Mitogen-Activated Protein Kinase 8

"Mitogen-Activated Protein Kinase 8" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A c-jun amino-terminal kinase that is activated by environmental stress and pro-inflammatory cytokines. Several isoforms of the protein with molecular sizes of 43 and 48 KD exist due to multiple ALTERNATIVE SPLICING.

Descriptor ID	D048055
MeSH Number(s)	D08.811.913.696.620.682.700.567.374.500 D12.644.360.450.340.500 D12.776.476.450.340.500
Concept/Terms	Mitogen-Activated Protein Kinase 8 Mitogen-Activated Protein Kinase 8 Mitogen Activated Protein Kinase 8 c-jun Kinase-1 c jun Kinase 1 SAP Kinase-1 SAP Kinase 1 Stress-Activated Protein Kinase gamma Stress Activated Protein Kinase gamma c-jun N-Terminal Kinase 1 c jun N Terminal Kinase 1 MAPK8 Mitogen-Activated Protein Kinase MAPK8 Mitogen Activated Protein Kinase JNK1 Kinase SAPK1 Mitogen-Activated Protein Kinase SAPK1 Mitogen Activated Protein Kinase Stress-Activated Protein Kinase 1 Stress Activated Protein Kinase 1 Stress-Activated Protein Kinase JNK1 Stress Activated Protein Kinase JNK1

Below are MeSH descriptors whose meaning is more general than "Mitogen-Activated Protein Kinase 8".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Mitogen-Activated Protein Kinases [D08.811.913.696.620.682.700.567]
JNK Mitogen-Activated Protein Kinases [D08.811.913.696.620.682.700.567.374]
Mitogen-Activated Protein Kinase 8 [D08.811.913.696.620.682.700.567.374.500]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Mitogen-Activated Protein Kinases [D12.644.360.450]
JNK Mitogen-Activated Protein Kinases [D12.644.360.450.340]
Mitogen-Activated Protein Kinase 8 [D12.644.360.450.340.500]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Mitogen-Activated Protein Kinases [D12.776.476.450]
JNK Mitogen-Activated Protein Kinases [D12.776.476.450.340]
Mitogen-Activated Protein Kinase 8 [D12.776.476.450.340.500]

Below are MeSH descriptors whose meaning is related to "Mitogen-Activated Protein Kinase 8".

Below are MeSH descriptors whose meaning is more specific than "Mitogen-Activated Protein Kinase 8".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Mitogen-Activated Protein Kinase 8" by people in this website by year, and whether "Mitogen-Activated Protein Kinase 8" was a major or minor topic of these publications.

Bar chart showing 39 publications over 19 distinct years, with a maximum of 7 publications in 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	2	2
2002	0	7	7
2003	0	2	2
2004	0	1	1
2005	1	0	1
2006	2	0	2
2007	1	1	2
2008	2	0	2
2009	2	1	3
2010	5	0	5
2011	3	0	3
2012	1	0	1
2013	1	0	1
2014	1	0	1
2016	1	0	1
2017	1	0	1
2018	1	0	1
2020	1	1	2
2021	1	0	1

Below are the most recent publications written about "Mitogen-Activated Protein Kinase 8" by people in Profiles.

Smith AO, Jonassen JA, Preval KM, Davis RJ, Pazour GJ. c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease. PLoS Genet. 2021 12; 17(12):e1009711.

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Li Z, Oh H, Cung M, Marquez SJ, Sun J, Hammad H, Janssens S, Pouliot P, Lambrecht BN, Yang YS, Shim JH, Greenblatt MB. TAOK3 is a MAP3K contributing to osteoblast differentiation and skeletal mineralization. Biochem Biophys Res Commun. 2020 10 22; 531(4):497-502.

View in: PubMed
van der Velden JL, Alcorn JF, Chapman DG, Lundblad LKA, Irvin CG, Davis RJ, Butnor K, Janssen-Heininger YMW. Airway epithelial specific deletion of Jun-N-terminal kinase 1 attenuates pulmonary fibrosis in two independent mouse models. PLoS One. 2020; 15(1):e0226904.

View in: PubMed
Barutcu SA, Girnius N, Vernia S, Davis RJ. Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy. Autophagy. 2018; 14(9):1586-1595.

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Xu R, Zhang C, Shin DY, Kim JM, Lalani S, Li N, Yang YS, Liu Y, Eiseman M, Davis RJ, Shim JH, Greenblatt MB. c-Jun N-Terminal Kinases (JNKs) Are Critical Mediators of Osteoblast Activity In Vivo. J Bone Miner Res. 2017 Sep; 32(9):1811-1815.

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Lu H, Wang T, Li J, Fedele C, Liu Q, Zhang J, Jiang Z, Jain D, Iozzo RV, Violette SM, Weinreb PH, Davis RJ, Gioeli D, FitzGerald TJ, Altieri DC, Languino LR. ?v?6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor. Cancer Res. 2016 09 01; 76(17):5163-74.

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Schaefer FM, Peng J, Hu W, Drvarov O, Nevzorova YA, Zhao G, Masaoudi MA, Davis RJ, Trautwein C, Cubero FJ. Bone marrow-derived c-jun N-terminal kinase-1 (JNK1) mediates liver regeneration. Biochim Biophys Acta. 2015 Jan; 1852(1):137-45.

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Goel HL, Sayeed A, Breen M, Zarif MJ, Garlick DS, Leav I, Davis RJ, Fitzgerald TJ, Morrione A, Hsieh CC, Liu Q, Dicker AP, Altieri DC, Languino LR. ?1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase 1. J Cell Physiol. 2013 Jul; 228(7):1601-9.

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Han MS, Jung DY, Morel C, Lakhani SA, Kim JK, Flavell RA, Davis RJ. JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science. 2013 Jan 11; 339(6116):218-22.

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Cellurale C, Girnius N, Jiang F, Cavanagh-Kyros J, Lu S, Garlick DS, Mercurio AM, Davis RJ. Role of JNK in mammary gland development and breast cancer. Cancer Res. 2012 Jan 15; 72(2):472-81.

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