Tissue Distribution

"Tissue Distribution" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.

Descriptor ID	D014018
MeSH Number(s)	G03.787.917 G07.690.725.949
Concept/Terms	Tissue Distribution Tissue Distribution Distribution, Tissue Distributions, Tissue Tissue Distributions

Below are MeSH descriptors whose meaning is more general than "Tissue Distribution".

Biological Sciences [G]
Metabolism [G03]
Pharmacokinetics [G03.787]
Tissue Distribution [G03.787.917]
Physiological Phenomena [G07]
Pharmacological and Toxicological Phenomena [G07.690]
Pharmacokinetics [G07.690.725]
Tissue Distribution [G07.690.725.949]

Below are MeSH descriptors whose meaning is related to "Tissue Distribution".

Below are MeSH descriptors whose meaning is more specific than "Tissue Distribution".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Tissue Distribution" by people in this website by year, and whether "Tissue Distribution" was a major or minor topic of these publications.

Bar chart showing 190 publications over 31 distinct years, with a maximum of 12 publications in 2004

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
1995	5	5
1996	9	9
1997	7	7
1998	5	5
1999	10	10
2000	10	10
2001	11	11
2002	11	11
2003	11	11
2004	12	12
2005	9	9
2006	9	9
2007	6	6
2008	4	4
2009	7	7
2010	3	3
2011	5	5
2012	3	3
2013	6	6
2014	3	3
2015	7	7
2016	2	2
2017	5	5
2018	5	5
2019	5	5
2020	4	4
2021	4	4
2022	4	4
2023	2	2
2024	5	5
2025	1	1

Below are the most recent publications written about "Tissue Distribution" by people in Profiles.

Walkey CJ, Snow KJ, Bulcha J, Cox AR, Martinez AE, Ljungberg MC, Lanza DG, De Giorgi M, Chuecos MA, Alves-Bezerra M, Suarez CF, Hartig SM, Hilsenbeck SG, Hsu CW, Saville E, Gaitan Y, Duryea J, Hannigan S, Dickinson ME, Mirochnitchenko O, Wang D, Lutz CM, Heaney JD, Gao G, Murray SA, Lagor WR. A comprehensive atlas of AAV tropism in the mouse. Mol Ther. 2025 Mar 05; 33(3):1282-1299.

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Raman V, Hall CL, Wetherby VE, Whitney SA, Van Dessel N, Forbes NS. Controlling intracellular protein delivery, tumor colonization and tissue distribution using flhDC in clinically relevant ?sseJ Salmonella. Mol Ther. 2025 Feb 05; 33(2):649-669.

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Zhang W, Oh JH, Zhang W, Aldrich CC, Sirianni RW, Elmquist WF. Central nervous system distributional kinetics of selected histone deacetylase inhibitors. J Pharmacol Exp Ther. 2025 Jan; 392(1):100014.

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Benatti HR, Anagnostakou V, Taghian T, Hall EF, Nath S, Heilman CB, Beneduce BM, Leporati A, Raskett C, Epshtein M, King R, Gounis MJ, Malek AM, Gray-Edwards HL. A minimally invasive endovascular approach to the cerebellopontine angle cistern enables broad CNS biodistribution of scAAV9-CB-GFP. Mol Ther. 2024 Oct 02; 32(10):3346-3355.

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Agrohia DK, Goswami R, Jantarat T, ?i?ek YA, Thongsukh K, Jeon T, Bell JM, Rotello VM, Vachet RW. Suborgan Level Quantitation of Proteins in Tissues Delivered by Polymeric Nanocarriers. ACS Nano. 2024 Jul 02; 18(26):16808-16818.

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Zhang H, Kelly K, Lee J, Echeverria D, Cooper D, Panwala R, Amrani N, Chen Z, Gaston N, Wagh A, Newby GA, Xie J, Liu DR, Gao G, Wolfe SA, Khvorova A, Watts JK, Sontheimer EJ. Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo. Nucleic Acids Res. 2024 Jan 25; 52(2):977-997.

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Benson JM, Wang G, Hutt JA, Wu G, Kaminsky SM, Cram S, Barur R, Donahue JK. Preclinical safety and biodistribution assessment of Ad-KCNH2-G628S administered via atrial painting in New Zealand white rabbits. Basic Clin Pharmacol Toxicol. 2023 Aug; 133(2):179-193.

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Gupta A, Dhiman A, Sood A, Bharadwaj R, Silverman N, Agrawal G. Dextran/eudragit S-100 based redox sensitive nanoparticles for colorectal cancer therapy. Nanoscale. 2023 Feb 16; 15(7):3273-3283.

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Sood A, Gupta A, Bharadwaj R, Ranganath P, Silverman N, Agrawal G. Biodegradable disulfide crosslinked chitosan/stearic acid nanoparticles for dual drug delivery for colorectal cancer. Carbohydr Polym. 2022 Oct 15; 294:119833.

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Hsueh YC, Wang Y, Riding RL, Catalano DE, Lu YJ, Richmond JM, Siegel DL, Rusckowski M, Stanley JR, Harris JE. A Keratinocyte-Tethered Biologic Enables Location-Precise Treatment in Mouse Vitiligo. J Invest Dermatol. 2022 12; 142(12):3294-3303.

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