Oligonucleotides, Antisense

"Oligonucleotides, Antisense" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Short fragments of DNA or RNA that are used to alter the function of target RNAs or DNAs to which they hybridize.

Descriptor ID	D016376
MeSH Number(s)	D13.150.480 D13.444.600.150.640 D13.695.578.424.480 D27.720.470.530.600.150.640
Concept/Terms	Oligonucleotides, Antisense Oligonucleotides, Antisense Antisense Oligonucleotides Anti-Sense Oligonucleotides Anti Sense Oligonucleotides Oligonucleotides, Anti-Sense

Below are MeSH descriptors whose meaning is more general than "Oligonucleotides, Antisense".

Chemicals and Drugs [D]
Nucleic Acids, Nucleotides, and Nucleosides [D13]
Antisense Elements (Genetics) [D13.150]
Oligonucleotides, Antisense [D13.150.480]
Nucleic Acids [D13.444]
Nucleic Acid Probes [D13.444.600]
Antisense Elements (Genetics) [D13.444.600.150]
Oligonucleotides, Antisense [D13.444.600.150.640]
Nucleotides [D13.695]
Polynucleotides [D13.695.578]
Oligonucleotides [D13.695.578.424]
Oligonucleotides, Antisense [D13.695.578.424.480]
Chemical Actions and Uses [D27]
Specialty Uses of Chemicals [D27.720]
Laboratory Chemicals [D27.720.470]
Molecular Probes [D27.720.470.530]
Nucleic Acid Probes [D27.720.470.530.600]
Antisense Elements (Genetics) [D27.720.470.530.600.150]
Oligonucleotides, Antisense [D27.720.470.530.600.150.640]

Below are MeSH descriptors whose meaning is related to "Oligonucleotides, Antisense".

Below are MeSH descriptors whose meaning is more specific than "Oligonucleotides, Antisense".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Oligonucleotides, Antisense" by people in this website by year, and whether "Oligonucleotides, Antisense" was a major or minor topic of these publications.

Bar chart showing 86 publications over 26 distinct years, with a maximum of 8 publications in 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	2	3	5
1995	2	1	3
1996	3	0	3
1998	0	2	2
2001	1	1	2
2002	3	2	5
2003	2	3	5
2004	0	3	3
2005	2	5	7
2006	1	2	3
2007	1	0	1
2008	1	0	1
2009	1	0	1
2010	1	1	2
2011	3	1	4
2012	1	2	3
2014	1	2	3
2015	1	2	3
2016	3	1	4
2017	1	1	2
2018	6	2	8
2019	1	1	2
2021	4	0	4
2022	5	1	6
2023	0	2	2
2024	2	0	2

Below are the most recent publications written about "Oligonucleotides, Antisense" by people in Profiles.

Susorov D, Echeverria D, Khvorova A, Korostelev AA. mRNA-specific readthrough of nonsense codons by antisense oligonucleotides (R-ASOs). Nucleic Acids Res. 2024 Aug 27; 52(15):8687-8701.

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Sarli SL, Fakih HH, Kelly K, Devi G, Rembetsy-Brown JM, McEachern HR, Ferguson CM, Echeverria D, Lee J, Sousa J, Sleiman HF, Khvorova A, Watts JK. Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo. Nucleic Acids Res. 2024 May 22; 52(9):4799-4817.

View in: PubMed
Engelbeen S, O'Reilly D, Van De Vijver D, Verhaart I, van Putten M, Hariharan V, Hassler M, Khvorova A, Damha MJ, Aartsma-Rus A. Challenges of Assessing Exon 53 Skipping of the Human DMD Transcript with Locked Nucleic Acid-Modified Antisense Oligonucleotides in a Mouse Model for Duchenne Muscular Dystrophy. Nucleic Acid Ther. 2023 12; 33(6):348-360.

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Shah S, Sharp KJ, Raju Ponny S, Lee J, Watts JK, Berry-Kravis E, Richter JD. Antisense oligonucleotide rescue of CGG expansion-dependent FMR1 mis-splicing in fragile X syndrome restores FMRP. Proc Natl Acad Sci U S A. 2023 07 04; 120(27):e2302534120.

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Goyenvalle A, Jimenez-Mallebrera C, van Roon W, Sewing S, Krieg AM, Arechavala-Gomeza V, Andersson P. Considerations in the Preclinical Assessment of the Safety of Antisense Oligonucleotides. Nucleic Acid Ther. 2023 01; 33(1):1-16.

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Aartsma-Rus A, Garanto A, van Roon-Mom W, McConnell EM, Suslovitch V, Yan WX, Watts JK, Yu TW. Consensus Guidelines for the Design and In Vitro Preclinical Efficacy Testing N-of-1 Exon Skipping Antisense Oligonucleotides. Nucleic Acid Ther. 2023 01; 33(1):17-25.

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Wang F, Calvo-Roitberg E, Rembetsy-Brown JM, Fang M, Sousa J, Kartje ZJ, Krishnamurthy PM, Lee J, Green MR, Pai AA, Watts JK. G-rich motifs within phosphorothioate-based antisense oligonucleotides (ASOs) drive activation of FXN expression through indirect effects. Nucleic Acids Res. 2022 12 09; 50(22):12657-12673.

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Meijboom KE, Brown RH. Approaches to Gene Modulation Therapy for ALS. Neurotherapeutics. 2022 07; 19(4):1159-1179.

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Shin M, Chan IL, Cao Y, Gruntman AM, Lee J, Sousa J, Rodr?guez TC, Echeverria D, Devi G, Debacker AJ, Moazami MP, Krishnamurthy PM, Rembetsy-Brown JM, Kelly K, Yukselen O, Donnard E, Parsons TJ, Khvorova A, Sontheimer EJ, Maehr R, Garber M, Watts JK. Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts. Nucleic Acids Res. 2022 08 26; 50(15):8418-8430.

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Khvorova A. Modulation of DNA transcription: The future of ASO therapeutics? Cell. 2022 06 09; 185(12):2011-2013.

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