 Interleukin-18
"Interleukin-18" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK CELLS and CYTOTOXIC T-LYMPHOCYTES, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.
| Descriptor ID |
D020382
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| MeSH Number(s) |
D12.644.276.374.465.518 D12.776.467.374.465.518 D23.529.374.465.518
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| Concept/Terms |
Interleukin-18- Interleukin-18
- Interleukin 18
- IFN-gamma-Inducing Factor
- IL-18
- Interferon-gamma Inducing Factor
- Inducing Factor, Interferon-gamma
- Interferon gamma Inducing Factor
- Interferon-gamma-Inducing Factor
- IFN-gamma Inducing Factor
- IFN gamma Inducing Factor
- Inducing Factor, IFN-gamma
- IL18
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Below are MeSH descriptors whose meaning is more general than "Interleukin-18".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-18".
This graph shows the total number of publications written about "Interleukin-18" by people in this website by year, and whether "Interleukin-18" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 1 | 2 | | 2003 | 0 | 2 | 2 | | 2004 | 1 | 0 | 1 | | 2005 | 1 | 0 | 1 | | 2006 | 1 | 2 | 3 | | 2008 | 1 | 3 | 4 | | 2009 | 2 | 0 | 2 | | 2010 | 0 | 3 | 3 | | 2011 | 0 | 3 | 3 | | 2012 | 1 | 2 | 3 | | 2013 | 1 | 2 | 3 | | 2014 | 1 | 2 | 3 | | 2015 | 2 | 5 | 7 | | 2016 | 1 | 1 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Interleukin-18" by people in Profiles.
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Sokolova M, Vinge LE, Alfsnes K, Olsen MB, Eide L, Kaasbøll OJ, Attramadal H, Torp MK, Fosshaug LE, Rashidi A, Lien E, Finsen AV, Sandanger Ø, Aukrust P, Ranheim T, Yndestad A. Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts. Biochim Biophys Acta. 2017 02; 1862(2):234-245.
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Ratner D, Orning MP, Starheim KK, Marty-Roix R, Proulx MK, Goguen JD, Lien E. Manipulation of Interleukin-1ß and Interleukin-18 Production by Yersinia pestis Effectors YopJ and YopM and Redundant Impact on Virulence. J Biol Chem. 2016 May 06; 291(19):9894-905.
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Levy M, Thaiss CA, Zeevi D, Dohnalová L, Zilberman-Schapira G, Mahdi JA, David E, Savidor A, Korem T, Herzig Y, Pevsner-Fischer M, Shapiro H, Christ A, Harmelin A, Halpern Z, Latz E, Flavell RA, Amit I, Segal E, Elinav E. Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling. Cell. 2015 Dec 3; 163(6):1428-43.
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Singamsetty S, Shah FA, Guo L, Watanabe Y, McDonald S, Sharma R, Zhang Y, Alonso LC, O'Donnell CP, McVerry BJ. Early initiation of low-level parenteral dextrose induces an accelerated diabetic phenotype in septic C57BL/6J mice. Appl Physiol Nutr Metab. 2016 Jan; 41(1):12-9.
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Ystgaard MB, Sejersted Y, Løberg EM, Lien E, Yndestad A, Saugstad OD. Early Upregulation of NLRP3 in the Brain of Neonatal Mice Exposed to Hypoxia-Ischemia: No Early Neuroprotective Effects of NLRP3 Deficiency. Neonatology. 2015; 108(3):211-9.
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Cero FT, Hillestad V, Sjaastad I, Yndestad A, Aukrust P, Ranheim T, Lunde IG, Olsen MB, Lien E, Zhang L, Haugstad SB, Løberg EM, Christensen G, Larsen KO, Skjønsberg OH. Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice. Am J Physiol Lung Cell Mol Physiol. 2015 Aug 15; 309(4):L378-87.
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Szabo G, Petrasek J. Inflammasome activation and function in liver disease. Nat Rev Gastroenterol Hepatol. 2015 Jul; 12(7):387-400.
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Brandstetter C, Mohr LK, Latz E, Holz FG, Krohne TU. Light induces NLRP3 inflammasome activation in retinal pigment epithelial cells via lipofuscin-mediated photooxidative damage. J Mol Med (Berl). 2015 Aug; 93(8):905-16.
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Vanaja SK, Rathinam VA, Fitzgerald KA. Mechanisms of inflammasome activation: recent advances and novel insights. Trends Cell Biol. 2015 May; 25(5):308-15.
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Suschak JJ, Wang S, Fitzgerald KA, Lu S. Identification of Aim2 as a sensor for DNA vaccines. J Immunol. 2015 Jan 15; 194(2):630-6.
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