Transcription Factor HES-1
"Transcription Factor HES-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A basic-helix-loop-helix transcription factor that functions as a transcriptional repressor for genes transcribed by bHLH proteins. For example, it may negatively regulate MYOGENESIS by inhibiting MyoD1 and ASH1 proteins. It is also required for the stability of FANCONI ANEMIA COMPLEMENTATION GROUP PROTEINS and their localization to the cell nucleus in response to DNA DAMAGE.
| Descriptor ID |
D000072056
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| MeSH Number(s) |
D12.776.260.103.844 D12.776.930.125.844
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| Concept/Terms |
Transcription Factor HES-1- Transcription Factor HES-1
- HES-1, Transcription Factor
- Transcription Factor HES 1
- Hairy-Like Transcription Factor
- Hairy Like Transcription Factor
- Transcription Factor, Hairy-Like
- Hairy and Enhancer of Split 1 Protein
|
Below are MeSH descriptors whose meaning is more general than "Transcription Factor HES-1".
Below are MeSH descriptors whose meaning is more specific than "Transcription Factor HES-1".
This graph shows the total number of publications written about "Transcription Factor HES-1" by people in this website by year, and whether "Transcription Factor HES-1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2014 | 0 | 2 | 2 |
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Below are the most recent publications written about "Transcription Factor HES-1" by people in Profiles.
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Bai G, Cheung I, Shulha HP, Coelho JE, Li P, Dong X, Jakovcevski M, Wang Y, Grigorenko A, Jiang Y, Hoss A, Patel K, Zheng M, Rogaev E, Myers RH, Weng Z, Akbarian S, Chen JF. Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains. Hum Mol Genet. 2015 Mar 01; 24(5):1441-56.
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Chao CH, Chang CC, Wu MJ, Ko HW, Wang D, Hung MC, Yang JY, Chang CJ. MicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis. J Clin Invest. 2014 Jul; 124(7):3093-106.
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Zhang Y, Lian JB, Stein JL, van Wijnen AJ, Stein GS. The Notch-responsive transcription factor Hes-1 attenuates osteocalcin promoter activity in osteoblastic cells. J Cell Biochem. 2009 Oct 15; 108(3):651-9.
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Palaga T, Buranaruk C, Rengpipat S, Fauq AH, Golde TE, Kaufmann SH, Osborne BA. Notch signaling is activated by TLR stimulation and regulates macrophage functions. Eur J Immunol. 2008 Jan; 38(1):174-83.
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Bansal R, You SH, Herzig CT, Zoeller RT. Maternal thyroid hormone increases HES expression in the fetal rat brain: an effect mimicked by exposure to a mixture of polychlorinated biphenyls (PCBs). Brain Res Dev Brain Res. 2005 Apr 21; 156(1):13-22.