 Tropomyosin
"Tropomyosin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein found in the thin filaments of muscle fibers. It inhibits contraction of the muscle unless its position is modified by TROPONIN.
| Descriptor ID |
D014335
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| MeSH Number(s) |
D05.750.078.730.800 D12.776.210.500.895 D12.776.220.525.800
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Tropomyosin".
Below are MeSH descriptors whose meaning is more specific than "Tropomyosin".
This graph shows the total number of publications written about "Tropomyosin" by people in this website by year, and whether "Tropomyosin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1980 | 0 | 1 | 1 | | 1994 | 1 | 0 | 1 | | 1995 | 1 | 0 | 1 | | 1999 | 1 | 1 | 2 | | 2000 | 1 | 0 | 1 | | 2001 | 1 | 0 | 1 | | 2002 | 0 | 1 | 1 | | 2003 | 1 | 0 | 1 | | 2005 | 1 | 1 | 2 | | 2006 | 0 | 2 | 2 | | 2008 | 3 | 0 | 3 | | 2009 | 3 | 0 | 3 | | 2011 | 1 | 1 | 2 | | 2012 | 0 | 2 | 2 | | 2014 | 1 | 1 | 2 | | 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "Tropomyosin" by people in Profiles.
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Mun JY, Kensler RW, Harris SP, Craig R. The cMyBP-C HCM variant L348P enhances thin filament activation through an increased shift in tropomyosin position. J Mol Cell Cardiol. 2016 Feb; 91:141-7.
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Yang S, Barbu-Tudoran L, Orzechowski M, Craig R, Trinick J, White H, Lehman W. Three-dimensional organization of troponin on cardiac muscle thin filaments in the relaxed state. Biophys J. 2014 Feb 18; 106(4):855-64.
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Mun JY, Previs MJ, Yu HY, Gulick J, Tobacman LS, Beck Previs S, Robbins J, Warshaw DM, Craig R. Myosin-binding protein C displaces tropomyosin to activate cardiac thin filaments and governs their speed by an independent mechanism. Proc Natl Acad Sci U S A. 2014 Feb 11; 111(6):2170-5.
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Debold EP, Longyear TJ, Turner MA. The effects of phosphate and acidosis on regulated thin-filament velocity in an in vitro motility assay. J Appl Physiol (1985). 2012 Nov; 113(9):1413-22.
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Debold EP. Recent insights into the molecular basis of muscular fatigue. Med Sci Sports Exerc. 2012 Aug; 44(8):1440-52.
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Mun JY, Gulick J, Robbins J, Woodhead J, Lehman W, Craig R. Electron microscopy and 3D reconstruction of F-actin decorated with cardiac myosin-binding protein C (cMyBP-C). J Mol Biol. 2011 Jul 8; 410(2):214-25.
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Li XE, Tobacman LS, Mun JY, Craig R, Fischer S, Lehman W. Tropomyosin position on F-actin revealed by EM reconstruction and computational chemistry. Biophys J. 2011 Feb 16; 100(4):1005-13.
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Galinska A, Hatch V, Craig R, Murphy AM, Van Eyk JE, Wang CL, Lehman W, Foster DB. The C terminus of cardiac troponin I stabilizes the Ca2+-activated state of tropomyosin on actin filaments. Circ Res. 2010 Mar 05; 106(4):705-11.
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Cammarato A, Craig R, Lehman W. Electron microscopy and three-dimensional reconstruction of native thin filaments reveal species-specific differences in regulatory strand densities. Biochem Biophys Res Commun. 2010 Jan 1; 391(1):193-7.
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Lehman W, Galinska-Rakoczy A, Hatch V, Tobacman LS, Craig R. Structural basis for the activation of muscle contraction by troponin and tropomyosin. J Mol Biol. 2009 May 15; 388(4):673-81.
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