Diabetes Mellitus, Type 1

"Diabetes Mellitus, Type 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.

Descriptor ID	D003922
MeSH Number(s)	C18.452.394.750.124 C19.246.267 C20.111.327
Concept/Terms	Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 1 Diabetes Mellitus, Brittle Brittle Diabetes Mellitus Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus, Insulin Dependent Insulin-Dependent Diabetes Mellitus Diabetes Mellitus, Juvenile-Onset Diabetes Mellitus, Juvenile Onset Juvenile-Onset Diabetes Mellitus Diabetes Mellitus, Ketosis-Prone Diabetes Mellitus, Ketosis Prone Ketosis-Prone Diabetes Mellitus Juvenile-Onset Diabetes Diabetes, Juvenile-Onset Juvenile Onset Diabetes Diabetes Mellitus, Type I Diabetes Mellitus, Sudden-Onset Diabetes Mellitus, Sudden Onset Mellitus, Sudden-Onset Diabetes Sudden-Onset Diabetes Mellitus Type 1 Diabetes Mellitus Diabetes Mellitus, Insulin-Dependent, 1 Insulin-Dependent Diabetes Mellitus 1 Insulin Dependent Diabetes Mellitus 1 Type 1 Diabetes Diabetes, Type 1 IDDM Diabetes, Autoimmune Diabetes, Autoimmune Autoimmune Diabetes

Below are MeSH descriptors whose meaning is more general than "Diabetes Mellitus, Type 1".

Diseases [C]
Nutritional and Metabolic Diseases [C18]
Metabolic Diseases [C18.452]
Glucose Metabolism Disorders [C18.452.394]
Diabetes Mellitus [C18.452.394.750]
Diabetes Mellitus, Type 1 [C18.452.394.750.124]
Endocrine System Diseases [C19]
Diabetes Mellitus [C19.246]
Diabetes Mellitus, Type 1 [C19.246.267]
Immune System Diseases [C20]
Autoimmune Diseases [C20.111]
Diabetes Mellitus, Type 1 [C20.111.327]

Below are MeSH descriptors whose meaning is related to "Diabetes Mellitus, Type 1".

Below are MeSH descriptors whose meaning is more specific than "Diabetes Mellitus, Type 1".

Diabetes Mellitus, Type 1
Wolfram Syndrome

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Diabetes Mellitus, Type 1" by people in this website by year, and whether "Diabetes Mellitus, Type 1" was a major or minor topic of these publications.

Bar chart showing 389 publications over 31 distinct years, with a maximum of 26 publications in 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	4	1	5
1996	9	0	9
1997	4	1	5
1998	4	0	4
1999	7	2	9
2000	2	0	2
2001	10	0	10
2002	14	1	15
2003	21	0	21
2004	20	1	21
2005	14	1	15
2006	16	1	17
2007	15	1	16
2008	8	1	9
2009	24	2	26
2010	18	2	20
2011	15	2	17
2012	9	3	12
2013	10	0	10
2014	12	1	13
2015	11	2	13
2016	19	3	22
2017	13	3	16
2018	12	1	13
2019	11	1	12
2020	15	0	15
2021	10	1	11
2022	10	0	10
2023	12	0	12
2024	5	2	7
2025	2	0	2

Below are the most recent publications written about "Diabetes Mellitus, Type 1" by people in Profiles.

Carr? A, Samassa F, Zhou Z, Perez-Hernandez J, Lekka C, Manganaro A, Oshima M, Liao H, Parker R, Nicastri A, Brandao B, Colli ML, Eizirik DL, Aluri J, Patel D, G?ransson M, Burgos Morales O, Anderson A, Landry L, Kobaisi F, Scharfmann R, Marselli L, Marchetti P, You S, Nakayama M, Hadrup SR, Kent SC, Richardson SJ, Ternette N, Mallone R. Interferon-a promotes HLA-B-restricted presentation of conventional and alternative antigens in human pancreatic ?-cells. Nat Commun. 2025 Jan 17; 16(1):765.

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Arowosegbe A, Guo Z, Vanderleeden E, Derr AG, Wang JP. Janus kinase inhibition prevents autoimmune diabetes in LEW.1WR1 rats. J Autoimmun. 2025 Feb; 151:103358.

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Sundstrom J, Vanderleeden E, Barton NJ, Redick SD, Dawes P, Murray LF, Olson MN, Tran K, Chigas SM, Orszulak AR, Church GM, Readhead B, Oh HS, Harlan DM, Knipe DM, Wang JP, Chan Y, Lim ET. Herpes Simplex Virus 1 Infection of Human Brain Organoids and Pancreatic Stem Cell-Islets Drives Organoid-Specific Transcripts Associated with Alzheimer's Disease and Autoimmune Diseases. Cells. 2024 Nov 29; 13(23).

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Price J, Hawkins J, Amante DJ, James R, Haire-Joshu D. Implementation Science and Pediatric Diabetes: A Scoping Review of the State of the Literature and Recommendations for Future Research. Curr Diab Rep. 2024 Oct 29; 25(1):2.

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Serreze DV, Dwyer JR, Racine JJ. Advancing Animal Models of Human Type 1 Diabetes. Cold Spring Harb Perspect Med. 2024 Oct 01; 14(10).

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Perez D, Sullivan-Bolyai S, Bova C, Fain J. Burnout Among Young Adults With Type 1 Diabetes. Sci Diabetes Self Manag Care. 2024 Jun; 50(3):211-221.

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Amdare NP, Shultz LD, Greiner DL, DiLorenzo TP. Human insulin as both antigen and protector in type 1 diabetes. Eur J Immunol. 2024 Sep; 54(9):e2350949.

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Callebaut A, Guyer P, Derua R, Buitinga M, Manganaro A, Yi X, Sodr? FMC, Vig S, Suleiman M, Marchetti P, Eizirik DL, Kent SC, Mathieu C, James EA, Overbergh L. CD4+ T Cells From Individuals With Type 1 Diabetes Respond to a Novel Class of Deamidated Peptides Formed in Pancreatic Islets. Diabetes. 2024 May 01; 73(5):728-742.

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Vecchio F, Carr? A, Korenkov D, Zhou Z, Apaolaza P, Tuomela S, Burgos-Morales O, Snowhite I, Perez-Hernandez J, Brandao B, Afonso G, Halliez C, Kaddis J, Kent SC, Nakayama M, Richardson SJ, Vinh J, Verdier Y, Laiho J, Scharfmann R, Solimena M, Marinicova Z, Bismuth E, Lucidarme N, Sanchez J, Bustamante C, Gomez P, Buus S, You S, Pugliese A, Hyoty H, Rodriguez-Calvo T, Flodstrom-Tullberg M, Mallone R. Coxsackievirus infection induces direct pancreatic ? cell killing but poor antiviral CD8+ T cell responses. Sci Adv. 2024 Mar 08; 10(10):eadl1122.

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Nwosu BU, Parajuli S, Sharma RB, Lee AF. Effect of Ergocalciferol on ?-Cell Function in New-Onset Type 1 Diabetes: A Secondary Analysis of a Randomized Clinical Trial. JAMA Netw Open. 2024 03 04; 7(3):e241155.

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