Hypercholesterolemia induces oxidant stress that accelerates the ageing of hematopoietic stem cells.

Tie G, Messina KE, Yan J, Messina JA, Messina LM. Hypercholesterolemia induces oxidant stress that accelerates the ageing of hematopoietic stem cells. J Am Heart Assoc. 2014 Jan 27; 3(1):e000241.

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subject areas

Animals
Antioxidants
Apolipoproteins E
Cell Proliferation
Cells, Cultured
Cellular Senescence
Cyclin-Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinase Inhibitor p21
Cyclin-Dependent Kinase Inhibitor p27
Disease Models, Animal
Hematopoietic Stem Cells
Hypercholesterolemia
Lipoproteins, LDL
Mice
Mice, Inbred C57BL
Mice, Knockout
Oxidative Stress
p38 Mitogen-Activated Protein Kinases
Phenotype
Reactive Oxygen Species
Receptor, Notch1
Telomere Shortening
Time Factors

authors with profiles

Louis M Messina MD