 Antigens, CD86
"Antigens, CD86" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
| Descriptor ID |
D051940
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| MeSH Number(s) |
D12.776.467.150.200 D12.776.543.095.200 D23.050.301.264.035.276.200 D23.050.301.285.200 D23.101.100.110.276.200 D23.529.168.200
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| Concept/Terms |
Antigens, CD86- Antigens, CD86
- B7-2 Antigen
- B7 2 Antigen
- Early T Cell Costimulatory Molecule 1
- B70 Costimulatory Molecule
- Costimulatory Molecule, B70
- CD86 Antigen
- Antigen, CD86
- CD86 Antigens
- Antigen, B7-2
- Antigen, B7 2
- B7-2 Costimulatory Molecule
- Costimulatory Molecule, B7-2
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Below are MeSH descriptors whose meaning is more general than "Antigens, CD86".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Intercellular Signaling Peptides and Proteins [D12.776.467]
- B7 Antigens [D12.776.467.150]
- Antigens, CD86 [D12.776.467.150.200]
- Membrane Proteins [D12.776.543]
- B7 Antigens [D12.776.543.095]
- Antigens, CD86 [D12.776.543.095.200]
- Biological Factors [D23]
- Antigens [D23.050]
- Antigens, Surface [D23.050.301]
- Antigens, Differentiation [D23.050.301.264]
- Antigens, CD [D23.050.301.264.035]
- B7 Antigens [D23.050.301.264.035.276]
- Antigens, CD86 [D23.050.301.264.035.276.200]
- B7 Antigens [D23.050.301.285]
- Antigens, CD86 [D23.050.301.285.200]
- Biological Markers [D23.101]
- Antigens, Differentiation [D23.101.100]
- Antigens, CD [D23.101.100.110]
- B7 Antigens [D23.101.100.110.276]
- Antigens, CD86 [D23.101.100.110.276.200]
- Intercellular Signaling Peptides and Proteins [D23.529]
- B7 Antigens [D23.529.168]
- Antigens, CD86 [D23.529.168.200]
Below are MeSH descriptors whose meaning is more specific than "Antigens, CD86".
This graph shows the total number of publications written about "Antigens, CD86" by people in this website by year, and whether "Antigens, CD86" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 | | 1997 | 0 | 2 | 2 | | 1998 | 0 | 4 | 4 | | 2000 | 0 | 3 | 3 | | 2001 | 0 | 3 | 3 | | 2002 | 0 | 4 | 4 | | 2003 | 0 | 1 | 1 | | 2004 | 0 | 2 | 2 | | 2006 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Antigens, CD86" by people in Profiles.
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Wang Q, McLoughlin RM, Cobb BA, Charrel-Dennis M, Zaleski KJ, Golenbock D, Tzianabos AO, Kasper DL. A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2. J Exp Med. 2006 Dec 25; 203(13):2853-63.
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Vivarelli MS, McDonald D, Miller M, Cusson N, Kelliher M, Geha RS. RIP links TLR4 to Akt and is essential for cell survival in response to LPS stimulation. J Exp Med. 2004 Aug 2; 200(3):399-404.
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Zhu X, Coleman RA, Alber C, Ballas ZK, Waldschmidt TJ, Ray NB, Krieg AM, Cook RT. Chronic ethanol ingestion by mice increases expression of CD80 and CD86 by activated macrophages. Alcohol. 2004 Feb; 32(2):91-100.
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Pearson T, Markees TG, Serreze DV, Pierce MA, Marron MP, Wicker LS, Peterson LB, Shultz LD, Mordes JP, Rossini AA, Greiner DL. Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice. J Immunol. 2003 Jul 1; 171(1):185-95.
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Montgomery SP, Xu H, Tadaki DK, Celniker A, Burkly LC, Berning JD, Cruzata F, Elster EA, Gray G, Kampen RL, Swanson SJ, Harlan DM, Kirk AD. Combination induction therapy with monoclonal antibodies specific for CD80, CD86, and CD154 in nonhuman primate renal transplantation. Transplantation. 2002 Nov 27; 74(10):1365-9.
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Yen MH, Lepak N, Swain SL. Induction of CD4 T cell changes in murine AIDS is dependent on costimulation and involves a dysregulation of homeostasis. J Immunol. 2002 Jul 15; 169(2):722-31.
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Viglietta V, Kent SC, Orban T, Hafler DA. GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes. J Clin Invest. 2002 Apr; 109(7):895-903.
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Massari P, Henneke P, Ho Y, Latz E, Golenbock DT, Wetzler LM. Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent. J Immunol. 2002 Feb 15; 168(4):1533-7.
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Szabo G, Mandrekar P, Dolganiuc A, Catalano D, Kodys K. Reduced alloreactive T-cell activation after alcohol intake is due to impaired monocyte accessory cell function and correlates with elevated IL-10, IL-13, and decreased IFNgamma levels. Alcohol Clin Exp Res. 2001 Dec; 25(12):1766-72.
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Kirk AD, Tadaki DK, Celniker A, Batty DS, Berning JD, Colonna JO, Cruzata F, Elster EA, Gray GS, Kampen RL, Patterson NB, Szklut P, Swanson J, Xu H, Harlan DM. Induction therapy with monoclonal antibodies specific for CD80 and CD86 delays the onset of acute renal allograft rejection in non-human primates. Transplantation. 2001 Aug 15; 72(3):377-84.
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