Methylation

"Methylation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Addition of methyl groups. In histo-chemistry methylation is used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid. (From Stedman, 25th ed)

Descriptor ID	D008745
MeSH Number(s)	G02.111.035.538 G02.607.094.538 G03.059.538
Concept/Terms	Methylation Methylation Methylations

Below are MeSH descriptors whose meaning is more general than "Methylation".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Alkylation [G02.111.035]
Methylation [G02.111.035.538]
Organic Chemistry Phenomena [G02.607]
Alkylation [G02.607.094]
Methylation [G02.607.094.538]
Metabolism [G03]
Alkylation [G03.059]
Methylation [G03.059.538]

Below are MeSH descriptors whose meaning is related to "Methylation".

Below are MeSH descriptors whose meaning is more specific than "Methylation".

Methylation
DNA Methylation

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Methylation" by people in this website by year, and whether "Methylation" was a major or minor topic of these publications.

Bar chart showing 92 publications over 25 distinct years, with a maximum of 7 publications in 2012

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
1995	2	2
1996	1	1
2002	4	4
2003	3	3
2004	1	1
2005	4	4
2006	2	2
2007	4	4
2008	2	2
2009	3	3
2010	6	6
2011	4	4
2012	7	7
2013	6	6
2014	6	6
2015	5	5
2016	5	5
2017	5	5
2018	2	2
2019	4	4
2020	2	2
2021	6	6
2022	3	3
2023	2	2
2024	3	3

Below are the most recent publications written about "Methylation" by people in Profiles.

Jiao AL, Sendinc E, Zee BM, Wallner F, Shi Y. An E2 ubiquitin-conjugating enzyme links diubiquitinated H2B to H3K27M oncohistone function. Proc Natl Acad Sci U S A. 2024 Nov 26; 121(48):e2416614121.

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Brown BA, Myers PJ, Adair SJ, Pitarresi JR, Sah-Teli SK, Campbell LA, Hart WS, Barbeau MC, Leong K, Seyler N, Kane W, Lee KE, Stelow E, Jones M, Simon MC, Koivunen P, Bauer TW, Stanger BZ, Lazzara MJ. A Histone Methylation-MAPK Signaling Axis Drives Durable Epithelial-Mesenchymal Transition in Hypoxic Pancreatic Cancer. Cancer Res. 2024 Jun 04; 84(11):1764-1780.

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Hsieh HC, Huang IH, Chang SW, Chen PL, Su YC, Wang S, Tsai WJ, Chen PH, Aroian RV, Chen CS. PRMT-7/PRMT7 activates HLH-30/TFEB to guard plasma membrane integrity compromised by bacterial pore-forming toxins. Autophagy. 2024 06; 20(6):1335-1358.

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Mangalhara KC, Varanasi SK, Johnson MA, Burns MJ, Rojas GR, Esparza Molt? PB, Sainz AG, Tadepalle N, Abbott KL, Mendiratta G, Chen D, Farsakoglu Y, Kunchok T, Hoffmann FA, Parisi B, Rincon M, Vander Heiden MG, Bosenberg M, Hargreaves DC, Kaech SM, Shadel GS. Manipulating mitochondrial electron flow enhances tumor immunogenicity. Science. 2023 09 22; 381(6664):1316-1323.

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Sendinc E, Shi Y. RNA m6A methylation across the transcriptome. Mol Cell. 2023 02 02; 83(3):428-441.

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Spracklin G, Abdennur N, Imakaev M, Chowdhury N, Pradhan S, Mirny LA, Dekker J. Diverse silent chromatin states modulate genome compartmentalization and loop extrusion barriers. Nat Struct Mol Biol. 2023 Jan; 30(1):38-51.

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Freeman AH, Tembiwa K, Brenner JR, Chase MR, Fortune SM, Morita YS, Boutte CC. Arginine methylation sites on SepIVA help balance elongation and septation in Mycobacterium smegmatis. Mol Microbiol. 2023 02; 119(2):208-223.

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Huang L, Zhang XO, Rozen EJ, Sun X, Sallis B, Verdejo-Torres O, Wigglesworth K, Moon D, Huang T, Cavaretta JP, Wang G, Zhang L, Shohet JM, Lee MM, Wu Q. PRMT5 activates AKT via methylation to promote tumor metastasis. Nat Commun. 2022 07 08; 13(1):3955.

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Bighetti-Trevisan RL, Almeida LO, Castro-Raucci LMS, Gordon JAR, Tye CE, Stein GS, Lian JB, Stein JL, Rosa AL, Beloti MM. Titanium with nanotopography attenuates the osteoclast-induced disruption of osteoblast differentiation by regulating histone methylation. Biomater Adv. 2022 Mar; 134:112548.

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Pauli C, Kienh?fer M, G?llner S, M?ller-Tidow C. Epitranscriptomic modifications in acute myeloid leukemia: m6A and 2'-O-methylation as targets for novel therapeutic strategies. Biol Chem. 2021 Nov 25; 402(12):1531-1546.

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