Mannose-Binding Protein-Associated Serine Proteases
"Mannose-Binding Protein-Associated Serine Proteases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Serum serine proteases which participate in COMPLEMENT ACTIVATION. They are activated when complexed with the MANNOSE-BINDING LECTIN, therefore also known as Mannose-binding protein-Associated Serine Proteases (MASPs). They cleave COMPLEMENT C4 and COMPLEMENT C2 to form C4b2a, the CLASSICAL PATHWAY C3 CONVERTASE.
| Descriptor ID |
D050606
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| MeSH Number(s) |
D08.811.277.656.300.760.501 D08.811.277.656.959.350.501 D12.776.124.486.274.045.387.875
|
| Concept/Terms |
Mannose-Binding Protein-Associated Serine Proteases- Mannose-Binding Protein-Associated Serine Proteases
- Mannose-Binding Protein-Associated Serine Protease
- Mannose Binding Protein Associated Serine Protease
- MBP-Associated Serine Protease
- MBP Associated Serine Protease
- Serine Protease, MBP-Associated
- MASPs
- Mannan-Binding Lectin Serine Proteases
- Mannan Binding Lectin Serine Proteases
- MBL-Associated Serine Proteases
- MBL Associated Serine Proteases
- Serine Proteases, MBL-Associated
- MASP Proteases
- Proteases, MASP
MASP-Related Protein- MASP-Related Protein
- MASP Related Protein
- Protein, MASP-Related
- MBP-Associated Serine Protease-Related Protein
- MBP Associated Serine Protease Related Protein
|
Below are MeSH descriptors whose meaning is more general than "Mannose-Binding Protein-Associated Serine Proteases".
Below are MeSH descriptors whose meaning is more specific than "Mannose-Binding Protein-Associated Serine Proteases".
This graph shows the total number of publications written about "Mannose-Binding Protein-Associated Serine Proteases" by people in this website by year, and whether "Mannose-Binding Protein-Associated Serine Proteases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 0 | 1 |
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Below are the most recent publications written about "Mannose-Binding Protein-Associated Serine Proteases" by people in Profiles.
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Rooryck C, Diaz-Font A, Osborn DP, Chabchoub E, Hernandez-Hernandez V, Shamseldin H, Kenny J, Waters A, Jenkins D, Kaissi AA, Leal GF, Dallapiccola B, Carnevale F, Bitner-Glindzicz M, Lees M, Hennekam R, Stanier P, Burns AJ, Peeters H, Alkuraya FS, Beales PL. Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome. Nat Genet. 2011 Mar; 43(3):197-203.