factor in the primate brain. Nature. 2016 11 10; 539(7628):242-247.

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Clark AL, Maruyama S, Sano S, Accorsi A, Girgenrath M, Walsh K, Naya FJ. miR-410 and miR-495 Are Dynamically Regulated in Diverse Cardiomyopathies and Their Inhibition Attenuates Pathological Hypertrophy. PLoS One. 2016; 11(3):e0151515.

View in: PubMed
Obri A, Makinistoglu MP, Zhang H, Karsenty G. HDAC4 integrates PTH and sympathetic signaling in osteoblasts. J Cell Biol. 2014 Jun 23; 205(6):771-80.

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McCalmon SA, Desjardins DM, Ahmad S, Davidoff KS, Snyder CM, Sato K, Ohashi K, Kielbasa OM, Mathew M, Ewen EP, Walsh K, Gavras H, Naya FJ. Modulation of angiotensin II-mediated cardiac remodeling by the MEF2A target gene Xirp2. Circ Res. 2010 Mar 19; 106(5):952-60.

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Gerstein RM. Deciding the decider: Mef2c in hematopoiesis. Nat Immunol. 2009 Mar; 10(3):235-6.

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Schnabel R, Dupuis J, Larson MG, Lunetta KL, Robins SJ, Zhu Y, Rong J, Yin X, Stirnadel HA, Nelson JJ, Wilson PW, Keaney JF, Vasan RS, Benjamin EJ. Clinical and genetic factors associated with lipoprotein-associated phospholipase A2 in the Framingham Heart Study. Atherosclerosis. 2009 Jun; 204(2):601-7.

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Flavell SW, Cowan CW, Kim TK, Greer PL, Lin Y, Paradis S, Griffith EC, Hu LS, Chen C, Greenberg ME. Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number. Science. 2006 Feb 17; 311(5763):1008-12.

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Ohkawa Y, Marfella CG, Imbalzano AN. Skeletal muscle specification by myogenin and Mef2D via the SWI/SNF ATPase Brg1. EMBO J. 2006 Feb 08; 25(3):490-501.

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de la Serna IL, Ohkawa Y, Berkes CA, Bergstrom DA, Dacwag CS, Tapscott SJ, Imbalzano AN. MyoD targets chromatin remodeling complexes to the myogenin locus prior to forming a stable DNA-bound complex. Mol Cell Biol. 2005 May; 25(10):3997-4009.

View in: PubMed

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