Tissue Distribution

"Tissue Distribution" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.

Descriptor ID	D014018
MeSH Number(s)	G03.787.917 G07.690.725.949
Concept/Terms	Tissue Distribution Tissue Distribution Distribution, Tissue Distributions, Tissue Tissue Distributions

Below are MeSH descriptors whose meaning is more general than "Tissue Distribution".

Biological Sciences [G]
Metabolism [G03]
Pharmacokinetics [G03.787]
Tissue Distribution [G03.787.917]
Physiological Phenomena [G07]
Pharmacological and Toxicological Phenomena [G07.690]
Pharmacokinetics [G07.690.725]
Tissue Distribution [G07.690.725.949]

Below are MeSH descriptors whose meaning is related to "Tissue Distribution".

Below are MeSH descriptors whose meaning is more specific than "Tissue Distribution".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Tissue Distribution" by people in this website by year, and whether "Tissue Distribution" was a major or minor topic of these publications.

Bar chart showing 167 publications over 31 distinct years, with a maximum of 13 publications in 2004

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
1993	6	6
1994	4	4
1995	3	3
1996	5	5
1997	3	3
1998	5	5
1999	9	9
2000	7	7
2001	5	5
2002	5	5
2003	10	10
2004	13	13
2005	9	9
2006	9	9
2007	6	6
2008	4	4
2009	6	6
2010	3	3
2011	5	5
2012	3	3
2013	6	6
2014	3	3
2015	7	7
2016	2	2
2017	5	5
2018	5	5
2019	5	5
2020	4	4
2021	4	4
2022	4	4
2023	2	2

Below are the most recent publications written about "Tissue Distribution" by people in Profiles.

Benson JM, Wang G, Hutt JA, Wu G, Kaminsky SM, Cram S, Barur R, Donahue JK. Preclinical safety and biodistribution assessment of Ad-KCNH2-G628S administered via atrial painting in New Zealand white rabbits. Basic Clin Pharmacol Toxicol. 2023 Aug; 133(2):179-193.

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Gupta A, Dhiman A, Sood A, Bharadwaj R, Silverman N, Agrawal G. Dextran/eudragit S-100 based redox sensitive nanoparticles for colorectal cancer therapy. Nanoscale. 2023 Feb 16; 15(7):3273-3283.

View in: PubMed
Sood A, Gupta A, Bharadwaj R, Ranganath P, Silverman N, Agrawal G. Biodegradable disulfide crosslinked chitosan/stearic acid nanoparticles for dual drug delivery for colorectal cancer. Carbohydr Polym. 2022 Oct 15; 294:119833.

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Hsueh YC, Wang Y, Riding RL, Catalano DE, Lu YJ, Richmond JM, Siegel DL, Rusckowski M, Stanley JR, Harris JE. A Keratinocyte-Tethered Biologic Enables Location-Precise Treatment in Mouse Vitiligo. J Invest Dermatol. 2022 Dec; 142(12):3294-3303.

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Gross AL, Gray-Edwards HL, Bebout CN, Ta NL, Nielsen K, Brunson BL, Lopez Mercado KR, Osterhoudt DE, Batista AR, Maitland S, Seyfried TN, Sena-Esteves M, Martin DR. Intravenous delivery of adeno-associated viral gene therapy in feline GM1 gangliosidosis. Brain. 2022 04 18; 145(2):655-669.

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Taghian T, Gallagher J, Batcho E, Pullan C, Kuchel T, Denney T, Perumal R, Moore S, Muirhead R, Herde P, Johns D, Christou C, Taylor A, Passler T, Pulaparthi S, Hall E, Chandra S, O'Neill CA, Gray-Edwards H. Brain Alterations in Aged OVT73 Sheep Model of Huntington's Disease: An MRI Based Approach. J Huntingtons Dis. 2022; 11(4):391-406.

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Fedeli S, Im J, Gopalakrishnan S, Elia JL, Gupta A, Kim D, Rotello VM. Nanomaterial-based bioorthogonal nanozymes for biological applications. Chem Soc Rev. 2021 Dec 13; 50(24):13467-13480.

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Myerson JW, Patel PN, Rubey KM, Zamora ME, Zaleski MH, Habibi N, Walsh LR, Lee YW, Luther DC, Ferguson LT, Marcos-Contreras OA, Glassman PM, Mazaleuskaya LL, Johnston I, Hood ED, Shuvaeva T, Wu J, Zhang HY, Gregory JV, Kiseleva RY, Nong J, Grosser T, Greineder CF, Mitragotri S, Worthen GS, Rotello VM, Lahann J, Muzykantov VR, Brenner JS. Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation. Nat Nanotechnol. 2022 01; 17(1):86-97.

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Sun Y, Wang Q, Wu X, Li F, Song M, Wang M, Cai X, Li Z, Gao Z, Zheng J, Qi C, Sun J, Xiao H. Gastrointestinal biotransformation and tissue distribution of pterostilbene after long-term dietary administration in mice. Food Chem. 2022 Mar 15; 372:131213.

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Kondratov O, Kondratova L, Mandel RJ, Coleman K, Savage MA, Gray-Edwards HL, Ness TJ, Rodriguez-Lebron E, Bell RD, Rabinowitz J, Gamlin PD, Zolotukhin S. A comprehensive study of a 29-capsid AAV library in a non-human primate central nervous system. Mol Ther. 2021 09 01; 29(9):2806-2820.

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