Granulosa Cells

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"Granulosa Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Supporting cells for the developing female gamete in the OVARY. They are derived from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the OOCYTE in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the OVUM in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors (RECEPTORS, LH).

Descriptor ID	D006107
MeSH Number(s)	A05.360.319.114.630.535.200 A06.407.312.497.535.300 A11.382.812 A11.436.329
Concept/Terms	Granulosa Cells Granulosa Cells Cell, Granulosa Cells, Granulosa Granulosa Cell

Below are MeSH descriptors whose meaning is more general than "Granulosa Cells".

Anatomy [A]
Urogenital System [A05]
Genitalia [A05.360]
Genitalia, Female [A05.360.319]
Adnexa Uteri [A05.360.319.114]
Ovary [A05.360.319.114.630]
Ovarian Follicle [A05.360.319.114.630.535]
Granulosa Cells [A05.360.319.114.630.535.200]
Endocrine System [A06]
Endocrine Glands [A06.407]
Gonads [A06.407.312]
Ovary [A06.407.312.497]
Ovarian Follicle [A06.407.312.497.535]
Granulosa Cells [A06.407.312.497.535.300]
Cells [A11]
Endocrine Cells [A11.382]
Granulosa Cells [A11.382.812]
Epithelial Cells [A11.436]
Granulosa Cells [A11.436.329]

Below are MeSH descriptors whose meaning is related to "Granulosa Cells".

Below are MeSH descriptors whose meaning is more specific than "Granulosa Cells".

Granulosa Cells
Cumulus Cells

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Granulosa Cells" by people in this website by year, and whether "Granulosa Cells" was a major or minor topic of these publications.

Bar chart showing 16 publications over 9 distinct years, with a maximum of 6 publications in 1996

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
1996	4	2	6
1998	1	0	1
2000	2	0	2
2001	1	1	2
2007	0	1	1
2010	0	1	1
2017	0	1	1
2019	0	1	1

Below are the most recent publications written about "Granulosa Cells" by people in Profiles.

Wu Y, Wang Y, Liu Q, Zhu LJ, Gao H, Cui M, Liu J, Zhao P, Liu J, Chen L, Wang J, Zeng W, Woodruff TK, Zeng S. Conserved microRNA mediates heating tolerance in germ cells versus surrounding somatic cells. RNA Biol. 2019 10; 16(10):1494-1503.

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Kano M, Sosulski AE, Zhang L, Saatcioglu HD, Wang D, Nagykery N, Sabatini ME, Gao G, Donahoe PK, P?pin D. AMH/MIS as a contraceptive that protects the ovarian reserve during chemotherapy. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):E1688-E1697.

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Griffith GJ, Trask MC, Hiller J, Walentuk M, Pawlak JB, Tremblay KD, Mager J. Yin-yang1 is required in the mammalian oocyte for follicle expansion. Biol Reprod. 2011 Apr; 84(4):654-63.

View in: PubMed
Combelles CM, Holick EA, Paolella LJ, Walker DC, Wu Q. Profiling of superoxide dismutase isoenzymes in compartments of the developing bovine antral follicles. Reproduction. 2010 May; 139(5):871-81.

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Xia Y, Yu PB, Sidis Y, Beppu H, Bloch KD, Schneyer AL, Lin HY. Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. J Biol Chem. 2007 Jun 22; 282(25):18129-18140.

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Fujiwara T, Sidis Y, Welt C, Lambert-Messerlian G, Fox J, Taylor A, Schneyer A. Dynamics of inhibin subunit and follistatin mRNA during development of normal and polycystic ovary syndrome follicles. J Clin Endocrinol Metab. 2001 Sep; 86(9):4206-15.

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Welt CK, Schneyer AL. Differential regulation of inhibin B and inhibin a by follicle-stimulating hormone and local growth factors in human granulosa cells from small antral follicles. J Clin Endocrinol Metab. 2001 Jan; 86(1):330-6.

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Fujiwara T, Lambert-Messerlian G, Sidis Y, Leykin L, Isaacson K, Toth T, Schneyer A. Analysis of follicular fluid hormone concentrations and granulosa cell mRNA levels for the inhibin-activin-follistatin system: relation to oocyte and embryo characteristics. Fertil Steril. 2000 Aug; 74(2):348-55.

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Porter MB, Brumsted JR, Sites CK. Effect of prolactin on follicle-stimulating hormone receptor binding and progesterone production in cultured porcine granulosa cells. Fertil Steril. 2000 Jan; 73(1):99-105.

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Sidis Y, Fujiwara T, Leykin L, Isaacson K, Toth T, Schneyer AL. Characterization of inhibin/activin subunit, activin receptor, and follistatin messenger ribonucleic acid in human and mouse oocytes: evidence for activin's paracrine signaling from granulosa cells to oocytes. Biol Reprod. 1998 Oct; 59(4):807-12.

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