Neurodegenerative Diseases

"Neurodegenerative Diseases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.

Descriptor ID	D019636
MeSH Number(s)	C10.574
Concept/Terms	Neurodegenerative Diseases Neurodegenerative Diseases Neurodegenerative Disease Degenerative Diseases, Neurologic Neurologic Degenerative Disease Degenerative Neurologic Diseases Degenerative Neurologic Disease Neurologic Disease, Degenerative Neurologic Diseases, Degenerative Nervous System Degenerative Diseases Neurodegenerative Disorders Neurodegenerative Disorder Neurologic Degenerative Conditions Degenerative Condition, Neurologic Degenerative Conditions, Neurologic Neurologic Degenerative Condition Neurologic Degenerative Diseases Degenerative Diseases, Nervous System Degenerative Neurologic Disorders Degenerative Neurologic Disorder Neurologic Disorder, Degenerative Neurologic Disorders, Degenerative Degenerative Diseases, Spinal Cord Degenerative Diseases, Spinal Cord Degenerative Diseases, Central Nervous System Degenerative Diseases, Central Nervous System

Below are MeSH descriptors whose meaning is more general than "Neurodegenerative Diseases".

Diseases [C]
Nervous System Diseases [C10]
Neurodegenerative Diseases [C10.574]

Below are MeSH descriptors whose meaning is related to "Neurodegenerative Diseases".

Below are MeSH descriptors whose meaning is more specific than "Neurodegenerative Diseases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Neurodegenerative Diseases" by people in this website by year, and whether "Neurodegenerative Diseases" was a major or minor topic of these publications.

Bar chart showing 118 publications over 24 distinct years, with a maximum of 13 publications in 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	0	1	1
2002	1	1	2
2003	3	0	3
2005	2	0	2
2006	2	0	2
2007	3	0	3
2009	4	0	4
2010	2	1	3
2011	2	3	5
2012	1	1	2
2013	1	0	1
2014	3	0	3
2015	1	2	3
2016	4	0	4
2017	7	3	10
2018	6	2	8
2019	3	2	5
2020	6	1	7
2021	9	4	13
2022	12	0	12
2023	8	1	9
2024	8	1	9
2025	6	0	6
2026	1	0	1

Below are the most recent publications written about "Neurodegenerative Diseases" by people in Profiles.

Sagarbarria I, Seo J, Smith AJ, Vazey EM, Tremblay KD, Mager J, Hardy JA. Optimized detection of caspase-6 activation in a murine inflammation model to inform neurodegenerative disease therapies. PLoS One. 2026; 21(6):e0351312.

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Sabbagh MN, Cummings JL, Ballard C, van der Flier WM, Heneka MT, Holst JJ, Knudsen LB, Salloway S, Tansey MG, Drucker DJ. Repurposing glucagon-like peptide-1 receptor agonists for the treatment of neurodegenerative disorders. Nat Aging. 2026 Jan; 6(1):56-67.

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Miao G, Fortier TM, Liu H, Schafer DP, Fitzgerald KA, Mao J, Baehrecke EH. Microglia promote inflammatory cell death upon neuronal mitochondrial impairment during neurodegeneration. Nat Struct Mol Biol. 2025 Oct; 32(10):2046-2059.

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Vear A, Heneka MT, Clemmensen C. Incretin-based therapeutics for the treatment of neurodegenerative diseases. Nat Metab. 2025 Apr; 7(4):679-696.

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Lonkar N, Latz E, McManus RM. Neuroinflammation and immunometabolism in neurodegenerative diseases. Curr Opin Neurol. 2025 Apr 01; 38(2):163-171.

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Elyaman W, Stern LJ, Jiang N, Dressman D, Bradley P, Klatzmann D, Bradshaw EM, Farber DL, Kent SC, Chizari S, Funk K, Devanand D, Thakur KT, Raj T, Dalahmah OA, Sarkis RA, Weiner HL, Shneider NA, Przedborski S. Exploring the role of T?cells in Alzheimer's and other neurodegenerative diseases: Emerging therapeutic insights from the T Cells in the Brain symposium. Alzheimers Dement. 2025 02; 21(2):e14548.

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van Zundert B, Montecino M. Epigenetics in Neurodegenerative Diseases. Subcell Biochem. 2025; 108:73-109.

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Lee S, Silverman N, Gao FB. Emerging roles of antimicrobial peptides in innate immunity, neuronal function, and neurodegeneration. Trends Neurosci. 2024 11; 47(11):949-961.

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Ahmad S, Imtiaz MA, Mishra A, Wang R, Herrera-Rivero M, Bis JC, Fornage M, Roshchupkin G, Hofer E, Logue M, Longstreth WT, Xia R, Bouteloup V, Mosley T, Launer LJ, Khalil M, Kuhle J, Rissman RA, Chene G, Dufouil C, Djouss? L, Lyons MJ, Mukamal KJ, Kremen WS, Franz CE, Schmidt R, Debette S, Breteler MMB, Berger K, Yang Q, Seshadri S, Aziz NA, Ghanbari M, Ikram MA. Genome-wide association study meta-analysis of neurofilament light (NfL) levels in blood reveals novel loci related to neurodegeneration. Commun Biol. 2024 09 09; 7(1):1103.

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Bonhenry D, Charnley M, Gon?alves J, Hammarstr?m P, Heneka MT, Itzhaki R, Lambert JC, Mannan M, Baig AM, Middeldorp J, Nystr?m S, Reynolds NP, Stefanatou M, Berryman JT. SARS-CoV-2 infection as a cause of neurodegeneration. Lancet Neurol. 2024 06; 23(6):562-563.

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