"Transcription Factor 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3' sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome, a severe developmental disorder.
| Descriptor ID |
D000073940
|
| MeSH Number(s) |
D12.776.260.108.092.937 D12.776.930.125.500.937
|
| Concept/Terms |
Transcription Factor 4- Transcription Factor 4
- TCF4 Transcription Factor
- Transcription Factor, TCF4
- TCF-4 Transcription Factor
- TCF 4 Transcription Factor
- Transcription Factor, TCF-4
- TCF-4 Protein
- TCF 4 Protein
|
Below are MeSH descriptors whose meaning is more general than "Transcription Factor 4".
Below are MeSH descriptors whose meaning is more specific than "Transcription Factor 4".
This graph shows the total number of publications written about "Transcription Factor 4" by people in this website by year, and whether "Transcription Factor 4" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Transcription Factor 4" by people in Profiles.
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Hu J, Rong Z, Gong X, Zhou Z, Sharma VK, Xing C, Watts JK, Corey DR, Mootha VV. Oligonucleotides targeting TCF4 triplet repeat expansion inhibit RNA foci and mis-splicing in Fuchs' dystrophy. Hum Mol Genet. 2018 03 15; 27(6):1015-1026.
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Kapoor A, Li HJ, Leiter AB. Intestinal development: the many faces of Wnt signaling. Gastroenterology. 2007 Aug; 133(2):710-2.
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Kim BM, Mao J, Taketo MM, Shivdasani RA. Phases of canonical Wnt signaling during the development of mouse intestinal epithelium. Gastroenterology. 2007 Aug; 133(2):529-38.