"Zinc Finger Protein Gli3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES.
| Descriptor ID |
D000074290
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| MeSH Number(s) |
D12.776.260.522.875 D12.776.260.703.900 D12.776.930.375.875 D12.776.930.780.972
|
| Concept/Terms |
Zinc Finger Protein Gli3- Zinc Finger Protein Gli3
- Glioma-Associated Oncogene Family Zinc Finger 3 Protein
- Glioma Associated Oncogene Family Zinc Finger 3 Protein
- GLI-Kruppel Family Member 3 Protein
- GLI Kruppel Family Member 3 Protein
|
Below are MeSH descriptors whose meaning is more general than "Zinc Finger Protein Gli3".
Below are MeSH descriptors whose meaning is more specific than "Zinc Finger Protein Gli3".
This graph shows the total number of publications written about "Zinc Finger Protein Gli3" by people in this website by year, and whether "Zinc Finger Protein Gli3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2016 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Zinc Finger Protein Gli3" by people in Profiles.
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Taroc EZM, Naik AS, Lin JM, Peterson NB, Keefe DL, Genis E, Fuchs G, Balasubramanian R, Forni PE. Gli3 Regulates Vomeronasal Neurogenesis, Olfactory Ensheathing Cell Formation, and GnRH-1 Neuronal Migration. J Neurosci. 2020 01 08; 40(2):311-326.
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Tang CM, Lee TE, Syed SA, Burgoyne AM, Leonard SY, Gao F, Chan JC, Shi E, Chmielecki J, Morosini D, Wang K, Ross JS, Kendrick ML, Bardsley MR, Siena M, Mao J, Harismendy O, Ordog T, Sicklick JK. Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression. Oncotarget. 2016 Nov 29; 7(48):78226-78241.
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Rajurkar M, Huang H, Cotton JL, Brooks JK, Sicklick J, McMahon AP, Mao J. Distinct cellular origin and genetic requirement of Hedgehog-Gli in postnatal rhabdomyosarcoma genesis. Oncogene. 2014 Nov 13; 33(46):5370-8.
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Huang H, Cotton JL, Wang Y, Rajurkar M, Zhu LJ, Lewis BC, Mao J. Specific requirement of Gli transcription factors in Hedgehog-mediated intestinal development. J Biol Chem. 2013 Jun 14; 288(24):17589-96.
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Tyurina OV, Guner B, Popova E, Feng J, Schier AF, Kohtz JD, Karlstrom RO. Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signaling. Dev Biol. 2005 Jan 15; 277(2):537-56.
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McDermott A, Gustafsson M, Elsam T, Hui CC, Emerson CP, Borycki AG. Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation. Development. 2005 Jan; 132(2):345-57.