"Myosins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A diverse superfamily of proteins that function as translocating proteins. They share the common characteristics of being able to bind ACTINS and hydrolyze MgATP. Myosins generally consist of heavy chains which are involved in locomotion, and light chains which are involved in regulation. Within the structure of myosin heavy chain are three domains: the head, the neck and the tail. The head region of the heavy chain contains the actin binding domain and MgATPase domain which provides energy for locomotion. The neck region is involved in binding the light-chains. The tail region provides the anchoring point that maintains the position of the heavy chain. The superfamily of myosins is organized into structural classes based upon the type and arrangement of the subunits they contain.
| Descriptor ID |
D009218
|
| MeSH Number(s) |
D05.750.078.730.475 D08.811.277.040.025.193.750 D12.776.210.500.600 D12.776.220.525.475
|
| Concept/Terms |
Myosins- Myosins
- Adenosine Triphosphatase, Myosin
- Myosin Adenosine Triphosphatase
- Adenosinetriphosphatase, Myosin
- Myosin ATPase
- ATPase, Myosin
- Myosin
- Myosin Adenosinetriphosphatase
- Actin-Activated ATPase
- Actin Activated ATPase
- ATPase, Actin-Activated
- ATPase, Actin Activated
|
Below are MeSH descriptors whose meaning is more general than "Myosins".
Below are MeSH descriptors whose meaning is more specific than "Myosins".
This graph shows the total number of publications written about "Myosins" by people in this website by year, and whether "Myosins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1997 | 1 | 1 | 2 |
| 1998 | 1 | 0 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 4 | 1 | 5 |
| 2002 | 3 | 0 | 3 |
| 2003 | 1 | 3 | 4 |
| 2004 | 3 | 1 | 4 |
| 2005 | 2 | 0 | 2 |
| 2006 | 3 | 1 | 4 |
| 2008 | 7 | 1 | 8 |
| 2009 | 1 | 3 | 4 |
| 2011 | 2 | 1 | 3 |
| 2012 | 2 | 1 | 3 |
| 2013 | 3 | 1 | 4 |
| 2014 | 1 | 2 | 3 |
| 2015 | 4 | 2 | 6 |
| 2016 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 2 | 0 | 2 |
| 2019 | 4 | 2 | 6 |
| 2020 | 4 | 0 | 4 |
| 2021 | 4 | 1 | 5 |
| 2022 | 3 | 1 | 4 |
| 2023 | 1 | 0 | 1 |
| 2024 | 0 | 3 | 3 |
| 2025 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "Myosins" by people in Profiles.
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Marang CP, Petersen DJ, Scott BD, Walcott S, Debold EP. Characterizing the concentration and load dependence of phosphate binding to rabbit fast skeletal actomyosin. Proc Natl Acad Sci U S A. 2025 May 20; 122(20):e2504758122.
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Debold EP, Westerblad H. New insights into the cellular and molecular mechanisms of skeletal muscle fatigue: the Marion J. Siegman Award Lectureships. Am J Physiol Cell Physiol. 2024 Oct 01; 327(4):C946-C958.
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Kinnear C, Said A, Meng G, Zhao Y, Wang EY, Rafatian N, Parmar N, Wei W, Billia F, Simmons CA, Radisic M, Ellis J, Mital S. Myosin inhibitor reverses hypertrophic cardiomyopathy in genotypically diverse pediatric iPSC-cardiomyocytes to mirror variant correction. Cell Rep Med. 2024 May 21; 5(5):101520.
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Liu S, Marang C, Woodward M, Joumaa V, Leonard T, Scott B, Debold E, Herzog W, Walcott S. Modeling thick filament activation suggests a molecular basis for force depression. Biophys J. 2024 03 05; 123(5):555-571.
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Marang C, Scott B, Chambers J, Gunther LK, Yengo CM, Debold EP. A mutation in switch I alters the load-dependent kinetics of myosin Va. Nat Commun. 2023 05 30; 14(1):3137.
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Rasicci DV, Tiwari P, Bodt SML, Desetty R, Sadler FR, Sivaramakrishnan S, Craig R, Yengo CM. Dilated cardiomyopathy mutation E525K in human beta-cardiac myosin stabilizes the interacting-heads motif and super-relaxed state of myosin. Elife. 2022 11 24; 11.
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Padr?n R, Dutta D, Craig R. Variants of the myosin interacting-heads motif. J Gen Physiol. 2023 01 02; 155(1).
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Debold EP. Recent insights into the relative timing of myosin's powerstroke and release of phosphate. Cytoskeleton (Hoboken). 2021 09; 78(9):448-458.
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Koubassova NA, Tsaturyan AK, Bershitsky SY, Ferenczi MA, Padr?n R, Craig R. Interacting-heads motif explains the X-ray diffraction pattern of relaxed vertebrate skeletal muscle. Biophys J. 2022 04 19; 121(8):1354-1366.
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Craig R, Padr?n R. Structural basis of the super- and hyper-relaxed states of myosin II. J Gen Physiol. 2022 01 03; 154(1).