Granulosa Cells

"Granulosa Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Supporting cells for the developing female gamete in the OVARY. They are derived from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the OOCYTE in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the OVUM in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors (RECEPTORS, LH).

Descriptor ID	D006107
MeSH Number(s)	A05.360.319.114.630.535.200 A06.407.312.497.535.300 A11.382.812 A11.436.329
Concept/Terms	Granulosa Cells Granulosa Cells Cell, Granulosa Cells, Granulosa Granulosa Cell

Below are MeSH descriptors whose meaning is more general than "Granulosa Cells".

Anatomy [A]
Urogenital System [A05]
Genitalia [A05.360]
Genitalia, Female [A05.360.319]
Adnexa Uteri [A05.360.319.114]
Ovary [A05.360.319.114.630]
Ovarian Follicle [A05.360.319.114.630.535]
Granulosa Cells [A05.360.319.114.630.535.200]
Endocrine System [A06]
Endocrine Glands [A06.407]
Gonads [A06.407.312]
Ovary [A06.407.312.497]
Ovarian Follicle [A06.407.312.497.535]
Granulosa Cells [A06.407.312.497.535.300]
Cells [A11]
Endocrine Cells [A11.382]
Granulosa Cells [A11.382.812]
Epithelial Cells [A11.436]
Granulosa Cells [A11.436.329]

Below are MeSH descriptors whose meaning is related to "Granulosa Cells".

Below are MeSH descriptors whose meaning is more specific than "Granulosa Cells".

Granulosa Cells
Cumulus Cells

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Granulosa Cells" by people in this website by year, and whether "Granulosa Cells" was a major or minor topic of these publications.

Bar chart showing 16 publications over 11 distinct years, with a maximum of 4 publications in 1996

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	2	2	4
1998	1	0	1
2000	1	0	1
2001	1	1	2
2005	0	1	1
2007	0	1	1
2010	0	1	1
2015	1	0	1
2017	1	1	2
2019	0	1	1
2025	0	1	1

Below are the most recent publications written about "Granulosa Cells" by people in Profiles.

B?rub? M, Gusscott S, Mao J, Zamberlam G, Boyer A, St-Jean G, Brind'Amour J, Boerboom D. Sustained YAP1 signaling alters the fates of lutein and M?llerian mesenchymal cells in mice. Reproduction. 2025 08 01; 170(2).

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Wu Y, Wang Y, Liu Q, Zhu LJ, Gao H, Cui M, Liu J, Zhao P, Liu J, Chen L, Wang J, Zeng W, Woodruff TK, Zeng S. Conserved microRNA mediates heating tolerance in germ cells versus surrounding somatic cells. RNA Biol. 2019 10; 16(10):1494-1503.

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Lipskind S, Lindsey JS, Gerami-Naini B, Eaton JL, O'Connell D, Kiezun A, Ho JWK, Ng N, Parasar P, Ng M, Nickerson M, Demirci U, Maas R, Anchan RM. An Embryonic and Induced Pluripotent Stem Cell Model for Ovarian Granulosa Cell Development and Steroidogenesis. Reprod Sci. 2018 05; 25(5):712-726.

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Kano M, Sosulski AE, Zhang L, Saatcioglu HD, Wang D, Nagykery N, Sabatini ME, Gao G, Donahoe PK, P?pin D. AMH/MIS as a contraceptive that protects the ovarian reserve during chemotherapy. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):E1688-E1697.

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Anchan R, Gerami-Naini B, Lindsey JS, Ho JW, Kiezun A, Lipskind S, Ng N, LiCausi JA, Kim CS, Brezina P, Tuschl T, Maas R, Kearns WG, Williams Z. Efficient differentiation of steroidogenic and germ-like cells from epigenetically-related iPSCs derived from ovarian granulosa cells. PLoS One. 2015; 10(3):e0119275.

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Griffith GJ, Trask MC, Hiller J, Walentuk M, Pawlak JB, Tremblay KD, Mager J. Yin-yang1 is required in the mammalian oocyte for follicle expansion. Biol Reprod. 2011 Apr; 84(4):654-63.

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Combelles CM, Holick EA, Paolella LJ, Walker DC, Wu Q. Profiling of superoxide dismutase isoenzymes in compartments of the developing bovine antral follicles. Reproduction. 2010 May; 139(5):871-81.

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Xia Y, Yu PB, Sidis Y, Beppu H, Bloch KD, Schneyer AL, Lin HY. Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. J Biol Chem. 2007 Jun 22; 282(25):18129-18140.

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Schacht V, Dadras SS, Johnson LA, Jackson DG, Hong YK, Detmar M. Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. Am J Pathol. 2005 Mar; 166(3):913-21.

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Fujiwara T, Sidis Y, Welt C, Lambert-Messerlian G, Fox J, Taylor A, Schneyer A. Dynamics of inhibin subunit and follistatin mRNA during development of normal and polycystic ovary syndrome follicles. J Clin Endocrinol Metab. 2001 Sep; 86(9):4206-15.

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