p300-CBP Transcription Factors

"p300-CBP Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of histone acetyltransferases that is structurally-related to CREB-BINDING PROTEIN and to E1A-ASSOCIATED P300 PROTEIN. They function as transcriptional coactivators by bridging between DNA-binding TRANSCRIPTION FACTORS and the basal transcription machinery. They also modify transcription factors and CHROMATIN through ACETYLATION.

Descriptor ID	D050880
MeSH Number(s)	D08.811.913.050.134.415.500.575 D12.776.930.680
Concept/Terms	p300-CBP Transcription Factors p300-CBP Transcription Factors Transcription Factors, p300-CBP p300 CBP Transcription Factors p300-CBP Coactivator Coactivator, p300-CBP p300 CBP Coactivator p300-CBP Protein p300 CBP Protein

Below are MeSH descriptors whose meaning is more general than "p300-CBP Transcription Factors".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Acyltransferases [D08.811.913.050]
Acetyltransferases [D08.811.913.050.134]
Lysine Acetyltransferases [D08.811.913.050.134.415]
Histone Acetyltransferases [D08.811.913.050.134.415.500]
p300-CBP Transcription Factors [D08.811.913.050.134.415.500.575]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Transcription Factors [D12.776.930]
p300-CBP Transcription Factors [D12.776.930.680]

Below are MeSH descriptors whose meaning is related to "p300-CBP Transcription Factors".

Below are MeSH descriptors whose meaning is more specific than "p300-CBP Transcription Factors".

p300-CBP Transcription Factors
CREB-Binding Protein
E1A-Associated p300 Protein

publications

Timeline | Most Recent

This graph shows the total number of publications written about "p300-CBP Transcription Factors" by people in this website by year, and whether "p300-CBP Transcription Factors" was a major or minor topic of these publications.

Bar chart showing 9 publications over 7 distinct years, with a maximum of 2 publications in 2004 and 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	1	1
2004	0	2	2
2007	0	1	1
2008	1	0	1
2009	0	1	1
2011	1	1	2
2020	1	0	1

Below are the most recent publications written about "p300-CBP Transcription Factors" by people in Profiles.

Karlsson E, Lindberg A, Andersson E, Jemth P. High affinity between CREBBP/p300 and NCOA evolved in vertebrates. Protein Sci. 2020 07; 29(7):1687-1691.

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Ray SK, Li HJ, Metzger E, Sch?le R, Leiter AB. CtBP and associated LSD1 are required for transcriptional activation by NeuroD1 in gastrointestinal endocrine cells. Mol Cell Biol. 2014 Jun; 34(12):2308-17.

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Sinha S, Malonia SK, Mittal SP, Mathai J, Pal JK, Chattopadhyay S. Chromatin remodelling protein SMAR1 inhibits p53 dependent transactivation by regulating acetyl transferase p300. Int J Biochem Cell Biol. 2012 Jan; 44(1):46-52.

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Pillai VB, Sundaresan NR, Samant SA, Wolfgeher D, Trivedi CM, Gupta MP. Acetylation of a conserved lysine residue in the ATP binding pocket of p38 augments its kinase activity during hypertrophy of cardiomyocytes. Mol Cell Biol. 2011 Jun; 31(11):2349-63.

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Naidu SR, Love IM, Imbalzano AN, Grossman SR, Androphy EJ. The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells. Oncogene. 2009 Jul 09; 28(27):2492-501.

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Chen W, Srinath H, Lam SS, Schiffer CA, Royer WE, Lin K. Contribution of Ser386 and Ser396 to activation of interferon regulatory factor 3. J Mol Biol. 2008 May 30; 379(2):251-60.

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Sharma A, Awasthi S, Harrod CK, Matlock EF, Khan S, Xu L, Chan S, Yang H, Thammavaram CK, Rasor RA, Burns DK, Skiest DJ, Van Lint C, Girard AM, McGee M, Monnat RJ, Harrod R. The Werner syndrome helicase is a cofactor for HIV-1 long terminal repeat transactivation and retroviral replication. J Biol Chem. 2007 Apr 20; 282(16):12048-57.

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Wong K, Sharma A, Awasthi S, Matlock EF, Rogers L, Van Lint C, Skiest DJ, Burns DK, Harrod R. HIV-1 Tat interactions with p300 and PCAF transcriptional coactivators inhibit histone acetylation and neurotrophin signaling through CREB. J Biol Chem. 2005 Mar 11; 280(10):9390-9.

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Sagar V, Zheng W, Thompson PR, Cole PA. Bisubstrate analogue structure-activity relationships for p300 histone acetyltransferase inhibitors. Bioorg Med Chem. 2004 Jun 15; 12(12):3383-90.

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Sierra J, Villagra A, Paredes R, Cruzat F, Gutierrez S, Javed A, Arriagada G, Olate J, Imschenetzky M, Van Wijnen AJ, Lian JB, Stein GS, Stein JL, Montecino M. Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D3 receptor but not p300 intrinsic histone acetyltransferase activity. Mol Cell Biol. 2003 May; 23(9):3339-51.

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