Codon, Nonsense

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"Codon, Nonsense" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An amino acid-specifying codon that has been converted to a stop codon (CODON, TERMINATOR) by mutation. Its occurance is abnormal causing premature termination of protein translation and results in production of truncated and non-functional proteins. A nonsense mutation is one that converts an amino acid-specific codon to a stop codon.

Descriptor ID	D018389
MeSH Number(s)	D13.444.735.544.355.250.235 G05.360.335.355.250.235 G05.365.590.195
Concept/Terms	Codon, Nonsense Codon, Nonsense Premature Termination Codon Codon, Premature Termination Codons, Premature Termination Premature Termination Codons Termination Codon, Premature Termination Codons, Premature Premature Stop Codon Codon, Premature Stop Codons, Premature Stop Premature Stop Codons Stop Codon, Premature Stop Codons, Premature Nonsense Codon Codons, Nonsense Nonsense Codons Codon, Termination, Premature Mutation, Nonsense Mutation, Nonsense Mutations, Nonsense Nonsense Mutations Nonsense Mutation Ochre Nonsense Codon Ochre Nonsense Codon Codon, Ochre Nonsense Codons, Ochre Nonsense Nonsense Codon, Ochre Nonsense Codons, Ochre Ochre Nonsense Codons Ochre Nonsense Mutation Ochre Nonsense Mutation Mutation, Ochre Nonsense Mutations, Ochre Nonsense Nonsense Mutation, Ochre Nonsense Mutations, Ochre Ochre Nonsense Mutations Amber Nonsense Mutation Amber Nonsense Mutation Amber Nonsense Mutations Mutation, Amber Nonsense Mutations, Amber Nonsense Nonsense Mutation, Amber Nonsense Mutations, Amber Opal Nonsense Mutation Opal Nonsense Mutation Mutation, Opal Nonsense Mutations, Opal Nonsense Nonsense Mutation, Opal Nonsense Mutations, Opal Opal Nonsense Mutations Amber Nonsense Codon Amber Nonsense Codon Amber Nonsense Codons Codon, Amber Nonsense Codons, Amber Nonsense Nonsense Codons, Amber Nonsense Codon, Amber Codon, Unassigned Codon, Unassigned Codons, Unassigned Unassigned Codons Unassigned Codon Opal Nonsense Codon Opal Nonsense Codon Codon, Opal Nonsense Codons, Opal Nonsense Nonsense Codon, Opal Nonsense Codons, Opal Opal Nonsense Codons

Below are MeSH descriptors whose meaning is more general than "Codon, Nonsense".

Chemicals and Drugs [D]
Nucleic Acids, Nucleotides, and Nucleosides [D13]
Nucleic Acids [D13.444]
RNA [D13.444.735]
RNA, Messenger [D13.444.735.544]
Codon [D13.444.735.544.355]
Codon, Terminator [D13.444.735.544.355.250]
Codon, Nonsense [D13.444.735.544.355.250.235]
Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Genetic Code [G05.360.335]
Codon [G05.360.335.355]
Codon, Terminator [G05.360.335.355.250]
Codon, Nonsense [G05.360.335.355.250.235]
Genetic Variation [G05.365]
Mutation [G05.365.590]
Codon, Nonsense [G05.365.590.195]

Below are MeSH descriptors whose meaning is more specific than "Codon, Nonsense".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Codon, Nonsense" by people in this website by year, and whether "Codon, Nonsense" was a major or minor topic of these publications.

Bar chart showing 7 publications over 6 distinct years, with a maximum of 2 publications in 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2006	0	1	1
2010	1	0	1
2011	0	1	1
2012	1	0	1
2022	1	1	2
2024	0	1	1

Below are the most recent publications written about "Codon, Nonsense" by people in Profiles.

Wang J, Gao G, Wang D. Developing AAV-delivered nonsense suppressor tRNAs for neurological disorders. Neurotherapeutics. 2024 Jul; 21(4):e00391.

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Wang D, Xue X, Gunn G, Du M, Siddiqui A, Weetall M, Keeling KM. Ataluren suppresses a premature termination codon in an MPS I-H mouse. J Mol Med (Berl). 2022 08; 100(8):1223-1235.

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Wang J, Zhang Y, Mendonca CA, Yukselen O, Muneeruddin K, Ren L, Liang J, Zhou C, Xie J, Li J, Jiang Z, Kucukural A, Shaffer SA, Gao G, Wang D. AAV-delivered suppressor tRNA overcomes a nonsense mutation in mice. Nature. 2022 04; 604(7905):343-348.

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Ganesan R, Leszyk J, Jacobson A. Selective profiling of ribosomes associated with yeast Upf proteins. Methods. 2019 02 15; 155:58-67.

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Platt CD, Fried AJ, Hoyos-Bachiloglu R, Usmani GN, Schmidt B, Whangbo J, Chiarle R, Chou J, Geha RS. Combined immunodeficiency with EBV positive B cell lymphoma and epidermodysplasia verruciformis due to a novel homozygous mutation in RASGRP1. Clin Immunol. 2017 10; 183:142-144.

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Friesen WJ, Trotta CR, Tomizawa Y, Zhuo J, Johnson B, Sierra J, Roy B, Weetall M, Hedrick J, Sheedy J, Takasugi J, Moon YC, Babu S, Baiazitov R, Leszyk JD, Davis TW, Colacino JM, Peltz SW, Welch EM. The nucleoside analog clitocine is a potent and efficacious readthrough agent. RNA. 2017 04; 23(4):567-577.

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Roy B, Friesen WJ, Tomizawa Y, Leszyk JD, Zhuo J, Johnson B, Dakka J, Trotta CR, Xue X, Mutyam V, Keeling KM, Mobley JA, Rowe SM, Bedwell DM, Welch EM, Jacobson A. Ataluren stimulates ribosomal selection of near-cognate tRNAs to promote nonsense suppression. Proc Natl Acad Sci U S A. 2016 11 01; 113(44):12508-12513.

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Wang T, Xu C, Zhou X, Li C, Zhang H, Lian BQ, Lee JJ, Shen J, Liu Y, Lian CG. Homozygous ALOXE3 Nonsense Variant Identified in a Patient with Non-Bullous Congenital Ichthyosiform Erythroderma Complicated by Superimposed Bullous Majocchi's Granuloma: The Consequences of Skin Barrier Dysfunction. Int J Mol Sci. 2015 Sep 09; 16(9):21791-801.

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Murdoch JD, Gupta AR, Sanders SJ, Walker MF, Keaney J, Fernandez TV, Murtha MT, Anyanwu S, Ober GT, Raubeson MJ, DiLullo NM, Villa N, Waqar Z, Sullivan C, Gonzalez L, Willsey AJ, Choe SY, Neale BM, Daly MJ, State MW. No evidence for association of autism with rare heterozygous point mutations in Contactin-Associated Protein-Like 2 (CNTNAP2), or in Other Contactin-Associated Proteins or Contactins. PLoS Genet. 2015 Jan; 11(1):e1004852.

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Keeling KM, Wang D, Conard SE, Bedwell DM. Suppression of premature termination codons as a therapeutic approach. Crit Rev Biochem Mol Biol. 2012 Sep; 47(5):444-63.

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