Ribonucleoprotein, U4-U6 Small Nuclear
"Ribonucleoprotein, U4-U6 Small Nuclear" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U4-U6 snRNP along with the U5 snRNP preassemble into a single 25S particle that binds to the U1 and U2 snRNPs and the substrate to form mature SPLICEOSOMES. There is also evidence for the existence of individual U4 or U6 snRNPs in addition to their organization as a U4-U6 snRNP.
| Descriptor ID |
D017414
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| MeSH Number(s) |
D12.776.157.725.500.875.615 D12.776.664.962.500.875.615
|
| Concept/Terms |
Ribonucleoprotein, U4-U6 Small Nuclear- Ribonucleoprotein, U4-U6 Small Nuclear
- Ribonucleoprotein, U4 U6 Small Nuclear
- U4-U6 Small Nuclear Ribonucleoproteins
- U4 U6 Small Nuclear Ribonucleoproteins
- Small Nuclear Ribonucleoproteins, U4-U6
- Small Nuclear Ribonucleoproteins, U4 U6
- U4-U6 snRNP
- Ribonucleoproteins, Small, U4-U6
U6 snRNP- U6 snRNP
- U6 Small Nuclear Ribonucleoproteins
- Ribonucleoproteins, U6 Small Nuclear
- Small Nuclear Ribonucleoproteins, U6
U4 snRNP- U4 snRNP
- U4 Small Nuclear Ribonucleoproteins
- Ribonucleoproteins, U4 Small Nuclear
- Small Nuclear Ribonucleoproteins, U4
|
Below are MeSH descriptors whose meaning is more general than "Ribonucleoprotein, U4-U6 Small Nuclear".
Below are MeSH descriptors whose meaning is more specific than "Ribonucleoprotein, U4-U6 Small Nuclear".
This graph shows the total number of publications written about "Ribonucleoprotein, U4-U6 Small Nuclear" by people in this website by year, and whether "Ribonucleoprotein, U4-U6 Small Nuclear" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2011 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ribonucleoprotein, U4-U6 Small Nuclear" by people in Profiles.
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Hoskins AA, Rodgers ML, Friedman LJ, Gelles J, Moore MJ. Single molecule analysis reveals reversible and irreversible steps during spliceosome activation. Elife. 2016 05 31; 5.
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Long SW, Ooi JY, Yau PM, Jones PL. A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing. Biosci Rep. 2011 Oct; 31(5):333-43.
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Hoskins AA, Friedman LJ, Gallagher SS, Crawford DJ, Anderson EG, Wombacher R, Ramirez N, Cornish VW, Gelles J, Moore MJ. Ordered and dynamic assembly of single spliceosomes. Science. 2011 Mar 11; 331(6022):1289-95.
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O'Brien K, Matlin AJ, Lowell AM, Moore MJ. The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing. J Biol Chem. 2008 Nov 28; 283(48):33147-54.
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Shen H, Zheng X, Shen J, Zhang L, Zhao R, Green MR. Distinct activities of the DExD/H-box splicing factor hUAP56 facilitate stepwise assembly of the spliceosome. Genes Dev. 2008 Jul 01; 22(13):1796-803.
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Bellare P, Small EC, Huang X, Wohlschlegel JA, Staley JP, Sontheimer EJ. A role for ubiquitin in the spliceosome assembly pathway. Nat Struct Mol Biol. 2008 May; 15(5):444-51.
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Bellare P, Kutach AK, Rines AK, Guthrie C, Sontheimer EJ. Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p. RNA. 2006 Feb; 12(2):292-302.
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Jurica MS, Sousa D, Moore MJ, Grigorieff N. Three-dimensional structure of C complex spliceosomes by electron microscopy. Nat Struct Mol Biol. 2004 Mar; 11(3):265-9.