"Thioctic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Descriptor ID |
D008063
|
| MeSH Number(s) |
D02.241.803 D02.886.778.827 D08.211.906 D10.251.941
|
| Concept/Terms |
Thioctic Acid- Thioctic Acid
- alpha-Lipoic Acid
- Acid, alpha-Lipoic
- alpha Lipoic Acid
- Lipoic Acid
|
Below are MeSH descriptors whose meaning is more general than "Thioctic Acid".
Below are MeSH descriptors whose meaning is more specific than "Thioctic Acid".
This graph shows the total number of publications written about "Thioctic Acid" by people in this website by year, and whether "Thioctic Acid" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Thioctic Acid" by people in Profiles.
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Mishra MK, Wang J, Mirzaei R, Chan R, Melo H, Zhang P, Ling CC, Bruccoleri A, Tang L, Yong VW. A Distinct Hibiscus sabdariffa Extract Prevents Iron Neurotoxicity, a Driver of Multiple Sclerosis Pathology. Cells. 2022 01 27; 11(3).
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Tcheng JE, Gibson M, Krucoff MW, Patel MR, Ajit M, Hiremath J, Ponde C, Ramsaran E, Clark G, Lader AS, Beeuwkes R. SUPPORT-1 (Subjects Undergoing PCI and Perioperative Reperfusion Treatment): A Prospective, Randomized Trial of CMX-2043 in Patients Undergoing Elective Percutaneous Coronary Intervention. J Cardiovasc Pharmacol. 2020 08; 76(2):189-196.
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Juan YS, Levin RM, Chuang SM, Hydery T, Li S, Kogan B, Schuler C, Huang CH, Mannikarottu A. The beneficial effect of coenzyme Q10 and lipoic acid on obstructive bladder dysfunction in the rabbit. J Urol. 2008 Nov; 180(5):2234-40.
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Chompoosor A, Han G, Rotello VM. Charge dependence of ligand release and monolayer stability of gold nanoparticles by biogenic thiols. Bioconjug Chem. 2008 Jul; 19(7):1342-5.
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McMackin CJ, Widlansky ME, Hamburg NM, Huang AL, Weller S, Holbrook M, Gokce N, Hagen TM, Keaney JF, Vita JA. Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease. J Clin Hypertens (Greenwich). 2007 Apr; 9(4):249-55.
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Sigalov AB, Stern LJ. Dihydrolipoic acid as an effective cofactor for peptide methionine sulfoxide reductase in enzymatic repair of oxidative damage to both lipid-free and lipid-bound apolipoprotein a-I. Antioxid Redox Signal. 2002 Jun; 4(3):553-7.
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Haramaki N, Han D, Handelman GJ, Tritschler HJ, Packer L. Cytosolic and mitochondrial systems for NADH- and NADPH-dependent reduction of alpha-lipoic acid. Free Radic Biol Med. 1997; 22(3):535-42.
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Han D, Handelman GJ, Packer L. Analysis of reduced and oxidized lipoic acid in biological samples by high-performance liquid chromatography. Methods Enzymol. 1995; 251:315-25.