Genetic Vectors

"Genetic Vectors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.

Descriptor ID	D005822
MeSH Number(s)	G05.360.337
Concept/Terms	Genetic Vectors Genetic Vectors Genetic Vector Vector, Genetic Vectors, Genetic Shuttle Vectors Shuttle Vectors Shuttle Vector Vector, Shuttle Vectors, Shuttle Cloning Vectors Cloning Vectors Cloning Vector Vector, Cloning Vectors, Cloning

Below are MeSH descriptors whose meaning is more general than "Genetic Vectors".

Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Genetic Vectors [G05.360.337]

Below are MeSH descriptors whose meaning is related to "Genetic Vectors".

Below are MeSH descriptors whose meaning is more specific than "Genetic Vectors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Genetic Vectors" by people in this website by year, and whether "Genetic Vectors" was a major or minor topic of these publications.

Bar chart showing 556 publications over 31 distinct years, with a maximum of 31 publications in 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	6	4	10
1996	5	3	8
1997	3	6	9
1998	4	8	12
1999	4	3	7
2000	6	5	11
2001	9	4	13
2002	15	15	30
2003	9	16	25
2004	11	5	16
2005	9	13	22
2006	3	4	7
2007	12	11	23
2008	14	11	25
2009	8	13	21
2010	11	8	19
2011	8	11	19
2012	4	8	12
2013	13	12	25
2014	4	17	21
2015	7	15	22
2016	7	12	19
2017	12	19	31
2018	11	16	27
2019	10	13	23
2020	14	6	20
2021	9	7	16
2022	5	4	9
2023	4	5	9
2024	15	9	24
2025	8	13	21

Below are the most recent publications written about "Genetic Vectors" by people in Profiles.

Lonfat N, Moreno-Leon L, Punzo C, Khanna H. Update on Gene Therapy Clinical Trials for Eye Diseases. Hum Gene Ther. 2025 Oct; 36(19-20):1287-1300.

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Xing R, Xu M, Reil D, Destefano A, Cui M, Liu N, Liang J, Xu G, Luo L, Xu M, Zhang F, Tai PWL, Wei Y, Gruntman AM, Flotte TR, Gao G, Wang D. A single amino acid variant in the variable region I of AAV capsid confers liver detargeting. PLoS Pathog. 2025 Sep; 21(9):e1013533.

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Yang YS, Kim MJ, Chaugule S, Mayer E, DeSouza N, Ma H, Xie J, Lee KY, Li S, Gravallese E, Gao G, Shim JH. Nature-inspired IL-1 targeted therapy to treat chronic inflammatory diseases. Mol Ther. 2025 Dec 03; 33(12):6379-6397.

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Bamidele N, Pires-Ferreira D, Zheng C, Destefano A, Cheng H, Tang Q, Cao Y, Xie J, Gao G, Gruntman A, Sontheimer E, Flotte TR, Xue W. A compact base editor rescues AATD-associated liver and lung disease in mouse models. Mol Ther. 2025 Nov 05; 33(11):5817-5828.

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Hahn PA, Shandilya S, da Costa LAB, da Silva LCF, O'Hagan D, Liang B, Engelman K, Gardner MR, Gao G, Fuchs SP, Martinez-Navio JM, Desrosiers RC, Ardeshir A, Magnani DM, Martins MA. The Immunogenicity of AAV-Encoded HIV-1 bNAbs in Rhesus Macaques Is Unaffected by a Short Course of the Immunomodulator CTLA4Ig. AIDS Res Hum Retroviruses. 2025 Dec; 41(12):567-579.

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Daci R, Shazeeb MS, Owusu-Adjei B, K?hn A, King R, Parzych J, Spanakis SG, Moser RP, Flotte TR, Cataltepe OI. Robot-assisted intrathalamic infusion for gene therapy in young children: surgical considerations. J Neurosurg Pediatr. 2025 Nov 01; 36(5):609-620.

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Eichler F, Cataltepe OI, Daci R, Puri AS, Taghian T, Jiang X, Shazeeb MS, Kuhn A, Hader A, Celik H, Vardar Z, Lewis CJ, Artinian R, Nagy A, Vachha B, Thompson R, Gallagher T, Bateman S, Parzych J, Spanakis SG, Vaughn TA, Pier K, De Boever E, Abbott MA, D Ambrosio E, Kokoski D, Blackwood M, Drummond E, Ratai EM, Townsend EL, McLaughlin H, Tifft CJ, Keeler AM, Sena-Esteves M, Gray-Edwards HL, Flotte TR. Dual-vector rAAVrh8 gene therapy for GM2 gangliosidosis: a phase 1/2 trial. Nat Med. 2025 Sep; 31(9):2927-2935.

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Ardeshir A, O'Hagan D, Mehta I, Shandilya S, Hopkins LLJ, Adamson L, Kuroda MJ, Hahn PA, da Costa LAB, Fuchs SP, Martinez-Navio JM, Gardner MR, Van Rompay KKA, Magnani DM, Lifson JD, Gao G, Farzan M, Desrosiers RC, Das J, Martins MA. Determinants of successful AAV-vectored delivery of HIV-1 bNAbs in early life. Nature. 2025 Sep; 645(8082):1020-1028.

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Iwanowicz A, Boudi A, Seeley C, Sapp E, Miller R, Liu S, Chase K, Shing K, Batista AR, Siena-Esteves M, Aronin N, DiFiglia M, Kegel-Gleason KB. Intrastriatal Delivery of a Zinc Finger Protein Targeting the Mutant HTT Gene Allele Obviates Lipid Phenotypes in Brain and Plasma in Huntington's Disease?Mice. Hum Gene Ther. 2025 Aug; 36(15-16):1083-1094.

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Wang Y, Liu J, Zhu S, Hu S, Chen X, Mandon E, Tran NT, Zhang S, Qi Y, Ma H, He R, Cao Y, Su Q, Gallagher TL, Li Z, Zhou C, Tai PWL, Gao G, Xie J. miR-375 protects against acetaminophen-induced acute liver failure by orchestrating pharmacogene expression. Mol Ther. 2025 Oct 01; 33(10):4874-4888.

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