Myostatin

"Myostatin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A growth differentiation factor that is a potent inhibitor of SKELETAL MUSCLE growth. It may play a role in the regulation of MYOGENESIS and in muscle maintenance during adulthood.

Descriptor ID	D055435
MeSH Number(s)	D12.644.276.954.300.925 D12.776.467.942.300.925 D23.529.942.300.925
Concept/Terms	Myostatin Myostatin Growth Differentiation Factor 8 GDF-8

Below are MeSH descriptors whose meaning is more general than "Myostatin".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
TGF-beta Superfamily Proteins [D12.644.276.954]
Growth Differentiation Factors [D12.644.276.954.300]
Myostatin [D12.644.276.954.300.925]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
TGF-beta Superfamily Proteins [D12.776.467.942]
Growth Differentiation Factors [D12.776.467.942.300]
Myostatin [D12.776.467.942.300.925]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
TGF-beta Superfamily Proteins [D23.529.942]
Growth Differentiation Factors [D23.529.942.300]
Myostatin [D23.529.942.300.925]

Below are MeSH descriptors whose meaning is related to "Myostatin".

Below are MeSH descriptors whose meaning is more specific than "Myostatin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Myostatin" by people in this website by year, and whether "Myostatin" was a major or minor topic of these publications.

Bar chart showing 10 publications over 8 distinct years, with a maximum of 2 publications in 2011 and 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2006	0	1	1
2008	0	1	1
2009	0	1	1
2010	0	1	1
2011	2	0	2
2012	0	1	1
2015	1	0	1
2020	2	0	2

Below are the most recent publications written about "Myostatin" by people in Profiles.

Biscans A, Caiazzi J, McHugh N, Hariharan V, Muhuri M, Khvorova A. Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles. Mol Ther. 2021 04 07; 29(4):1382-1394.

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Walker RG, Barrandon O, Poggioli T, Dagdeviren S, Carroll SH, Mills MJ, Mendello KR, Gomez Y, Loffredo FS, Pancoast JR, Macias-Trevino C, Marts C, LeClair KB, Noh HL, Kim T, Banks AS, Kim JK, Cohen DE, Wagers AJ, Melton DA, Lee RT. Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice. Sci Rep. 2020 03 12; 10(1):4561.

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Guo W, Miller AD, Pencina K, Wong S, Lee A, Yee M, Toraldo G, Jasuja R, Bhasin S. Joint dysfunction and functional decline in middle age myostatin null mice. Bone. 2016 Feb; 83:141-148.

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Lee SJ, Huynh TV, Lee YS, Sebald SM, Wilcox-Adelman SA, Iwamori N, Lepper C, Matzuk MM, Fan CM. Role of satellite cells versus myofibers in muscle hypertrophy induced by inhibition of the myostatin/activin signaling pathway. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):E2353-60.

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Bonomi L, Brown M, Ungerleider N, Muse M, Matzuk MM, Schneyer A. Activin B regulates islet composition and islet mass but not whole body glucose homeostasis or insulin sensitivity. Am J Physiol Endocrinol Metab. 2012 Sep 01; 303(5):E587-96.

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Brown ML, Kimura F, Bonomi LM, Ungerleider NA, Schneyer AL. Differential synthesis and action of TGF? superfamily ligands in mouse and rat islets. Islets. 2011 Nov-Dec; 3(6):367-75.

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Rahimov F, King OD, Warsing LC, Powell RE, Emerson CP, Kunkel LM, Wagner KR. Gene expression profiling of skeletal muscles treated with a soluble activin type IIB receptor. Physiol Genomics. 2011 Apr 27; 43(8):398-407.

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Dasarathy S, McCullough AJ, Muc S, Schneyer A, Bennett CD, Dodig M, Kalhan SC. Sarcopenia associated with portosystemic shunting is reversed by follistatin. J Hepatol. 2011 May; 54(5):915-21.

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Brown RH. Medicine. A reinnervating microRNA. Science. 2009 Dec 11; 326(5959):1494-5.

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Schneyer AL, Sidis Y, Gulati A, Sun JL, Keutmann H, Krasney PA. Differential antagonism of activin, myostatin and growth and differentiation factor 11 by wild-type and mutant follistatin. Endocrinology. 2008 Sep; 149(9):4589-95.

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