Lymphocyte Specific Protein Tyrosine Kinase p56(lck)

"Lymphocyte Specific Protein Tyrosine Kinase p56(lck)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

This enzyme is a lymphoid-specific src family tyrosine kinase that is critical for T-cell development and activation. Lck is associated with the cytoplasmic domains of CD4, CD8 and the beta-chain of the IL-2 receptor, and is thought to be involved in the earliest steps of TCR-mediated T-cell activation.

Descriptor ID	D019860
MeSH Number(s)	D08.811.913.696.620.682.725.800.315 D12.776.624.664.700.128
Concept/Terms	Lymphocyte Specific Protein Tyrosine Kinase p56(lck) Lymphocyte Specific Protein Tyrosine Kinase p56(lck) p56 lck Proto-Oncogene Protein c-lck Protein c-lck, Proto-Oncogene Proto Oncogene Protein c lck c-lck, Proto-Oncogene Protein Proto-Oncogene Protein lck Protein lck, Proto-Oncogene Proto Oncogene Protein lck lck, Proto-Oncogene Protein lck Kinase Kinase, lck Protein Tyrosine Kinase p56(lck)

Below are MeSH descriptors whose meaning is more general than "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
src-Family Kinases [D08.811.913.696.620.682.725.800]
Lymphocyte Specific Protein Tyrosine Kinase p56(lck) [D08.811.913.696.620.682.725.800.315]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Neoplasm Proteins [D12.776.624]
Oncogene Proteins [D12.776.624.664]
Proto-Oncogene Proteins [D12.776.624.664.700]
Lymphocyte Specific Protein Tyrosine Kinase p56(lck) [D12.776.624.664.700.128]

Below are MeSH descriptors whose meaning is related to "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)".

Below are MeSH descriptors whose meaning is more specific than "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)" by people in this website by year, and whether "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)" was a major or minor topic of these publications.

Bar chart showing 7 publications over 7 distinct years, with a maximum of 1 publications in 1995 and 1996 and 2002 and 2005 and 2013 and 2014 and 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
1996	0	1	1
2002	1	0	1
2005	0	1	1
2013	0	1	1
2014	0	1	1
2022	1	0	1

Below are the most recent publications written about "Lymphocyte Specific Protein Tyrosine Kinase p56(lck)" by people in Profiles.

Laukkanen S, Veloso A, Yan C, Oksa L, Alpert EJ, Do D, Hyv?rinen N, McCarthy K, Adhikari A, Yang Q, Iyer S, Garcia SP, Pello A, Ruokoranta T, Moisio S, Adhikari S, Yoder JA, Gallagher K, Whelton L, Allen JR, Jin AH, Loontiens S, Hein?niemi M, Kelliher M, Heckman CA, Lohi O, Langenau DM. Therapeutic targeting of LCK tyrosine kinase and mTOR signaling in T-cell acute lymphoblastic leukemia. Blood. 2022 10 27; 140(17):1891-1906.

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Stepanek O, Prabhakar AS, Osswald C, King CG, Bulek A, Naeher D, Beaufils-Hugot M, Abanto ML, Galati V, Hausmann B, Lang R, Cole DK, Huseby ES, Sewell AK, Chakraborty AK, Palmer E. Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance. Cell. 2014 Oct 09; 159(2):333-45.

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Clayton KL, Haaland MS, Douglas-Vail MB, Mujib S, Chew GM, Ndhlovu LC, Ostrowski MA. T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases. J Immunol. 2014 Jan 15; 192(2):782-91.

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Liu Y, Johnson SM, Fedoriw Y, Rogers AB, Yuan H, Krishnamurthy J, Sharpless NE. Expression of p16(INK4a) prevents cancer and promotes aging in lymphocytes. Blood. 2011 Mar 24; 117(12):3257-67.

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Torres E, Rosen MK. Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP. J Biol Chem. 2006 Feb 10; 281(6):3513-20.

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Waegell W, Babineau M, Hart M, Dixon K, McRae B, Wallace C, Leach M, Ratnofsky S, Belanger A, Hirst G, Rossini A, Appel M, Mordes J, Greiner D, Banerjee S. A420983, a novel, small molecule inhibitor of LCK prevents allograft rejection. Transplant Proc. 2002 Aug; 34(5):1411-7.

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Duboise SM, Lee H, Guo J, Choi JK, Czajak S, Simon M, Desrosiers RC, Jung JU. Mutation of the Lck-binding motif of Tip enhances lymphoid cell activation by herpesvirus saimiri. J Virol. 1998 Apr; 72(4):2607-14.

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Solomon KR, Mallory MA, Hanify KA, Finberg RW. The nature of membrane anchorage determines kinase association and detergent solubility of CD4. Biochem Biophys Res Commun. 1998 Jan 14; 242(2):423-8.

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Hartley D, Corvera S. Formation of c-Cbl.phosphatidylinositol 3-kinase complexes on lymphocyte membranes by a p56lck-independent mechanism. J Biol Chem. 1996 Sep 06; 271(36):21939-43.

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Jung JU, Lang SM, Jun T, Roberts TM, Veillette A, Desrosiers RC. Downregulation of Lck-mediated signal transduction by tip of herpesvirus saimiri. J Virol. 1995 Dec; 69(12):7814-22.

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