"Ataxin-3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A deubiquitinating enzyme of the ATAXINS family. It functions in protein homeostasis, GENETIC TRANSCRIPTION; CYTOSKELETON regulation, and MYOGENESIS. CAG TRINUCLEOTIDE REPEAT EXPANSION in the Ataxin-3 gene coding region is associated with spinocerebellar ataxia-3 (MACHADO-JOSEPH DISEASE).
| Descriptor ID |
D000067699
|
| MeSH Number(s) |
D08.811.037.250 D12.776.631.069.875 D12.776.660.075.875
|
| Concept/Terms |
Ataxin-3- Ataxin-3
- Ataxin 3
- SCA3 Protein
- Ataxin-3 Protein
- Ataxin 3 Protein
- Machado-Joseph Disease Protein
- Machado Joseph Disease Protein
- Spinocerebellar Ataxia 3 Protein
- ATXN3 Protein
|
Below are MeSH descriptors whose meaning is more general than "Ataxin-3".
Below are MeSH descriptors whose meaning is more specific than "Ataxin-3".
This graph shows the total number of publications written about "Ataxin-3" by people in this website by year, and whether "Ataxin-3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "Ataxin-3" by people in Profiles.
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Hu J, Gagnon KT, Liu J, Watts JK, Syeda-Nawaz J, Bennett CF, Swayze EE, Randolph J, Chattopadhyaya J, Corey DR. Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs. Biol Chem. 2011 Apr; 392(4):315-25.
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Menzies FM, Hourez R, Imarisio S, Raspe M, Sadiq O, Chandraratna D, O'Kane C, Rock KL, Reits E, Goldberg AL, Rubinsztein DC. Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy. Hum Mol Genet. 2010 Dec 01; 19(23):4573-86.
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Takiyama Y, Igarashi S, Rogaeva EA, Endo K, Rogaev EI, Tanaka H, Sherrington R, Sanpei K, Liang Y, Saito M, et al. Evidence for inter-generational instability in the CAG repeat in the MJD1 gene and for conserved haplotypes at flanking markers amongst Japanese and Caucasian subjects with Machado-Joseph disease. Hum Mol Genet. 1995 Jul; 4(7):1137-46.