SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons.

Dobbin MM, Madabhushi R, Pan L, Chen Y, Kim D, Gao J, Ahanonu B, Pao PC, Qiu Y, Zhao Y, Tsai LH. SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons. Nat Neurosci. 2013 Aug; 16(8):1008-15.

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subject areas

Acetylation
Amino Acid Sequence
Animals
Ataxia Telangiectasia Mutated Proteins
Cell Cycle Proteins
Cell Line
Cerebral Cortex
Comet Assay
DNA Breaks, Double-Stranded
DNA End-Joining Repair
DNA-Binding Proteins
Enzyme Activation
Etoposide
Genetic Vectors
Genomic Instability
HEK293 Cells
Hippocampus
Histone Deacetylase 1
Humans
Mice
Mice, Transgenic
Molecular Sequence Data
Neurons
Phosphorylation
Protein Interaction Mapping
Protein Processing, Post-Translational
Recombinant Fusion Proteins
RNA Interference
RNA, Small Interfering
Sirtuin 1
Tumor Suppressor Proteins

authors with profiles

Dohoon Kim PhD