 RNA-Binding Protein FUS
"RNA-Binding Protein FUS" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multifunctional heterogeneous-nuclear ribonucleoprotein that may play a role in homologous DNA pairing and recombination. The N-terminal portion of protein is a potent transcriptional activator, while the C terminus is required for RNA binding. The name FUS refers to the fact that genetic recombination events result in fusion oncogene proteins (ONCOGENE PROTEINS, FUSION) that contain the N-terminal region of this protein. These fusion proteins have been found in myxoid liposarcoma (LIPOSARCOMA, MYXOID) and acute myeloid leukemia.
| Descriptor ID |
D034702
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| MeSH Number(s) |
D12.776.157.725.500.500.905 D12.776.624.664.700.915 D12.776.664.962.500.500.902
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| Concept/Terms |
RNA-Binding Protein FUS- RNA-Binding Protein FUS
- RNA Binding Protein FUS
- TLS Protein
- hnRNP P2
- POMp75 Protein
- Translocated in Liposarcoma Protein
- FUS RNA-Binding Protein
- FUS RNA Binding Protein
- RNA-Binding Protein, FUS
- Fusion Protein in Myxoid Liposarcoma
- FUS Protein
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Below are MeSH descriptors whose meaning is more general than "RNA-Binding Protein FUS".
Below are MeSH descriptors whose meaning is more specific than "RNA-Binding Protein FUS".
This graph shows the total number of publications written about "RNA-Binding Protein FUS" by people in this website by year, and whether "RNA-Binding Protein FUS" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 2 | 1 | 3 | | 2011 | 1 | 0 | 1 | | 2012 | 0 | 2 | 2 | | 2013 | 5 | 2 | 7 | | 2014 | 4 | 0 | 4 | | 2015 | 1 | 0 | 1 |
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Below are the most recent publications written about "RNA-Binding Protein FUS" by people in Profiles.
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Özoguz A, Uyan Ö, Birdal G, Iskender C, Kartal E, Lahut S, Ömür Ö, Agim ZS, Eken AG, Sen NE, Kavak P, Saygi C, Sapp PC, Keagle P, Parman Y, Tan E, Koç F, Deymeer F, Oflazer P, Hanagasi H, Gürvit H, Bilgiç B, Durmus H, Ertas M, Kotan D, Akalin MA, Güllüoglu H, Zarifoglu M, Aysal F, Dösoglu N, Bilguvar K, Günel M, Keskin Ö, Akgün T, Özçelik H, Landers JE, Brown RH, Basak AN. The distinct genetic pattern of ALS in Turkey and novel mutations. Neurobiol Aging. 2015 Apr; 36(4):1764.e9-18.
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Ward CL, Boggio KJ, Johnson BN, Boyd JB, Douthwright S, Shaffer SA, Landers JE, Glicksman MA, Bosco DA. A loss of FUS/TLS function leads to impaired cellular proliferation. Cell Death Dis. 2014 Dec 11; 5:e1572.
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Tibshirani M, Tradewell ML, Mattina KR, Minotti S, Yang W, Zhou H, Strong MJ, Hayward LJ, Durham HD. Cytoplasmic sequestration of FUS/TLS associated with ALS alters histone marks through loss of nuclear protein arginine methyltransferase 1. Hum Mol Genet. 2015 Feb 1; 24(3):773-86.
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Matus S, Bosco DA, Hetz C. Autophagy meets fused in sarcoma-positive stress granules. Neurobiol Aging. 2014 Dec; 35(12):2832-5.
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Sama RR, Ward CL, Bosco DA. Functions of FUS/TLS from DNA repair to stress response: implications for ALS. ASN Neuro. 2014 Jun 01; 6(4).
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Sama RR, Ward CL, Kaushansky LJ, Lemay N, Ishigaki S, Urano F, Bosco DA. FUS/TLS assembles into stress granules and is a prosurvival factor during hyperosmolar stress. J Cell Physiol. 2013 Nov; 228(11):2222-31.
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Sreedharan J, Brown RH. Amyotrophic lateral sclerosis: Problems and prospects. Ann Neurol. 2013 Sep; 74(3):309-16.
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Baron DM, Kaushansky LJ, Ward CL, Sama RR, Chian RJ, Boggio KJ, Quaresma AJ, Nickerson JA, Bosco DA. Amyotrophic lateral sclerosis-linked FUS/TLS alters stress granule assembly and dynamics. Mol Neurodegener. 2013 Aug 31; 8:30.
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Chesi A, Staahl BT, Jovicic A, Couthouis J, Fasolino M, Raphael AR, Yamazaki T, Elias L, Polak M, Kelly C, Williams KL, Fifita JA, Maragakis NJ, Nicholson GA, King OD, Reed R, Crabtree GR, Blair IP, Glass JD, Gitler AD. Exome sequencing to identify de novo mutations in sporadic ALS trios. Nat Neurosci. 2013 Jul; 16(7):851-5.
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Li YR, King OD, Shorter J, Gitler AD. Stress granules as crucibles of ALS pathogenesis. J Cell Biol. 2013 Apr 29; 201(3):361-72.
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